|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin显示文摘LRP16 以前在乳癌房间作为导致雌激素的基因被识别。到在子宫内膜的癌症(EC ) 的雌激素和它的功能的效果的 LRP16 的应答的海角房间仍然是不清楚的。这里,我们证明 LRP16 基因的信使 rna 水平和倡导者活动被 17beta-estradiol (E2 ) 显著地在雌激素受体高山增加哈(嗯高山哈)-positiveIshikawa 人 EC 房间。尽管 Ishikawa 细胞的生长率没被 LRP16 的宫外的表示显然影响, Transwell 试金的结果显示出 LRP16-overexpressing 细胞的侵略能力的近似 one-thirdincrease。由于分子的屏蔽,我们观察到 E-cadherin 的表示,与肿瘤转移联系的一个必要粘附分子,被 LRP16 镇压。进一步的倡导者分析以一种剂量依赖者方式表明了那 LRP16 inhibitedE-cadherin transactivation。然而,抑制被雌激素剥夺废除,显示由 LRP16requires 的 E-cadherin 抄写的 down 规定嗯高山哈调停。染色质免疫降水分析表明到 E-cadherin 倡导者的 ERalpha 的绑定被 LRP16 反对,建议那 LRP16 能防碍嗯调停 alpha 的抄写。这些结果建议起来由雌激素的 LRP16 的规定能被在人的 EC 调整 E-cadherin 的 down 涉及侵略生长。 | Yuan Guang Meng Wei Dong Han Ya Li Zhao Ke Huang Yi Ling Si Zhi Qiang Wu Yi Ming Mu | 2007 | Cell Research2007，17，10： | 27 |
| 2 | Preliminary molecular epidemiology of the Staphylococcus aureus in lower respiratory tract infections: a multicenter study in China显示文摘 | LI De-zhi CHEN Yu-sheng YANG Jing-ping ZHANG Wei HU Cheng-ping LI Jia-shu MU Lan HU Ying-hui GENG Rong HU Ke CAI Shao-xi WAN Huan-ying WANG Qiu-yue WEI Li-ping DU Juan YU Qin ZHONG Xiao-ning WANG Rui-qin MA Jian-jun TIAN Gui-zhen WANG Si-qin GAO Zhan-cheng | 2011 | Chinese Medical Journal2011，，5： | 21 |
| 3 | Ectopic osteogenesis and angiogenesis regulated by porous architecture of hydroxyapatite scaffolds with similar interconnecting structure in vivo显示文摘The macro-pore sizes of porous scaffold play a key role for regulating ectopic osteogenesis and angiogenesis but many researches ignored the influence of interconnection between macro-pores with different sizes.In order to accurately reveal the relationship between ectopic osteogenesis and macro-pore sizes in dorsal muscle and abdominal cavities of dogs,hydroxyapatite(HA)scaffolds with three different macro-pore sizes of 500–650,750–900 and 1100–1250 mm were prepared via sugar spheres-leaching process,which also had similar interconnecting structure determined by keeping the d/s ratio of interconnecting window diameter to macro-pore size constant.The permeability test showed that the seepage flow of fluid through the porous scaffolds increased with the increase of macro-pore sizes.The cell growth in three scaffolds was not affected by the macro-pore sizes.The in vivo ectopic implantation results indicated that the macro-pore sizes of HA scaffolds with the similar interconnecting structure have impact not only the speed of osteogenesis and angiogenesis but also the space distribution of newly formed bone.The scaffold with macro-pore sizes of 750–900 mm exhibited much faster angiogenesis and osteogenesis,and much more uniformly distribution of new bone than those with othermacro-pore sizes.This work illustrates the importance of a suitable macro-pore sizes in HA scaffolds with the similar interconnecting structure which provides the environment for ectopic osteogenesis and angiogenesis. | Jinyu Li Wei Zhi Taotao Xu Feng Shi Ke Duan JianxinWang Yandong Mu Jie Weng | 2016 | Regenerative Biomaterials2016，3，5： | 16 |
| 4 | UDP-glucose pyrophosphorylase2 (OsUgp2), a pollen-preferential gene in rice, plays a critical role in starch accumulation during pollen maturation显示文摘UDP-glucose pyrophosphorylase (UGPase) is predominantly present and plays significant role in carbohydrate metabolism in plants. Two homologous UGPase genes, OsUgp1 and OsUgp2, exist in rice genome. OsUgp1 has recently been reported to be essential for callose deposition during pollen mother cell and meiosis stages as well as for seed carbohydrate metabolism. In this study, a full-length cDNA of OsUgp2 was isolated from rice anther. Northern blot and RNA in situ hybridization indicated that the expression of OsUgp2 was preferentially in pollen and developmentally regulated. No transcripts were found in leaf, stem, lemma/palea, ripening grain and florets before the