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| 1 | Establishing proof of concept:Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus显示文摘Osteochondral lesions of the talus are common injuries in the athletic patient. They present a challenging clinical problem as cartilage has a poor potential for healing. Current surgical treatments consist of reparative(microfracture) or replacement(autologous osteochondral graft) strategies and demonstrate good clinical outcomes at the short and medium term follow-up. Radiological findings and second-look arthroscopy however, indicate possible poor cartilage repair with evidence of fibrous infill and fissuring of the regenerative tissue following microfracture. Longer-term follow-up echoes these findings as it demonstrates a decline in clinical outcome. The nature of the cartilage repair that occurs for an osteochondral graft to become integrated with the native surround tissue is also of concern. Studies have shown evidence of poor cartilage integration,with chondrocyte death at the periphery of the graft, possibly causing cyst formation due to synovial fluid ingress. Biological adjuncts, in the form of platelet-rich plasma(PRP) and bone marrow aspirate concentrate(BMAC), have been investigated with regard to their potential in improving cartilage repair in both in vitro and in vitro settings. The in vitro literature indicates that these biological adjuncts may increase chondrocyte proliferation as well as synthetic capability, while limiting the catabolic effects of an inflammatory joint environment. These findings have been extrapolated to in vitro animal models, with results showing that both PRP and BMAC improve cartilage repair. The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus. | Niall A Smyth Christopher D Murawski Amgad M Haleem Charles P Hannon Ian Savage-Elliott John G Kennedy | 2012 | World Journal of Orthopedics2012，3，7： | 8 |
| 2 | About the undecidability of program equivalence in finitary languages with state显示文摘 | Murawski A S | 2004 | ACM Transactions on Computational Losic2004，，： | 1 |
| 3 | Neonatal alcohol ex- posure and the hippocampus in developing male rats: effects on be- haviorally induced CA1 c-Fos expression, CA1 pyramidal cell num- ber, and contextual fear conditioning 显示文摘 | Murawski N J Klintsova AY and Stanton ME | 2012 | Neurescience2012，206，： | 1 |
| 4 | Evalu- ation of superoxide dismutase activity and its impact on semen quality parameters of infertile men显示文摘 | Murawski M Saczko J Mareinkowska A | 2007 | FoHa Histochem Cytobiol2007，45，1： | 1 |
| 5 | Shaft line alignment analysis taking ship construction flexibility and deformations into con- sideration 显示文摘 | MURAWSKI L | 2005 | Marine Structures2005，18，1： | 1 |
| 6 | Rituximab in high-grade lymphoma显示文摘 | Zwick C Murawski N Pfreundschuh M German High-Grade Non-Hodgkin Lymphoma Study Group | | 0，，02： | 1 |
| 7 | Evaluation of superoxide dismutase activity and its impact on semen quality parameters of infertile men显示文摘 | Murawski M Saczko J Marcinkowska A | 2007 | Folia Histochemica et cytobiologica2007，45，1： | 1 |
| 8 | Veslcoureteric reflux and renal malformations: a development problem显示文摘 | Murawski IJ Gupta IR | 2006 | Clin Genct2006，69，12： | 1 |
| 9 | Investigations of Marine Safety Improvements by Structural Health Monitoring Systems 显示文摘 | Murawski L Opoka S Majewska K | 2012 | International Journal on Marine Navigation and Safety of Sea Transportation2012，6，2： | 1 |
| 10 | Immunocytochemical localisation of PTHrP( parathormone- related peptide) in myoepithelial cells of human sweat and parotid glands显示文摘 | Zabel M Murawski M Surdyk-Zasada J | 1999 | Folia Histochem Cytobiol1999，37，3： | 1 |
| 11 | One, two or three port appendectomy-a rational approach显示文摘 | Go~rebiewski A Losin M Murawski M | 2013 | Wideochir Inne Tech Malo Inwazyjne2013，8，3： | 1 |
| 12 | Shaft line alignment analysis taking ship construction flexibility and deformations into consideration 显示文摘 | MURAWSKI L | 2005 | Marine Structures2005，18，： | 1 |
| 13 | Percutaneous Internal Fixation of Proximal Fifth Metatarsal Jones Fractures (Zones Ⅱ and Ⅲ) With Charlotte Carolina Screw and Bone Marrow Aspirate Concentrate An Outcome Study in Athletes显示文摘 | Murawski C D Kennedy J G | 2011 | The American journal of sports medicine2011，39，6： | 1 |
| 14 | Ten Myths Concerning Ecosystem Approaches to Marine Resource Management 显示文摘 | Murawski S A | 2007 | Marine Policy2007，31，6： | 1 |
| 15 | Primary malignant fibrous histiocytoma of the lung显示文摘 | Rzyman W Jaskiewicz K Murawski M | 2007 | Thorac Cardiovasc Surg2007，55，3： | 1 |
| 16 | Characteristics and Capacity of VDL Mode 2, 3, and 4 Subnetworks 显示文摘 | Steven C Bretmersky Robert W Murawski Vijay K Konangi | 2005 | Journal of Aerospace Computing Information and Communication (S1940-3151)2005，2，11： | 1 |
| 17 | Laparoscopic surgical technique to facilitate management of high anorectal malformations-report of seven cases显示文摘 | Gotebiewski A Murawski M Losin M | 2011 | Wideochir Inne Tech Malo Inwazyjne2011，6，3： | 1 |
| 18 | The breeding structure of tropical tree populations显示文摘 | Hamrick J L Murawski D A | 1990 | Plant Species Biol1990，5，1： | 1 |
| 19 | Scavenging of reactiveoxygen species and inhibition of arachidonic acid metabolism bysilibum in human cells显示文摘 | Dehmlow C Murawski N de Groot H | 1996 | J Life Sci1996，18，： | 1 |
| 20 | Operative treatment of osteochondral lesions of the talus 显示文摘 | Murawski CD Kennedy JG | 2013 | J Bone Joint Surg Am2013，95，11： | 1 |
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