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| 1 | Modulation of tau phosphorylation by environmental copper显示文摘Background:The transition metal copper enhances amyloidβaggregation and neurotoxicity,and in models of concomitant amyloid and tau pathology,copper also promotes tau aggregation.Since it is not clear if the effects of environmental copper upon tau pathology are dependent on the presence of pathological amyloidβ,we tested the effects of copper overload and complexing in disease models which lack pathological amyloidβ.Methods:We used cell culture and transgenic murine models to test the effects of environmental copper on tau phosphorylation.We used oral zinc acetate as a copper lowering agent in mice and examined changes in blood and brain metals through inductively coupled plasma mass spectroscopy.Behavioral effects of copper lowering were assessed with Morris water maze and novel object recognition tasks.Changes in tau phosphorylation were examined by phosphorylation specific antibodies on Western blots.Results:In human neuroblastoma cells,excess copper promoted tau phosphorylation and a copper complexing agent,tetrathiomolybdate,attenuated tau phosphorylation.In a transgenic mouse model expressing wild type human tau,copper-lowering by oral zinc suppressed plasma and brain levels of copper,and resulted in a marked attenuation of tau phosphorylation.No significant changes in behavior were observed with copper lowering,but a trend to improved recognition of the novel object was observed in zinc acetate treated mice.Conclusions:We propose that reduction of brain copper by blocking uptake of copper from the diet may be a viable strategy for modulating tau pathology in Alzheimer’s disease.The potential benefits of this approach are tempered by the absence of a behavioral benefit and by the health risks of excessive lowering of copper. | Kellen Voss Christopher Harris Martina Ralle Megan Duffy Charles Murchison Joseph F Quinn | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 2 | Paradoxical embolus straddling patent foramen ovale demonstrated by computed tomographic pulmonary angiography显示文摘An elderly gentleman presented to the emergency department with a recent history of dyspnoea, collapse and transient neurological symptoms. He was noted to be hypoxic with a significantly elevated D Dimer. A computer tomography pulmonary angiogram demonstrated a large embolus with a further filling defects within the left and the right atria, abutting the interatrial septum. Suspicion of a paradoxical pulmonary embolus was raised and the patient subsequently underwent echocardiography which confirmed a patent foramen ovale(PFO). He was commenced on warfarin therapy. In patients with elevated right heart pressure, a PFO can be unmasked and give rise to cerebral emboli. Clinical suspicion should be raised in patients with pulmonary emboli or deep venous thrombosis if there is a concomitant history of focal neurological symptoms. | Laura Cormack John T Murchison | 2013 | World Journal of Clinical Cases2013，1，3： | 2 |
| 3 | Dicer is essential for mouse development 显示文摘 | Benrstein E Kim SY Carmell MA Murchison EP Alcorn H Li MZ | 2003 | Nat Genet2003，35，3： | 1 |
| 4 | Incisal edge reattachment:indications for use and clinical technique显示文摘 | Murchison D F Burke F J Worthington R B | 1999 | Br Dent J1999，186，12： | 1 |
| 5 | Memory, mood, and vitamin D in persons with Parkinson's disease 显示文摘 | Peterson AL Murchison C Zabetian C | 2013 | J Parkinsons Dis2013，3，4： | 1 |
| 6 | A Suggestion for a Simple Cross - Country Empirical Proxy for Trend Unemployment 显示文摘 | Stephen C Murchison Pierre L Siklos | 1999 | Applied Economics Letters1999，，6： | 1 |
| 7 | Carbamide peroxide bleaching:effects on enamel surface hardness and bonding显示文摘 | Murchison DF Charlton DG Moore BK | 1992 | Oper Dent1992，17，： | 1 |
| 8 | Post reten- tion: the effect of sequence of post--space preparation, ce mentation time, and different sealers显示文摘 | Boone KJ Murchison DF Schindler WG | 2001 | J Endod2001，27，12： | 1 |
| 9 | CT-guided lung biopsy:factors influencing diagnostic yield and complication rate 显示文摘 | Anderson JM Murchison J Patel D | 2003 | Clin Radiol2003，58，： | 1 |
| 10 | CT-guided lung biopsy: factors influencing diagnostic yield and complication rate显示文摘 | Anderson JM Murchison J Patel D | 2003 | Clinical Radiology2003，58，3： | 1 |
| 11 | Transformation of Streptococcus mutans with chromosomal and shuttle plasmid (pYA629) DNAs显示文摘 | Murchison HH Barrett JF Cardineau GA | 1986 | Infect Immun1986，54，： | 1 |
| 12 | Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons显示文摘 | Murchison ND Price BA Conner DA | 2007 | Development2007，134，： | 1 |
| 13 | CT-Guided Lung Biopsy Factors Influencing Diagnostic Yield and Complication Rate 显示文摘 | Anderson JM Murchison J Patel D | 2003 | Clin Radi- o12003，58，3： | 1 |
| 14 | Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoringtendons显示文摘 | Murchison ND Price BA Conner DA | 2007 | Development2007，134，14： | 1 |
| 15 | Enlargement of the temporal clear corneal cataract incision to treat pre existing astigmatism 显示文摘 | Rao SN Konowal A Murchison AE | 2002 | Refract Surg2002，18，： | 1 |
| 16 | Mitochondria buffer non-toxic calcium loads and release calcium through the mitochondrial permeability transition pore and sodium/ calcium exchanger in rat basal forebrain neurons显示文摘 | Murchison D Griffith WH | 2000 | Brain Res2000，854，12： | 1 |
| 17 | Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure 显示文摘 | Chen JF Murchison EP Tang R | 2008 | Proc Natl Acad Sci U S A2008，105，6： | 1 |
| 18 | An evaluation of three surgical approaches for coexisting cataract and glaucoma显示文摘 | Murchison J F Shields MB | 1989 | Ophthalmic Surg1989，20，3： | 1 |
| 19 | CT-guided lung biopsy:factors influencing diagnostia yield and complication rate显示文摘 | Anderson JM Murchison J Patel D | 2003 | Clin Radiol2003，8，15： | 1 |
| 20 | Influence of exinite macerals on the reflectance of carboniferous sediments of the Middland Valley of Sootland 显示文摘 | Raymond A C Murchison D G | 1991 | Fule1991，70，2： | 1 |
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