uninucleate microspore developmental stage, but a large quantity of OsUgp2 mRNA was found in pollen at the binucleate and mature stages. The immunolocalization of OsUgp2 showed a similar expression pattern to that by RNA in situ hybridization. The function of OsUgp2 was investigated by dsRNA-mediated transcriptional gene silencing. The pollen fertility of 16 independent transgenic rice plants was found between 25% and 90%, which was correlated with the amount of OsUgp2 mRNA. The results of morphological changes and starch variation during pollen development in transgenic rice showed that the abnormal feature of pollen development appeared after the uninucleate microspore stage. Starch failed to accumulate in pollen and thus led to sterile pollens. These results demonstrated that OsUgp2 is a pollen-preferential 'late gene' and plays a key role during pollen maturation, especially for starch accumulation. OsUgp2 complements OsUgp1 to fulfill the UGPase’s functions necessary for the full process of pollen development. | MU Hong KE JianHao LIU Wei ZHUANG ChuXiong YIP WingKin | 2009 | Chinese Science Bulletin2009，54，2： | 15 |
| 5 | Ginsenoside Rg1 enhances the resistance of hematopoietic stem/progenitor cells to radiation- induced aging in mice显示文摘 | Cui CHEN Xin-yi MU Yue ZHOU Ke SHUN Shan GENG Jun LIU Jian-wei WANG Jie CHEN Tin-yu LI Ya-ping WANG | 2014 | Acta Pharmacologica Sinica2014，35，1： | 15 |
| 6 | Overexpression of potato miR482e enhanced plant sensitivity to Verticillium dahliae infection显示文摘Verticillium wilt of potato is caused by the fungus pathogen Verticillium dahliae. Present s RNA sequencing data revealed that miR482 was in response to V. dahliae infection but the function in potato is elusive. Here, we characterized potato miR482 family and its putative role resistance to Verticillium wilt. Members of the potato mi R482 superfamily are variable in sequence, but all variants target a class of disease-resistance proteins with nucleotide binding site(NBS)and leucine-rich repeat(LRR) motifs. When potato plantlets were infected with V. dahliae, the expression level of miR482e was downregulated, and that of several NBS-LRR targets of miR482e were upregulated. Transgenic potato plantlets overexpressing miR482e showed hypersensitivity to V. dahliae infection. Using s RNA and degradome datasets, we validated that miR482e targets m RNAs of NBS-LRR disease-resistance proteins and triggers the production of trans-acting(ta)si RNAs, most of which target m RNAs of defense-related proteins. Thus, the hypersensitivity of transgenic potato could be explained by enhanced miR482e and miR482e-derived tasi RNA-mediated silencing on NBS-LRR-disease-resistance proteins. It is speculated that a miR482-mediated silencing cascade mechanism is involved in regulating potato resistance against V. dahliae infection and could be a counter defense action of plant in response to pathogen infection. | Liu Yang Xiaoying Mu Chao Liu Jinghui Cai Ke Shi Wenjiao Zhu Qing Yang | 2015 | Journal of Integrative Plant Biology2015，57，12： | 14 |
| 7 | Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection显示文摘 | DAI Ning LI De-zhi CHEN Ji-chao CHEN Yu-sheng GENG Rong HU Ying-hui YANG Jing-ping DU Juan HU Cheng-ping ZHANG Wei LI Jia-shu YU Qin WAN Huan-ying MU Lan ZHONG Xiao-ning WEI Li-ping MA Jian-jun WANG Qiu-yue HU Ke TIAN Gui-zhen CAI Shao-xi WANG Rui-qin HE Bei WANG Si-qin WANG Zhan-wei ZHAO Su-rui GAO Zhan-cheng | 2010 | Chinese Medical Journal2010，，18： | 13 |
