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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | Properties of nisinZ and distribution of its gene,nisZ,in Lactococcus lactis显示文摘 | de Vos WM Mulders JWM Siezen RJ | 1993 | Appl Environ Microbiol1993，59，： | 1 |
| 3 | Properties of nisin Z and distribution of its gene,nis Z,in Lactococcus lactis显示文摘 | de Vos WM Mulders JW Siezen RJ | 1993 | Applied and Environmental Microbiology1993，59，1： | 1 |
| 4 | BACE1 activi ty in eerebrospinal fluid and its relation to markers of AD patholo- gY显示文摘 | Mulder SD Vander Flier WM Verheijen J H | 2010 | Alzheimers Dis2010，20，1： | 1 |
| 5 | Amyloid-beta ( 1-42 ), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease显示文摘 | Mulder C Verwey NA van der Flier WM | 2010 | Clin Chem2010，56，： | 1 |
| 6 | Muscarinic re- ceptor antagonists for overactive bladder treatment: does one fit all? 显示文摘 | Witte LP Mulder WM de la Rosette JJ | 2009 | Curt Opin Urol2009，19，： | 1 |
| 7 | Somkinng is re- lated to albuminuria and abnormal renal function in nondiabetie persons显示文摘 | Pinto-Sietsma SJ Mulder J Jannssen WM | 2000 | Ann Intern Med2000，133，8： | 1 |
| 8 | Muscarinie receptor antagonists for overactive bladder treatment:does one fit all显示文摘 | WITTE LP MULDER WM DE LA ROSETTE JJ | 2009 | Curr Opin Urol2009，19，1： | 1 |
| 9 | Smoking is related to albuminuria and abnormal renal function in nondiabetic persons 显示文摘 | Sietsma SJ Mulder J Janssen WM | 2000 | Ann Intern M ed2000，133，8： | 1 |
| 10 | Similar fecal immunochemical test results in screening and referral colorectal cancer显示文摘AIM: To improve the interpretation of fecal immunochemical test (FIT) results in colorectal cancer (CRC) cases from screening and referral cohorts. METHODS: In this comparative observational study, two prospective cohorts of CRC cases were compared. The first cohort was obtained from 10 322 average risk subjects invited for CRC screening with FIT, of which, only subjects with a positive FIT were referred for colonoscopy. The second cohort was obtained from 3637 subjects scheduled for elective colonoscopy with a positive FIT result. The same FIT and positivity threshold (OC sensor; ≥ 50 ng/mL) was used in both cohorts. Colonoscopy was performed in all referral subjects and in FIT positive screening subjects. All CRC cases were selected from both cohorts. Outcome measurements were mean FIT results and FIT scores per tissue tumor stage (T stage). RESULTS: One hundred and eighteen patients with CRC were included in the present study: 28 cases obtained from the screening cohort (64% male; mean age 65 years, SD 6.5) and 90 cases obtained from the referral cohort (58% male; mean age 69 years, SD 9.8). The mean FIT results found were higher in the referral cohort (829 ± 302 ng/mLvs 613 ± 368 ng/mL,P = 0.02). Tissue tumor stage (T stage) distribution was dif-ferent between both populations [screening population: 13 (46%) T1, eight (29%) T2, six (21%) T3, one (4%) T4 carcinoma; referral population: 12 (13%) T1, 22 (24%) T2, 52 (58%) T3, four (4%) T4 carcinoma], and higher T stage was significantly associated with higher FIT results (P < 0.001). Per tumor stage, no significant difference in mean FIT results was observed (screening vs referral: T1 498 ± 382 ng/mL vs 725 ± 374 ng/mL, P = 0.22; T2 787 ± 303 ng/mL vs 794 ± 341 ng/mL, P = 0.79; T3 563 ± 368 ng/mLvs 870 ± 258 ng/mL,P = 0.13; T4 not available). After correction for T stage in logistic regression analysis, no significant differences in mean FIT results were observed between both types of cohorts (P = 0.10). CONCLUSION: Differences in T stage distribution largely explain differences in FIT results between screening and referral cohorts. Therefore, FIT results should be reported according to T stage. | Sietze T van Turenhout Leo GM van Rossum Frank A Oort Robert JF Laheij Anne F van Rijn Jochim S Terhaar sive Droste Paul Fockens René WM van der Hulst Anneke A Bouman Jan BMJ Jansen Gerrit A Meijer Evelien Dekker Chris JJ Mulder | 2012 | World Journal of Gastroenterology2012，18，38： | 0 |
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