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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Formation of polychlorinated benzenes during the catalytic combustion of chlorobenzene using a Pt/v-Al2O3 catalyst显示文摘	R W von den Brink R Louw P Mulder	1998	Applied Catalysis B:Environmental1998，16，：	2
3	Computing interface motion in compressible gas dynamics显示文摘	Mulder W Osher S Sethian J	1992	Journal of Computational Physics1992，100，1：	2
4	Dynamic translinear circuits-An overview显示文摘	MULDER J SERJIN W A WOERD A C	2000	Analog Integrated Circuits and Signal Processing2000，22，23：	1
5	Long-term lansoprazole treatment for gastro-oesophageal reflux disease:clinical efficacy and influence on gastric mucosa显示文摘	Geboes K Dekker W Mulder CJ Nusteling K Dutch Study Group	2001	Aliment Pharmacol Ther2001，15，：	1
6	Virulence and pathogenesis of non-virulent and virulent strains of pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus显示文摘	Mulder W A Priem J Glazenburg K L	1994	J Gen Virol1994，75，1：	1
7	The SHARON process: an innovative method for nitrogen removal from ammonium-rich wastewater显示文摘	Hellinga C Schellen A A J C Mulder J W	1998	Water Science and Technology1998，37，9：	1
8	Multifunctional gold nanoparticles for diagnosis and therapy of disease显示文摘	MIESZAWSKA A J MULDER W J M FAYAD Z A	2013	Molecular pharmaceutics2013，10，3：	1
9	The SHARON process: an innovative method for nitrogen removal from ammonium-rich waste water显示文摘	Heijnen J J Heninga C Mulder J W	1998	Water Sci Teehnol1998，37，9：	1
10	Analysing container flows in Caribbean 显示文摘	VEENSTRA A W MULDER H M	2005	Journal of Transport Geography2005，13，：	1
11	Virulence and pathogenesis of non-virulent and virulent strains of pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus显示文摘	Mulder W A Priem J Glazenburg K L	1994	Journal of General Virology1994，75，1：	1
12	The SHARON process: An innovative method for nitrogen removal from ammonium- rich waste water显示文摘	Hellinga C Schellen A A J C Mulder J W	1998	Water Science and T~mology1998，37，9：	1
13	The Sharon-process: an innovative method for nitrogen removal form ammonium rich wastewater显示文摘	Hellinga C Schellen A A J C Mulder J W	1998	Water Science and Technology1998，37，9：	1
14	Full - scale application of the SHARON process for the treatment of rejection water of digested sludge dewatering 显示文摘	MULDER J W LOOSDRECHT van M C M HELLINGA C	2001	Water Sci Technol2001，43，11：	1
15	Assessment of motor recovery and decline 显示文摘	Mulder T Zijlstra W Geurts A	2002	Gait Posture2002，16，2：	1
16	Full-scale application of the SHARON process for treatment of rejection water of digested sludge dewatering显示文摘	Mulder J W van Loosdrecht M C M Hellinga C		0，，11：	1
17	Full-scale application of the SHARON process for treatment of rejection water of digested sludge dewatering显示文摘	J W Mulder M C M van Loosdrecht C Hellinga	2001	Wat Sci Tech2001，43，11：	1
18	Overview : Full scale experience of the SHARON process for treatment of rejection water of digested sludge dewatering显示文摘	Van Kempen R Mulder J W Uijterlinde C A	2001	Water Science and Technology2001，44，1：	1
19	Recombinant hor- mones : Molecular biology and biochemistry of humart recombinant follicle stimulating hormone ( Puregon ) 显示文摘	Olijve W Boer W D Mulders J W M	1996	Molecular Human Reproduction1996，2，5：	1
20	The SHARON process:An innovative method for ammonium-rich wastewater显示文摘	Hellinga C Schellen A A Mulder J W	1998	37(9) : 135-1421998，37，9：	1

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