| 8 | In Situ Corrosion Monitoring of Mild Steel in a Simulated Tidal Zone without Marine Fouling Attachment by Electrochemical Impedance Spectroscopy显示文摘The corrosion behaviors of the isolated short and vertical long scale Q235 B steel in a simulated tidal zone were studied by electrochemical impedance spectroscopy(EIS) monitoring and corrosion weight loss calculation in an experimental indoor simulating trough.The results show that the corrosion rate of the isolated short scale Q235 B steel in the tidal zone acquired by the EIS agrees with the corrosion weight loss result.The corrosion rates of the short scale steel are in the order of middle tidal zone > the central zone between the middle tidal zone and low tidal zone > high tidal zone > low tidal zone.The fastest corrosion rate in the middle tidal zone is attributed to the longest wet time in a tidal cycle.According to the comparison of corrosion weight loss between the vertical long scale and isolated short scale specimens,the corrosion rate of vertical long scale specimens of Q235 B steel is lower than that of the isolated short scale specimens in the tidal zone,but the result is contrary in the immersion zone. | Xin Mu Jie Wei Junhua Dong Wei Ke | 2014 | Journal of Materials Science & Technology2014，30，10： | 11 |
| 9 | Sonographic appearance of anal cushions of hemorrhoids显示文摘AIM To evaluate the diagnostic value of different sonographic methods in hemorrhoids.METHODSForty-two healthy volunteers and sixty-two patients with gradesⅠ-Ⅳhemorrhoids received two different sonographic examinations from January 2013 to January2016 at the First and Second Hospitals of Xinjiang Medical University in a prospective way.We analyzed the ultrasonographic findings of these participants and evaluated the outcomes.Resected gradesⅢandⅣhemorrhoid tissues were pathologically examined.The concordance of ultrasonographic results with pathologyresults was assessed with the Cohen’s kappa coefficient.RESULTS All healthy volunteers and all patients had no particular complications related to sonography.There were no statistically significant differences between the participants regarding age(P=0.5919),gender(P=0.4183),and persistent symptoms(P>0.8692).All healthy control participants had nospecial findings.However,30 patients with hemorrhoids showed blood signals around the dentate line on ultrasonography.When gradesⅠandⅡhemorrhoids were analyzed,there were no significant differences between transrectal ultrasound(TRUS),transperianal ultrasound(TPUS),and transvaginal ultrasound(TVUS)(P>0.05).GradesⅢandⅣhemorrhoids revealed blood flow with different directions which could be observed as a'mosaic pattern'.In patients with gradesⅢandⅣhemorrhoids,the number of patients with'mosaic pattern'as revealed by TRUS,TPUS and TVUS was 22,12,and 4,respectively.Patients with gradesⅢandⅣdisease presented with a pathologically abnormal cushion which usually appeared as a'mosaic pattern'in TPUS and an arteriovenous fistula in pathology.Subepithelial vessels of resected gradesⅢandⅣhemorrhoid tissues were manifested by obvious structural impairment and retrograde and ruptured changes of internal elastic lamina.Some parts of the Trietz’s muscle showed hypertrophy and distortion.Arteriovenous fistulas and venous dilatation were obvious in the anal cushion of hemorhoidal tissues.After pathological results with arteriovenous fistulas were taken as the standard reference,we evaluated the compatibility between the two methods according to the Cohen’s kappa coefficiency calculation.The compatibility(Cohein kappa co-efficiency value)between'mosaic pattern'in the TPUS and arteriovenous fistula in pathology was very good(?=0.8939).When compared between different groups,TRUS presented the advantage that the mosaic pattern could be confirmed in more patients,especially for group A.There was a statistical difference when comparing group A with group B or C(P<0.05 for both).There were obvious statistical differences between group A and group B with regard to the vessel diameter and blood flow velocity measured by TRUS(P<0.05).CONCLUSION Patients with gradesⅢandⅣhemorrhoids present with a pathologically abnormal cushion which usually appears as a'mosaic pattern'in sonography,which is in accord with an arteriovenous fistula in pathology.There are clearly different hemorrhoid structures shown by sonography.'Mosaic pattern'may be a parameter for surgical indication of gradesⅢandⅣhemorrhoids. | Adilijiang Aimaiti Ma Mu Ti Jiang A Ba Bai Ke Re Irshat Ibrahim Hui Chen Maimaitituerxun Tuerdi Mayinuer | 2017 | World Journal of Gastroenterology2017，23，20： | 11 |
