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82篇 您的检索式:作者名="Mule M"
    题名 作者 年代 出处 被引量
1Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2.杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH 2004Journal of Microbiology and Immunology2004,2,4:5
2Functional evidence for GABA as modulator of the contractility of the longitudinal muscle in mouse duodenum:Role of GABA(A) and GABA(c) reeeptors显示文摘Zizzo M G Mule F Serio R 2007Neuropharmacology2007,52,8:1
3Percutaneous closure of left atrial appendage to prevent embolic events in high-risk patients with chronic atrial fibrillation显示文摘Ussia GP Mule M Cammalleri V 2009Catheter Cardiovasc Interv2009,74,:1
4Combined endothelin receptor antagonist and transcatheter interventional therapy of patent ductus arteriosus with severe pulmonary artery hypertension 显示文摘Ussia GP Mule M Caruso E 2007Int J Car- diol2007,116,3:1
5Rhino sinusal bilateral hamartoma: a case report 显示文摘PICCIOTTI P M CALO L MULE A 2008Auris Nasus Larynx2008,35,:1
6Simultaneous expression of HBME-1 and galectin-3 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid显示文摘Rossi ED Raffaelli M Mule A 2006Histopathology2006,48,7:1
7Simultaneous immunohistochemical expression of HBME-1 and galectin-3 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid 显示文摘Rossi E D Raffaelli M Mule A 2006Histopathology2006,48,7:1
8Quantitative ultrasound assessment of bone显示文摘Malavolta N Mule R Frigato M 2004Aging Clin Exp Res2004,16,3:1
9Haem othorax chylo thorax: surgical approach 显示文摘Monaco M Mule V Barresi P 2004J G Chir2004,25,89:1
10Ultrasonography detection of early bone erosions in the metacarpophalangeal joints of patients with rheumatoid arthritis显示文摘Magnani M Salizzoni E Mule R 2004Clin Exp Rheumatol2004,22,:1
11Combined endothelin receptor antagonist and transcatheter interventional therapy of patent ductus arteriosus with severe pulmonary artery hypertension显示文摘Ussia G P Mule M Caruso E 2007Int J Car- diol2007,116,3:1
12Combined endothelin recep-tor antagonist and transcatheter interventional therapy of patentductus arteriosus with severe pulmonary artery hypertension 显示文摘Ussia GP Mule M Caruso E 2007Int J Cardiol2007,116,3:1
13The valve-in-valve technique: transcatheter treatment of aortic hioprothesis malposition 显示文摘Ussia GP Mule M Tamburino C 2009Catheter Cardiovasc Interv2009,73,:1
14Percutaneous closure of left atrial appendage to prevent embolic events in high-risk patients with chronic atrial fibrillation显示文摘Ussia GP Mule M Cammalleri V 2009Catheter Cardiovasc Interv2009,74,2:1
15Percutaneous closure of left atrial appendage to prevent embolic events in high-risk patients with chronic atrial fibrillation显示文摘Ussia GP Mule M Cammalleri V 2009Catheterization and Cardiovascular Interventions2009,74,2:1
16Simultaneous immuno histo- chemical expression of H BME - 1 and galectin - 3 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid 显示文摘Rossi ED Raffaelli M Mule A 2006Histopathology2006,48,7:1
17Lactic acid bacteria growth promoters from Spirulinaplatensis显示文摘PARADA J L de CAIRE G Z de MULE M C Z 1998International Journal of Food Microbiology1998,45,3:1
18Antitumor activity of recombinant interleukin-6 in mice 显示文摘Mule J J Mcintosh J K Jablons D M 1990J Experimental Medicine1990,171,:1
19Advances in molecular diagnosis of toxigenic Fusarium species:A review显示文摘Mule G Gonzalea-Jaen M T Hornok L 2005Food Additives and Contaminants2005,22,4:1
20Quantitative ultrasound assessment of bone显示文摘Malavolta N Mule R Frigato M 2004Aging Clin Exp Res2004,16,3:1
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