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| 1 | 三腔连续负压引流管在感染性坏死性胰腺炎外科治疗中的临床疗效显示文摘目的急性胰腺炎(acute pancreatitis,AP)是一种发病率和病死率均较高的炎症性疾病,部分AP患者会演变为重症急性胰腺炎(severe acute pancreatitis,SAP)。SAP病程后期常伴有感染性胰腺坏死,这类患者病死率极高。感染性坏死性胰腺炎(infected necrotizing pancreatitis,INP)是接受外科治疗的重要指征之一,外科医师对INP干预时机、策略及方式的掌控尤为重要,本研究的目的是探讨三腔连续负压引流这一新技术对于INP患者外科治疗能否带来更好的疗效。方法回顾性分析2009年1月至2019年12月在我院通过增强CT或细针穿刺活检被诊断为INP的60例患者,这些患者均经过14 d标准化的保守治疗但病情未能明显改善。其中30例患者通过植入三腔连续负压引流管接受了外科减压治疗,而另外30例患者延续保守治疗。通过软件分析60例患者的临床资料及其他能够预示临床疗效的指标。结果三腔连续负压引流管的外科减压手术组,患者的病死率显著降低,30例患者中8例死亡(26.7%);保守治疗组出现11例死亡(36.7%),两组患者病死率具有统计学差异(P<0.05)。此外,外科减压组患者的其他病理生理指标,包括腹内压、呼吸功能、肾功能等,较保守治疗组也有显著改善。结论急性INP患者在接受保守治疗14 d后,可以使用三腔连续负压引流管的减压手术,该手术在减少病死率和改善病理生理指标方面具有显著疗效。 | Muhammad Salman Azhar 孙吉春 聂晚频 李志强 朱红伟 刘云飞 余枭 李霞 | 2020 | 邵阳学院学报(自然科学版)2020，17，5： | 2 |
| 2 | Genetic effects conferring heat tolerance in upland cotton(Gossypium hirsutum L.)显示文摘Background:Climate change and particularly global warming has emerged as an alarming threat to the crop productivity of field crops and exerted drastic effects on the cropping patterns.Production of cotton has been dropped down to one million bales from 1.4 million bales since 2015 in Pakistan due to the increase in temperature at critical growth stages,i.e.,flowering and boll formation.Keeping in view the importance of cotton in the country,this study was conducted to investigate the genetic effects conferring heat tolerance in six populations(P1,P2,F1,F2,BC1 and BC2)developed from cross-1 and cross-2,i.e.,VH-282×FH-142 and DNH-40×VH-259.Results:The results revealed that cross-1 performed better in heat stress as compared with cross-2 for majority of the traits recorded.Boll weight and ginning outturn(GO-T)were highly effected under heat stress and had negative correlation with Relative cell injury(RCI).Boll weight,fiber length,fiber strength and fiber fineness were under the control of non-additive gene action,whereas RCI was controlled by additive gene effects.Lower values of genetic advance coupled with higher values of broad sense heritability for these traits except RCI confirmed the role of non-additive genetic effects.Duplicate types of epistasis were recorded for fiber strength in cross-1 in normal condition.However,complementary type of non-allelic interaction was recorded for fiber strength under normal condition,fiber fineness and RCI under heat stressed condition in cross-1.Likewise,boll weight,GOT and fiber length in populations derived from cross-2 in normal condition were also under the influence of complementary type of non-allelic interaction.Significant differences among values of mid parent and better parent heterosis for boll weight in both normal and heat stress condition provided the opportunity to cotton breeders for utilization of this germplasm for improvement of this trait through exploitation of heterosis breeding.Conclusion:Cross-1 performed better in heat stress and could be utilized for development of heat tolerant cultivar.RCI was under the influence of additive gene action,so one can rely on this trait for screening of large number of accessions of cotton for heat stress.While other traits were predominantly controlled by non-additive gene action and selection based on these should be delayed in later generations. | SALMAN Muhammad ZIA Zia Ullah RANA Iqrar Ahmad MAQSOOD Rana Haroon AHMAD Saghir BAKHSH Ali AZHAR Muhammad Tehseen | 2019 | Journal of Cotton Research2019，2，1： | 2 |
| 3 | Genetics of biochemical attributes regulating morpho-physiology of upland cotton under high temperature conditions显示文摘Background Cotton is a strategically important fibre crop for global textile industry.It profoundly impacts several countries’industrial and agricultural sectors.Sustainable cotton production is continuously threatened by the unpre-dictable changes in climate,specifically high temperatures.Breeding heat-tolerant,high-yielding cotton cultivars with wide adaptability to be grown in the regions with rising temperatures is one of the primary objectives of modern cotton breeding