| 10 | Insight into atmospheric corrosion evolution of mild steel in a simulated coastal atmosphere显示文摘The corrosion behavior of mild steel in a simulated coastal atmosphere environment has been investigated by the indoor accelerated wet/dry cyclic corrosion acceleration test(CCT),scanning electron microscopy(SEM),Raman spectroscopy and electrochemical measurements.During the CCT test of 60 cycles,the evolution of logarithmic(corrosion rate)vs.logarithmic(CCT cycles)presents a turning point at the 5th cycle,presenting a tendency to increase first and then decrease to gradually stabilize as the CCT cycle prolonged.Before the 5th cycle,γ-FeOOH andβ-FeOOH and Fe_(3)O_(4)were detected,respectively.And then,α-FeOOH as a new chemical composition was detected in the subsequent corrosion cycles.It is found that,after long term corrosion,the rust separated into a relatively dense inner layer rich withα-FeOOH and a loose outer layer rich withγ-FeOOH,both of which have poor electrical conductivity.The rapid increase of corrosion rate in the early stage since reducible corrosion products are involved in the reduction process of the cathode which promotes the dissolution of the anodic metal substrate.Afterward,as the rust layer thickens,the resistance of the rust increases,and the aggressive ions diffusion is blocked,gradually suppressing the electrochemical corrosion process.At last,when the composition and distribution of the rust layer remain stable,the corrosion presents a fluctuating speed around a certain value during the cracking and self-repairing process of the rust layer. | Yue Wang Xin Mu Junhua Dong Aniefiok Joseph Umoh Wei Ke | 2021 | Journal of Materials Science & Technology2021，，17： | 7 |
| 11 | Effect of tin addition on corrosion behavior of a low-alloy steel in simulated costal-industrial atmosphere显示文摘The effect of tin addition on the atmospheric corrosion behavior of a low-alloy steel in sim ulated coastalindustrial atm osphere has been investigated by indoor wet/dry cyclic corrosion test (CCT). The results indicate that tin addition can obviously make the steel substrate more resistant to atmospheric corrosion by suppressing the cathodic H^+ reduction reaction, and but tin addition is not of obvious beneficial effect when the steel is covered with a thicker rust layer during long-term corrosion process. The reason lies in the fact that the presence of un-reduced H^+ can lower the electrolyte pH value and lead to a loose and porous rust layer on tin-containing steel sample than that on tin-free steel sample. In addition, the 120 CCT cycles corrosion process of the two steels can be divided into three stages. Both the tin-free and tin-containing steels show an increasing corrosion rate during the initial corrosion stage and then exhibit a decreasing corrosion rate during the second and third corrosion stages. Moreover, tin addition makes the tin-containing steel rust layer have a higher amount of α-FeOOH and lower am ount of γ-FeOOH and Fe3O4 than the tin-free steel rust layer. | Bo Liu Xin Mu Ying Yang Long Hao Xueyong Ding Junhua Dong Zhe Zhang Huaxing Hou Wei Ke | 2019 | Journal of Materials Science & Technology2019，35，7： | 6 |
