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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Sperm counts and sperm sex ratio in male infertility patients显示文摘在最近的年里,调查者在许多工业化国家向男出生的一个衰退比例注意了一个趋势。当人们忍受决定性的染色体时,它与授精或流产相关的女搭挡的角色可以也改变性比率。我们试图由直接检验他的精子的性染色体决定一个人的第二等的性比率(F1 产生) 。我们为在 situ 杂交(鱼) 经历了精液荧光的所有人检验了我们的男不孕诊所数据库。人口统计的病人和精液参数被记录。摆平 Chi 的分析被用来比较性比率(Y 染色体 / 总数染色体) 。Multivariable 逻辑回归被用来预言在财务以后拥有一个忍受 Y 精子为的机会人口统计并且精液参数。185 个人的一个总数经历了精子鱼。为全部队, Y 忍受染色体的精子的比例是 51.5 %。有不到 500 万个能动精子的人有 Y 忍受染色体的精子的一个显著地更低的比例(50.8 %) 与有更高的精子计数的人相比(51.6 %P=0.02 ) 。在 multivariable 调整以后,更高的精子集中,全部的能动精子计数和精液体积显著地增加了有 Y 的机会忍受染色体的精子(P< 0.01 ) 。作为一个人的精子生产衰落,那么做 Y 忍受染色体的精子的比例。因此,一个人的繁殖潜力可以预言他的能力到陛下男性后代。 | Michael L Eisenberg Lata Murthy Kathleen Hwang Dolores J Lamb Larry I Lipshultz | 2012 | Asian Journal of Andrology2012，14，5： | 3 |
| 3 | Effects of light emitting diodes on the in vitro induction and growth of bulhlets of Liliurn oriental hybrid Pesaro 显示文摘 | Lian M L Murthy H N Pack K Y | 2002 | Scientia Horticulturae2002，94，3： | 1 |
| 4 | Homeodomain protein HLX is expressed primarily in cytotrophoblast cell types in the early pregnancy human placenta 显示文摘 | Rajaraman G Murthi P Quinn L | 2008 | Reprod Fertil Dev2008，20，： | 1 |
| 5 | On using peak amplitude and rise time for AE source显示文摘 | Majeed M A Murthy C R L | 2002 | Sadhana2002，27，3： | 1 |
| 6 | Crystalline constitutents of Fluggea microcarpa Blume显示文摘 | JAIRAI M A | 1988 | J Ind Chem Soc1988，65，： | 1 |
| 7 | Interrelationships Between Zine and Copper Nutrition in the Rat显示文摘 | Murthy L Prasad K | 1974 | Nutr1974，104，： | 1 |
| 8 | Diagnosis,prevention,and management of delirium:summary of NICE guigance显示文摘 | Young J Murthy L Westby M | | 0，，： | 1 |
| 9 | Comparison of inflammation, organ damage,and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide 显示文摘 | Liaudet L Murthy KG Mabley JG | 2002 | Infect Immun2002，70，1： | 1 |
| 10 | The efficacy of mag- netic resonance imaging to predict occult invasive cancer in the breast and axilla among patients diagnosed with ductal carcinoma in situ on core biopsy显示文摘 | Sparber L S Murthy V Sanders L M | 2014 | J Surg Res2014，186，2： | 1 |
| 11 | Probabilistic analysis of a SiC/SiC ceramic matrix compsoite turbine vane显示文摘 | Murthy P L N Nemeth N N Brewer D V Mital S | 2008 | Composites Part B: Engi- neering2008，39，4： | 1 |
| 12 | Semi-symmetric Ideals in Near Rings显示文摘 | Reddy Y F Murthy C V L N | 1985 | Indian J Pure Applied Math1985，16，： | 1 |
| 13 | Concomitant eisplatin/5-FU infusion and radiotherapy in advanced head and neck cancer: 8-year analysis of results 显示文摘 | Taylor S G 4th Murthy A K Griem K L | 1997 | Head Neck1997，19，8： | 1 |
| 14 | Photocatalytic ac- tivity of TiO2 doped with Zn^2+ and V^5+ transition metal ions: Influence of crystallite size and dopant electronic configuration on photocatalytic activity 显示文摘 | Devil L G Murthy B N Kumar S G | 2010 | Materials Science and Engineering B2010，166，1： | 1 |
| 15 | Biosorption of lead from aqueous solution by seed powder of Strychnos potatorum L 显示文摘 | Jayaram K Murthy I Y L N Lalhruaitluanga H | 2009 | Colloids Surfaces B : Biointerfaces2009，71，2： | 1 |
| 16 | Effect of light emitting diodes (LEDs) on the in vitro induction and growth of bulblets of Lilium oriental hybrid 'Pesaro' 显示文摘 | Lian M L Murthy H N Paek K Y | 2002 | Scientia Horticulturae2002，94，3： | 1 |
| 17 | An Efficient Routing Protocol for Wireless Networks显示文摘 | Murthy S Garcia L A | 1996 | ACM Mobile Networks and Applications1996，1，2： | 1 |
| 18 | Identification of redox/repair protein Ref-1 as a potent activator of p53显示文摘 | Jayaraman L Murthy K G Zhu C | 1997 | Genes Dev1997，11，5： | 1 |
| 19 | Orbital cysticercosis-an ultrasound diagnosis显示文摘 | Murthy H Kumar A Verma L | 1990 | Acta Ophthalmol(Copenh)1990，68，： | 1 |
| 20 | The role of rapidendoscopy for high-risk patients with acute nonvariceal uppergastrointestinal bleeding 显示文摘 | Targownik LE Murthy S Keyvani L | 2007 | Can J Gastroenterol2007，21，7： | 1 |
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