programmes.Therefore,the main objective of the current study is to figure out the effective breed-ing approach to imparting heat tolerance as well as the judicious utilization of commercially significant and stress-tolerant attributes in cotton breeding.Initially,the two most notable heat-susceptible(FH-115 and NIAB Kiran)and tolerant(IUB-13 and GH-Mubarak)cotton cultivars were spotted to develop filial and backcross populations to accom-plish the preceding study objectives.The heat tolerant cultivars were screened on the basis of various morphological(seed cotton yield per plant,ginning turnout percentage),physiological(pollen viability,cell membrane thermostabil-ity)and biochemical(peroxidase activity,proline content,hydrogen peroxide content)parameters.Results The results clearly exhibited that heat stress consequently had a detrimental impact on every studied plant trait,as revealed by the ability of crossing and their backcross populations to tolerate high temperatures.However,when considering overall yield,biochemical,and physiological traits,the IUB-13×FH-115 cross went over particularly well at both normal and high temperature conditions.Moreover,overall seed cotton yield per plant exhibited a posi-tive correlation with both pollen viability and antioxidant levels(POD activity and proline content).Conclusions Selection from segregation population and criteria involving pollen viability and antioxidant levels concluded to be an effective strategy for the screening of heat-tolerant cotton germplasms.Therefore,understanding acquired from this study can assist breeders identifying traits that should be prioritized in order to develop climate resilient cotton cultivars. | MAJEED Sajid CHAUDHARY Muhammad Tanees MUBARIK Muhammad Salman RANA Iqrar Ahmad SHABAN Muhammad TAN Daniel KY JIA Yinhua DU Xiongming HINZE Lori AZHAR Muhammad Tehseen | 2024 | Journal of Cotton Research2024，7，1： | 0 |
| 4 | Genome editing in cotton:challenges and opportunities显示文摘Cotton has enormous economic potential providing high-quality protein,oil,and fibre.A large increase in cotton output is necessary due to the world’s changing climate and constantly expanding human population.In the past,conventional breeding techniques were used to introduce genes into superior cotton cultivars to increase production and to improve quality.The disadvantages of traditional breeding techniques are their time-consuming,reliance on genetic differences that are already present,and considerable backcrossing.To accomplish goals in a short amount of time,contemporary plant breeding techniques,in particular modern genome editing technologies(GETs),can be used.Numerous crop improvement initiatives have made use of GETs,such as zinc-finger nucleases,transcription-activator-like effector nucleases,clustered regularly interspaced palindromic repeats(CRISPR),and CRISPR-associated proteins systems(CRISPR/Cas)-based technologies.The CRISPR/Cas system has a lot of potential because it combines three qualities that other GETs lack:simplicity,competence,and adaptability.The CRISPR/Cas mechanism can be used to improve cotton tolerance to biotic and abiotic stresses,alter gene expression,and stack genes for critical features with little possibility of segregation.The transgene clean strategy improves CRISPR acceptability addressing regulatory issues associated with the genetically modified organisms(GMOs).The research opportunities for using the CRISPR/Cas system to address biotic and abiotic stresses,fibre quality,plant architecture and blooming,epigenetic changes,and gene stacking for commercially significant traits are highlighted in this article.Furthermore,challenges to use of CRISPR technology in cotton and its potential for the future are covered in detail. | KHAN Zulqurnain KHAN Sultan Habibullah AHMED Aftab IQBAL Muhammad Umar MUBARIK Muhammad Salman GHOURI Muhammad Zubair AHMAD Furqan YASEEN Saba ALI Zulfiqar KHAN Asif Ali AZHAR Muhammad Tehseen | 2023 | Journal of Cotton Research2023，6，1： | 0 |
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