| 12 | High Performance Speech Compression System显示文摘Since Pulse Code Modulation emerged in 1937, digitized speech has experienced rapid development due to its outstanding voice quality, reliability, robustness and security in communication. But how to reduce channel width without loss of speech quality re-mains a crucial problem in speech coding theory. A new full-duplex digital speech communication system based on the Vocoder of AMBE- 1 000TM and microcontroller ATMEL 89C5 1 is introduced. It shows higher voice quality than current mobile phone system with only a quarter of channel width needed for the latter. The prospective areas in which the system can be applied include satellite communication, IP Phone, virtual meeting and the most important, defence industry. | Ke Liu, Zhichun Mu, Zhong Wang Information Engineering School, University of Science & Technology Beijing, Beijing 100083, China | 2001 | Journal of University of Science and Technology Beijing2001，8，3： | 6 |
| 13 | High levels of circulating GM-CSF^(+) CD4^(+) T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study显示文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients. | Huihuang Huang Siyu Wang Tianjun Jiang Rong Fan Zheng Zhang Jinsong Mu Ke Li Yonggang Wang Lei Jin Fang Lin Jie Xia Lijian Sun Biao Xu Chengcheng Ji Jing Chen Juan Chang Bo Tu Bing Song Chao Zhang Fu-Sheng Wang Ruonan Xu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 14 | Effect of glycine addition on the in-vitro corrosion behavior of AZ31 magnesium alloy in Hank’s solution显示文摘This study reports on the effect of the addition of Glycine to Hank’s solution on the in-vitro corrosion behavior of AZ31 magnesium(Mg)alloy at 37℃and a pH of 7.4 studied by using potentiodynamic polarization(PDP),hydrogen collecting techniques and electrochemical impedance spectroscopy(EIS)in combination with surface characterization techniques such as optical microscopy(OM),scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),X-ray diffraction(XRD)and X-ray photoelectron spectroscopy analysis(XPS).The results reveal that adsorption of glycine initially subdues the dissolution of AZ31 Mg alloy while in long run it enhances the dissolution of the alloy due to the commencement of the chelation effect of glycine with Ca^(2+) released from hydroxyapatite.The chelation of glycine with Ca^(2+) induces the formation of cracks in the surface film which further promotes the dissolution of AZ31 Mg alloy thereby forming a porous corrosion products layer on the surface of the alloy.As a result,both the continuous dissolution of AZ31 magnesium alloy and the hydrogen evolution rate(HER)are enhanced with increasing the immersion time in Hank’s solution. | Durga Bhakta Pokharel Liping Wu Junhua Dong Amar Prasad Yadav Dhruba Babu Subedi Madhusudan Dhakal Lin Zha Xin Mu Aniefiok Joseph Umoh Wei Ke | 2021 | Journal of Materials Science & Technology2021，，22： | 4 |
| 15 | Flexible Waterproof Piezoresistive Pressure Sensors with Wide Linear Working Range Based on Conductive Fabrics显示文摘Developing flexible sensors with high working performance holds intense interest for diverse applications in leveraging the Internet-of-things(IoT)infrastructures.For flexible piezoresistive sensors,traditionally most efforts are focused on tailoring the sensing materials to enhance the contact resistance variation for improving the sensitivity and working range,and it,however,remains challenging to simultaneously achieve flexible sensor with a linear working range over a high-pressure region(>100 kPa)and keep a reliable sensitivity.Herein,we devised a laserengraved silver-coated fabric as'soft'sensor electrode material to markedly advance the flexible sensor's linear working range to a level of 800 kPa with a high sensitivity of 6.4 kPa^-1 yet a fast response time of only 4 ms as well as long-time durability,which was rarely reported before.The integrated sensor successfully routed the wireless signal of pulse rate to the portable smartphone,further demonstrating its potential as a reliable electronic.Along with the rationally building the electrode instead of merely focusing on sensing materials capable of significantly improving the sensor's performance,we expect that this design concept and sensor system could potentially pave the way for developing more advanced wearable electronics in the future. | Hongcheng Xu Libo Gao Yuejiao Wang Ke Cao Xinkang Hu Liang Wang Meng Mu Min Liu Haiyan Zhang Weidong Wang Yang Lu | 2020 | Nano-Micro Letters2020，12，11： | 4 |
