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| 1 | 从附睾到卵子:CRISP蛋白在哺乳动物受精过程中的作用显示文摘哺乳动物的受精过程涉及精卵结合的很多步骤,是一个非常复杂的过程,其分了机制亟待阐明。此篇综述主要论述了CRISP(富含半胱氨酸的分泌蛋白)作为模型分子在哺乳动物受精过程中的价值。大量的体外实验和基因敲出模型研究显示,附睾内的CRISP1以两种不同的亲和力结合于精子表面,参与精子获能、精子-透明带结合、精卵融合的调控。这些研究成果可以延伸至人类。我们住研究中发现,人类具有与啮齿类同源的CRISP(hCRISP1),同样参与受精过样。CRISP家族的其他成员(睾丸内CRISP2、附挈内CRISP3—4、射精时的CRISP3)也参与了精卵结合的过程,提示同源分子间的相互协同有助于受精的成功。另外,我们的研究显示,CRISP蛋白伴随精子穿越男性及女性生殖管道的全过程。我们推测CRISP不仅参与了受精过程,而且可能成为不育和避孕研究的新靶点。 | Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-Elias Debora J Cohen Patricia S Cuasnicu | 2015 | Asian Journal of Andrology2015，17，5： | 5 |
| 2 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 3 | A trick shot to the corner pocket显示文摘 | Tran D Q Munoz L Russo G | 2008 | Reg Anesth Pain Med2008，33，5： | 1 |
| 4 | An improved method for preparing very high molecular weight polyimides 显示文摘 | Munoz D M Calle M de La Campa J G | 2009 | Macromoleeules(S0024-9297)2009，42，15： | 1 |
| 5 | The neuropathology and biochemistry of frontotemperal dementia显示文摘 | Munoz D G Dickson D W Bergeron C | 2003 | Ann Neurol2003，54，5： | 1 |
| 6 | Grapefruit juice-felodipine interaction: effects of naringin and 6', 7'-dihydroxydergamotlin in humans显示文摘 | BAILEY D G KREOFT K H MUNOZ C et nl | 1998 | Clin Phnrmacol Ther1998，64，3： | 1 |
| 7 | Formation of Zn-Ni alloys in the phosphating of Zn layers显示文摘 | Zimmermann D Munoz A G Schultze J W | 2005 | Surface and Coatings Technology2005，197，23： | 1 |
| 8 | Accumulationof phosphorylated neurofilaments in anterior horn motoneuronsof amyotrophic lateral sclerosis patients 显示文摘 | MUNOZ D G GREENE C PERL D P | 1988 | Journal of neu-ropathology and experimental neurology1988，47，1： | 1 |
| 9 | Induced anisotropy,megnetic do main structure and magnetoimpedance effect in CoFeB amorphous thin films显示文摘 | Garcia D Munoz J L Kurlyandskaya G | 1999 | J Magn Magn Mater1999，191，： | 1 |
| 10 | The Lgr5 intestinal stem cell signature:robust expression of proposed quiescent ' + 4 ' cell markers 显示文摘 | MUNOZ J STANGE D E SCHEPERS A G | 2012 | EMBO J2012，31，14： | 1 |
| 11 | Causes of Alzheimer' s disease 显示文摘 | Munoz D G Feldman H | 2000 | CMAJ2000，162，1： | 1 |
| 12 | Two novel BRM insertion promoter sequence variants are associated with loss of BRM expression and lung cancer risk显示文摘 | LIU G GRAMLING S MUNOZ D | 2011 | Oncogene2011，30，29： | 1 |
| 13 | Formation of Zn-Ni alloys in the phosphating of Zn layers 显示文摘 | Zimmermann D Munoz A G Schultze J W | 2005 | Surface and Coatings Technology2005，197，23： | 1 |
| 14 | Two novel BRM insertion promoter sequence variants are associated with loss of BRM expression and lung cancer risk显示文摘 | Liu G Gramling S Munoz D | 2011 | Oncogene2011，30，29： | 1 |
| 15 | Rosuvastatin added to standard heart failure therapy improves cardiac remodelling in heart failure rats with preserved ejection fraction显示文摘 | Gómez-Garre D González-Rubio ML Munoz-Pacheco P | 2010 | Eur J Heart Fail2010，12，9： | 1 |
| 16 | The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers显示文摘 | Munoz J Stange D E Schepers A G | 2012 | EMBO J2012，31，14： | 1 |
| 17 | Multiple miemabscesses in the central nervous system: a clinicopathologic study显示文摘 | Pendlebury W W Perl D P Munoz D G | 1989 | J Neumpathol Exp Neurol1989，48，3： | 1 |
| 18 | Evalu- ation of the articular cartilage of the knee joint: value of adding a T2 mapping sequence to a routine MR imaging protocol 显示文摘 | Kijowski R Blaukenbaker D G Munoz del Rio A | 2013 | Ra- diology2013，267，2： | 1 |
| 19 | An analy sis of strengthening mechanism in a mechanically alloyed,oxide dispersion strengthened iron aluminide intermetallic显示文摘 | MUNOZ MORRIS M A GARCIA C MORRIS D G | 2002 | Acta Materiallia2002，50，11： | 1 |
| 20 | Evaluationof the articular cartilage ofthe knee joint: value of addinga T2 mapping sequence to aroutine MR imaging protocol 显示文摘 | Kijowski R Blankenbaker D G Munoz D R A | 2013 | Radiology2013，267，2： | 1 |
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