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91篇 您的检索式:作者名="Mouse"
    题名 作者 年代 出处 被引量
1Differential Effect of Artemisinin Against Cancer Cell Lines显示文摘The present study aims at defining the differential cytotoxicity effect of artemisinin toward P815(murin mastocytoma)and BSR(kidney adenocarcinoma of hamster)cell lines.Cytotoxicity was measured by the growth inhibition using MTT assay.These in vitro cytotoxicity studies were complemented by the determination of apoptotic DNA fragmentation and Annexin V-streptavidin-FITC assay.Furthermore,we examined the in vitro synergism between artemisinin and the chemotherapeutic drug,vincristin.The in vivo study was investigated using the DBA2/P815(H2d)mouse model.While artemisinin acted on both tumor cell lines,P815 was much more sensitive to this drug than BSR cells,as revealed by the respective IC50 values(12 lM for P815 and 52 lM for BSR cells).On another hand,and interestingly,apoptosis was induced in P815 but not induced in BSR.These data,reveal an interesting differential cytotoxic effect,suggesting the existence of different molecular interactions between artemisinin and the studied cell lines.In vivo,our results clearly showed that the oral administration of artemisinin inhibited solid tumor development.Our study demonstrates that artemisinin caused differential cytotoxic effects depending not only on the concentration and time of exposure but also on the target cells.Mounir Tilaoui Hassan Ait Mouse Abdeslam Jaafari Abdelmajid Zyad 2014Natural Products and Bioprospecting2014,4,3:8
2The Secl4 superfamily and mechanism for crosstalk between lipid metabolism and lipid signaling显示文摘Bankaitis V A Mousely C J Schaaf G 0,,03:1
3Expression ofmanganese superoxide dismutase promoted cellular differentia-tion显示文摘DARE K S C OBERLEY T D MOUSE K E 1994Free Radical Biology & Medicine1994,16,:1
4Initial sequencing and comparative analysis of the mouse genome显示文摘Mouse Genome Sequencing Consortium Waterston R H Lindblad- Toh K 2002Nature2002,420,6915:1
5Apptication of mesenchyrmal stem cells to liver regenerative medicine显示文摘marrow cells restore mouse liver Yagi K Kojima M Oyagi 8 2012Yakugaku Zasshi2012,128,1:1
6Generation of a hu- human immune system and liver cells to model hepatitis C virus infection and liver immunopatho- genesis 显示文摘Bility MT Zhang L Washburn manized mouse model with both ML etal 2012NatProtoc2012,7,9:1
7Risk assessment folloe- ing the hypothetical import of dioxin-contaminated feed for pigs -4- an example of quantitative decision-support under emergency conditions显示文摘Katharina D C Boyd H B Mousing J 2002Food Control2002,,13:1
8Stresses in Cylindrical Tanks Due to Uneven Circumferential Settlement 显示文摘Mouse E A Ruiz C 1979Journal of Strain Analysis1979,15,1:1
9Removing the light history signal from normalized variable fluorescence (Fv/Fm) measurements on marine phytoplankton显示文摘From N Richardson K Mousing E A 2014Limnology and Oceanography: Methods2014,12,11:1
10Bacterial load in relation to vacuum-assisted closure wound therapy:a prospective randomized trial显示文摘Mouse CM Vos MC Van den Bemd GJ 2004Wound Repair Regen2004,12,1:1
11Initial sequencing and comparative analysis of the mouse genome 显示文摘Mouse Genome Sequencing Consortium 2002Nature2002,420,6915:1
12Microwave vacuum drying of banana slices显示文摘Mouse N Farid M 2002Drying Technology2002,22,10:1
13Initial sequencing and comparative analysis of the mouse genome显示文摘Mouse Genome Sequencing Consortium 0,,6915:1
14A Peripheral Site-occluding Loop in a Tetra- meric Assembly 显示文摘Bourne Y Taylor P Bougis P E Crystal Structure of Mouse Acetylcholinesterase 1999Journal of Biological Chemistry1999,274,5:1
15Initial sequencing and comparative analysis of themouse genome 显示文摘Mouse Genome Sequencing Consortium Waterston RH Lindblad-Toh K 2002Nature2002,420,6915:1
16显示文摘Jerez-Timaure NC Eisen EJ Pomp D Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2 2005Physiol Genomics2005,21,3:1
17Comparison of computed tomographic angiography with digitalsubtraction angiography is the diagnosis of cerebral aneurysms : a meta-analysis显示文摘ChappeU ET Mouse FC Good MC 2003Neurosurgy2003,52,:1
18Initial seouencing and comparative analysis of mouse genome显示文摘Mouse genome sequencing consortium 2002Nature2002,460,:1
19Perineurial defect and periph- eral opioid analgesia in inflammation 显示文摘Antonijevic I Mouse SA Schafer M 1995J neurosci1995,15,11:1
20the conversion of tuberculosis infeetion to the latent state by the administration of pyrazinamide and a companion drug 显示文摘Mccune RMJr McDermott W Tompsett R The fate of Mycohacterium tuberculosis in mouse tissues as determined by the microbid enumeration technique Ⅱ 1956J Exp med1956,104,5:1
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