| 16 | Tetrandrine inhibits proliferation of colon cancer cells by BMP9/PTEN/PI3K/AKT signaling显示文摘Despite advances in screening and treatment,colon cancer remains one of the leading causes of cancer-related death.Finding novel and useful drug treatment targets is also an urgent need for clinical applications.Tetrandrine(Tet)is extracted from the Chinese medicinal herbal medicine,which is a well-known calcium blocker with a variety of pharmacological activities,including anti-cancer.In this study,we recruited cell viability assay,flow cytometry analysis,cloning formation to confirm that Tet can inhibit the proliferation of SW620 cells,and induce apoptosis.Mechanically,we confirmed that Tet up-regulates the mRNA and protein level of BMP9 in SW620 cells.Over-expression BMP9 enhances the anticancer effects of Tet in SW620 cells,but these effects can be partly reversed by silencing BMP9.Also,Tet reduces phosphorylation of Aktl/2/3 in SW620 cells,which could be elevated by overexpressed BMP9 and impaired by silencing BMP9.Furthermore,we demonstrated that Tet reduces phosphorylated PTEN,which can be promoted by overexpressed BMP9,analogously also be attenuated through silencing BMP9.Finally,we introduced a xenograft tumor model to investigate the anti-proliferative effect of Tet,further to explore the effects of BMP9 and PTEN in SW620 cells.Our findings suggested that the anti-cancer activity of Tet in SW620 cells may be mediated partly by up-regulating BMP9,followed by inactivation PI3K/Akt through up-regulating PTEN at least. | Ya Zhou Li Mu Xiao-Lu Liu Qin Li Li-Xuan Ding Hong-Chuan Chen Ying Hu Fu-Shu Li Wen-Juan Sun Bai-Cheng He Ke Wu | 2021 | Genes & Diseases2021，8，3： | 4 |
| 17 | Numerical Approach for Atmospheric Corrosion Monitoring Based on EIS of a Weathering Steel显示文摘Electrochemical impedance spectroscopy(EIS) and film thickness measurement have been employed to study the atmospheric corrosion of a weathering steel covered with a thin electrolyte layer in a simulated coastal–industrial atmosphere. The results indicate that the corrosion rate is a function of the covered electrolyte thickness and the wet/dry cycle. Within each wet/dry cycle, the increased corrosion rate is related to the increased Cl-and SO2-4concentration and an enhancement of oxygen diffusion rate with the evaporation of the electrolyte. In addition, the corrosion rate increases during the initial corrosion stage and then decreases as the wet/dry cycle proceeds. Moreover, one mathematical approach based on the numerical integration method to obtain corrosion mass loss of steel from the measurements of EIS has been developed, and this would be useful for the development of indoor simulated atmospheric corrosion tests. | Ch.Thee Long Hao Jun-Hua Dong Xin Mu Wei Ke | 2015 | Acta Metallurgica Sinica(English Letters)2015，28，2： | 4 |
| 18 | Acetate-assistant efficient cation-exchange of halide perovskite nanocrystals to boost the photocatalytic CO_(2) reduction显示文摘The judicious implantation of active metal cations into the surface of semiconductor nanocrystal(NC)through cation-exchange is one of the facile and viable strategies to enhance the activity of catalysts for photocatalytic CO_(2)reduction,by shortening the transfer pathway of photogenerated carriers and increasing the active sites simultaneously.However,cation-exchange is hard to achieve for halide perovskite NCs owing to the stable octahedron of[PbX6]4−with strong interaction between halogen and lead.Herein,we report a facile