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| 1 | Gastroenterology in developing countries:Issues and advances显示文摘Developing countries shoulder a considerable burden of gastroenterological disease. Infectious diseases in particular cause enormous morbidity and mortality. Diseases which afflict both western and developing countries are often seen in more florid forms in poorer countries. Innovative techniques continuously improve and update gastroenterological practice. However, advances in diagnosis and treatment which are commonplace in the West, have yet to reach many developing countries. Clinical guidelines, based on these advances and collated in resource-rich environments,lose their relevance outside these settings. In this two-part review, we first highlight the global burden of gastroenterological disease in three major areas: diarrhoeal diseases, hepatitis B, and Helicobacter pylori . Recent progress in their management is explored, with consideration of future solutions. The second part of the review focuses on the delivery of clinical services in developing countries. Inadequate numbers of healthcare workers hamper efforts to combat gastroenterological disease. Reasons for this shortage are examined, along with possibilities for increased specialist training. Endoscopy services, the mainstay of gastroenterology in the West, are in their infancy in many developing countries. The challenges faced by those setting up a service are illustrated by the example of a Nigerian endoscopy unit. Finally, we highlight the limited scope of many clinical guidelines produced in western countries. Guidelines which take account of resource limitations in the form of 'cascades' are advocated in order to make these guidelines truly global. Recognition of the different working conditions facing practitioners worldwide is an important step towards narrowing the gap between gastroenterology in rich and poor countries. | Kate L Mandeville Justus Krabshuis Nimzing Gwamzhi Ladep Chris JJ Mulder Eamonn MM Quigley Shahid A Khan | 2009 | World Journal of Gastroenterology2009，15，23： | 8 |
| 2 | Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorigenesis显示文摘 | Mulder JW Wielenga VJ Polak MM | 1995 | Cut1995，36，5： | 1 |
| 3 | Expression of mutant p53 protein and CD44 variant proteins in colorectal tumorgenesis显示文摘 | Mulder JWR Wielenga VTM Polak MM | 1995 | Gut1995，36，1： | 1 |
| 4 | A newborn with congenital complete atrioventricular block, lissencephaly, and skeletal abnormalities: A case of suspected cytomegalovirus infection显示文摘 | Mulder TJ Niyazov DM Kattash MM | 2010 | Congenit Heart Dis2010，5，5： | 1 |
| 5 | Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma显示文摘 | Hoefnagel JJ Mulder MM Dreef E | 2006 | Mod Pathol2006，19，9： | 1 |
| 6 | Temperature-controlled radiofrequency energy (SECCA) to the anal canal forthe treatment of faecal incontinence offers moderateimprovement 显示文摘 | Felt-Bersma RJ Szojda MM Mulder CJ | 2007 | Eur J Gastroenterol Hepatol2007，19，： | 1 |
| 7 | Acute pulmonary histoplasmosis from Ghana显示文摘 | de Vries PJ Koolen MG Mulder MM | 2006 | Travel Med Infect Dis2006，4，5： | 1 |
| 8 | Review article: Management of diverticulitis 显示文摘 | Szojda MM Cuesta MA Mulder CM | 2007 | Aliment Pharmacol Ther2007，26，2： | 1 |
| 9 | No evidence for an association of ocular adnexal lymphoma with Chlamydia psittaci in a cohort of patients from the Netherlands显示文摘 | Mulder MM Heddema ER Pannekoek Y | 2006 | Leuk Res2006，30，： | 1 |
| 10 | Population pharmacokinet- ics of nevirapine in an unselected cohort of HIV-1-infected individuals 显示文摘 | Maat MM Huitema AD Mulder JW | 2002 | Br J Clin Pharmacol2002，54，4： | 1 |
| 11 | Expression ofMutant p53 Protein and CD44 Variant Proteins inColorectal Tumorignesis显示文摘 | Wielenga VJ Polok MM | 1995 | Gut1995，136，： | 1 |
| 12 | Expression mutant p53 protein and CD44v6 variant protein in colorectum origenesis显示文摘 | Wielenga VJ Polak MM | 1995 | J Gut1995，36，1： | 1 |
| 13 | Expression of mutant P53 protein and CD44 variant proteins in colorectal tumorigenesis 显示文摘 | Mulder JWR Weilenga VJM Polak MM | 1995 | Gut1995，36，： | 1 |
| 14 | Expression of mutant P53 protein and CD44 variant protein in colorectal tumorigenesis显示文摘 | Mulder JW Wielenga VJ Polak MM | 1995 | Gut1995，36，1： | 1 |
| 15 | No evidence for an association of ocular adnexal lymphoma with Chlamydia psittaci in a cohort of patients from the Netherlands 显示文摘 | Mulder MM Heddema ER Pannekoek Y | 2006 | Leuk Res2006，30，： | 1 |
| 16 | Temperature-con- trolled radiofrequency energy (SECCA) to the anal canal for the treatment of faecal incontinence offers moderale improvement 显示文摘 | Felt-Bersma RJ Szojda MM Mulder CJ | 2007 | Eur J Gastroenterol Hepatol2007，19，： | 1 |
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