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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Uniform Metal Nanotube Arrays by Multistep Template Replication and Electrodeposition显示文摘 | Yu Y X Wang R M | 2004 | Adv Mater2004，16，17： | 1 |
| 3 | Analysis of the impact of conservation measures on streamflow regime in catchments of the Loess Plateau, China 显示文摘 | Mu X M Zhang L McVicar T R | 2007 | Hydrological Processes2007，，21： | 1 |
| 4 | Sebaceus naevi:a clinicopathologic study显示文摘 | Mu(n)oz-Pérez MA García-Hernandez MJ Ríos JJ | 2002 | J Eur Acad Dermatol Venereol2002，16，4： | 1 |
| 5 | Adipokine resistin promotes in vitro angiogenesis of human endothelial cells显示文摘 | Mu H Ohashi R Yan S | 2006 | Cardiovasc Res2006，70，1： | 1 |
| 6 | Nitrobenzene removal in bioelectrochemical systems 显示文摘 | Mu Y Rozendal R A Rabaey K | 2009 | Environmental Science and Technology2009，43，22： | 1 |
| 7 | Elevated serum interleukin 33 is associated with autoantibody production in patients with rheumatoid arthritis显示文摘 | Mu R Huang HQ Li YH | | 0，，： | 1 |
| 8 | Lipid-based formulations for oral administration of poorly water-soluble drugs 显示文摘 | Mu H Holm R Mtillertz A | 2013 | Int J Pharm2013，453，1： | 1 |
| 9 | Elevated serum interleukin 33 is associated with autoantibody production in patients with rheumatoid arthritis显示文摘 | Mu R Huang HQ Li YH | 2010 | J Rheumatol2010，37，10： | 1 |
| 10 | Seasonal morphological and biochemical changes of Dahlgren cells implies a potential role of the caudal neurosecretory system (CNSS) in the reprodu- ction cycle of teleostean fish显示文摘 | Chen H Mu R | 2008 | Fish Physiology and Biochemistry2008，34，1： | 1 |
| 11 | Total homocysteine in plasma or serum: methods and clinical implications 显示文摘 | Per MU Helga R Sally P S | 1993 | Clin Chem1993，39，： | 1 |
| 12 | Baicalein exerts neuroprotectire effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro显示文摘 | Mu X He G R Cheng Y X | 2009 | Pharmacol Biochem Behav2009，92，4： | 1 |
| 13 | Regional evaporation estimates from flux tower and MODIS satellite data显示文摘 | Cleugh H A Leuning R Mu Q Z | 2007 | Remote Sensing of Environment2007，106，： | 1 |
| 14 | Estima- ting the impact of conservation measures on stream-flow regime in catchments of the Loess Plateau, China显示文摘 | Mu Xingmin Zhang Lu McVicar T R | 2007 | Hydrological Progress2007，21，16： | 1 |
| 15 | Best model augmentation for varia- ble-structure multiple-model estimation 显示文摘 | Lan J Li X R Mu C D | 2011 | IEEE Transac- tions on Aerospace and Electronic Systems2011，47，3： | 1 |
| 16 | Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis显示文摘 | Liu Y Mu R Wang S | 2010 | Arthritis Res Ther2010，12，6： | 1 |
| 17 | Indoor air pollution and risk of lung cancer among Chinese female non-srnoker显示文摘 | Mu L Liu L Niu R | 2013 | Cancer Causes Control2013，24，3： | 1 |
| 18 | Prognostic value of HIV-1 RNA,CD4 cell count,and CD4 Cell count slope for progression to AIDS and death in untreated HIV-1infection显示文摘 | Mellors J W Margolick J B Phair J P Rinaldo C R Detels R Jacobson L P Mu noz A | 2007 | JAMA2007，297，21： | 1 |
| 19 | Inhibition of Newcastle disease virus replication by RNA interference targeting the matrix protein gene in chicken embryo fibroblasts显示文摘 | Yin R Ding Z Liu X Mu L Cong Y Stoeger T | 2010 | J Virol Methods2010，167，1： | 1 |
| 20 | Hypoxia and hypoxia-induciblefactor-la provoke toll-like receptor signalling-induced inflam-mation in rheumatoid arthritis显示文摘 | Hu F Mu R Zhu J | 2014 | Ann Rheum Dis2014，73，： | 1 |
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