method to overcome this obstacle by replacing partial Br−with acetate(Ac−)to generate CsPbBr_(3) NC(coded as CsPbBr_(3−x)Ac_(x)).A small amount of Ac−instead of Br−does not change the crystal structure of halide perovskite.Owing to the weaker interaction between acetate and lead in comparison with bromide,the corresponding octahedron structure containing acetate in CsPbBr_(3−x)Ac_(x) can be easily opened to realize efficient cation-exchange with Ni^(2+) ions.The resulting high loading amount of Ni^(2+) as active site endows CsPbBr_(3−x)Ac_(x) with an improved performance for photocatalytic CO_(2)reduction under visible light irradiation,exhibiting a significantly increased CO yield of 44.09μmol·g^(−1)·h^(−1),which is over 8 and 3 times higher than those of traditional pristine CsPbBr_(3) and nickel doped CsPbBr_(3) NC,respectively.This work provides a critical solution for the efficient metal doping of low-cost halide perovskite NCs to enhance their photocatalytic activity,promoting their practical applications in the field of photocatalysis. | Jialin Cheng Yanfei Mu Liyuan Wu Zhaolei Liu Ke Su Guangxing Dong Min Zhang Tongbu Lu | 2022 | Nano Research2022，15，3： | 3 |
| 19 | Corrosion kinetics and patina evolution of galvanized steel in a simulated coastal-industrial atmosphere显示文摘The corrosion kinetics and patina(corrosion products) layer evolution of galvanized steel submitted to wet/dry cyclic corrosion test in a simulated coastal-industrial atmosphere was investigated. The results show that zinc coating has a greater corrosion rate during the initial period and a lower corrosion rate during the subsequent period, and the patina composition and structure can greatly affect the corrosion kinetics evolution of zinc coating. Moreover, Zn5(OH)6(CO3)2 and Zn4(OH)6 SO4 are identified as the main stable composition and exhibit an increasing relative amount;while Zn12(OH)15Cl3(SO4)3 cannot stably exist and diminish in the patina layer as the corrosion develops. | Chuang Qiao Lianfeng Shen Long Hao Xin Mu Junhua Dong Wei Ke Jing Liu Bo Liu | 2019 | Journal of Materials Science & Technology2019，35，10： | 3 |
| 20 | mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines显示文摘Although IL-12 plays a critical role in priming Th1 and cytotoxic T lymphocyte(CTL) responses, Toll-like receptor(TLR) signaling only induces low amounts of IL-12 in dendritic cells and macrophages, implying the existence of stringent regulatory mechanisms. In this study, we sought to uncover the mechanisms underlying TLR-induced IL-12 expression and the Th1 response. By systemic screening, we identified a number of protein kinases involved in the regulation of TLRinduced IL-12 expression. In particular, PI3 K, ERK, and m TOR play critical roles in the TLR-induced Th1 response by regulating IL-12 and IL-10 production in innate immune cells. Moreover, we identified c-fos as a key molecule that mediates m TOR-regulated IL-12 and IL-10 expression in TLR signaling. Mechanistically, m TOR plays a crucial role in c-fos expression, thereby modulating NFκB binding to promoters of IL-12 and IL-10. By controlling the expression of a special innate gene program, m TOR can specifically regulate the TLR-induced T cell response in vivo. Furthermore, blockade of m TOR by rapamycin efficiently boosted TLR-induced antigen-specific T and B cell responses to HBV and HCV vaccines. Taken together, these results reveal a novel mechanism through which m TOR regulates TLR-induced IL-12 and IL-10 production, contributing new insights for strategies to improve vaccine efficacy. | Li He Aiping Zang Min Du Dapeng Ma Chuanping Yuan Chun Zhou Jing Mu Huanjing Shi Dapeng Li Xulin Huang Qiang Deng Jianhua Xiao Huimin Yan Lijian Hui Ke Lan Sidong Xiong Xiaoxia Li Zhong Huang Hui Xiao | 2015 | Virologica Sinica2015，30，3： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员