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149篇 您的检索式:作者名="Mou Peng"
    题名 作者 年代 出处 被引量
1Diagnostic value of cancer-testis antigen mRNA in peripheral blood from hepatocellular carcinoma patients显示文摘AIM:To evaluate the diagnostic value of cancer-testis antigen(CTA) mRNA in peripheral blood samples from hepatocellular carcinoma(HCC) patients.METHODS:Peripheral blood samples were taken from 90 patients with HCC before operation.Expression of melanoma antigen-1(MAGE-1),synovial sarcoma X breakpoint-1(SSX-1),and cancer-testis-associated protein of 11 kDa(CTp11) mRNA in peripheral blood mononuclear cells(PBMC) was tested by nested reverse transcriptspolymerase chain reaction(RT-PCR).Serum α-fetoprotein(AFP) in these patients was also determined.RESULTS:The positive rate of MAGE-1,SSX-1 and CTp11 transcripts was 37.7%,34.4%,31.1% in PBMC samples,and 74.4%,73.3%,62.2% in their resected tumor samples,respectively.The positive rate for at least one of the transcripts of three CTA genes was 66.7% in PBMC samples and 91.1% in their resected tumor samples.MAGE-1,SSX-1 and/or CTp11 mRNA were not detected in the PBMC of those patients from whom the resected tumor samples were MAGE-1,SSX-1 and/or CTp11 mRNA negative,nor in the PBMC samples from 20 healthy donors and 10 cirrhotic patients.Among the 90 patients,the serum AFP in 44 patients met the general diagnostic standard(AFP > 400 μg/L) for HCC,and was negative(AFP ≤ 20 μg/L) or positive with a low concentration(20 μg/L < AFP ≤ 400 μg/L) in the other patients.The positive rate for at least one of the transcripts of three CTA genes in PBMC samples from the AFP negative or positive patients with a low concentration was 69.2% and 45.0%,respectively.Of the 90 patients,71(78.9%) were diagnosed as HCC by nested RT-PCR and serum AFP.Although the positive rate for at least one of the transcripts of three CTA genes in PBMC samples from 53 patients at TNM stage or was obviously higher than that in PBMC samples from 37 patients at stage or(77.9% vs 51.4%,P = 0.010),the CTA mRNA was detected in 41.7% and 56.0% of PBMC samples from HCC patients at stages andrespectively.CONCLUSION:Detecting MAGE-1,SSX-1 and CTp11 mRNA in PBMC improves the total diagnostic rate of HCC.Li Zhao Dong-Cheng Mou Zeng-An Wu Ji-Run Peng Lei Huang Xi-Sheng Leng 2010World Journal of Gastroenterology2010,16,32:22
2Promotive Effects of Alginate-Derived Oligosaccharides on the Inducing Drought Resistance of Tomato显示文摘In order to determine the role of alginate-derived oligosaccharides (ADO) in drought stress resistance of tomato (Ly-copersicon esculentum Miller) seedlings, the leaves were exposed to different concentrations of ADO (0.05%, 0.10%, 0.20%, 0.30% and 0.50%) after drought stress was simulated by exposing the roots to 0.6 molL-1 PEG-6000 solution for 6 h. Changes in biomass, electrolyte leakage and malondialdehyde (MDA), free proline, total soluble sugars (TSS) and abscisic acid (ABA), the enzyme activities of catalase (CAT), superoxide dismutase (SOD), peroxidase (POD) and phenylalanine ammonia-lyase (PAL) were measured to investigate the effects of ADO treatment. The results showed that the treatment with an ADO concentration of 0.20% exhibited the highest performance of drought stress resistance in the tomato seedlings by decreasing the electrolyte leakage and the concentration of MDA, increasing the contents of free proline, TSS and ABA, and increasing the activities of CAT, SOD, POD and PAL after treatment with ADO. It is suggested that changes in electrolyte leakage, MDA, osmotic solutes, ABA, anti-oxidative enzyme and PAL activities were responsible for the increased drought stress resistance in tomato seedlings. To our best knowledge, this is the first report of the effect of ADO treatment on enhancing the drought stress resistance of tomato seedlings.LIU Ruizhi JIANG Xiaolu GUAN Huashi LI Xiaoxia DU Yishuai WANG Peng MOU Haijin 2009Journal of Ocean University of China2009,8,3:16
3The PCA3 test for guiding repeat biopsy of prostate cancer and its cut-off score: a systematic review and meta-analysis显示文摘为在重复活体检视的早干预的前列腺特定的抗原(PSA ) 的特性是不能令人满意的。(PCA3 ) 前列腺癌症抗原 3 可能比为前列腺癌症(PCa ) 的早察觉的另外的方法在结果预言是更精确的。然而,结果在重复活体检视是不一致的。因此,我们执行了系统的评论和元分析在结果预言评估 PCA3 的角色。系统的文献的搜索为在 2013 年 4 月前出版的文章被进行,用从健康技术评价机构的 PubMed, Medline,科学的网, Embase 和另外的数据库。研究的质量根据 QUADAS 标准被估计。诊断测试与的十一研究对高质量中等被选择。元分析被执行综合结果。元分析的结果在研究之中是异构的。我们执行了亚群分析(与或没有高级 prostatic intraepithelial 瘤形成(HGPIN ) 和不正常的小 acinar 增长的包括(尽快)) 。用 20 或 35 的 PCA3 截止,在二亚群,全球敏感价值是 0.93 或 0.80 和 0.79 或 0.75 ,特性是 0.65 或 0.44 和 0.78 或 0.70 ,积极可能性的比率是 1.86 或 1.58 和 2.49 或 1.78 ,否定可能性的比率是 0.81 或 0.43 和 0.91 或 0.82 ,诊断奇怪的比率( ORs )分别地是 5.73 或 3.45 和 7.13 或 4.11 。在操作典型曲线的概括接收装置的曲线(AUC ) 下面的区域分别地是 0.85 或 0.72 和 0.81 或 0.69。PCA3 能被用于前列腺的重复活体检视改进 PCa 察觉的精确性。不必要的活体检视能被使用 20 的一个 PCa 截止分数避免。Yong Luo Xin Gou Peng Huang Chan Mou 2014Asian Journal of Andrology2014,16,3:13
4Codon 249 mutations of p53 gene in non-neoplastic liver tissues显示文摘Subjectheadingsliver;p53gene;codon249mutation;liverneoplasms;hepatitis,viral;livercirhosis;polymerasechainreactionAbstractAIM...PENG Xiao Mou, YAO Chun Lan, CHEN Xue Juan, PENG Wen Wei and GAO Zhi Liang 1999World Journal of Gastroenterology1999,5,4:12
5Personalized treatment based on mini patient-derived xenografts and WES/RNA sequencing in a patient with metastatic duodenal adenocarcinoma显示文摘Background:Treatment guidelines for a variety of cancers have been increasingly used in clinical practice,and have resulted in major improvement in patient outcomes.However,recommended regimens(even first-line treat-ments)are clearly not ideal for every patients.In the present study,we used mini patient-derived xenograft(mini-PDX)and next-generation sequencing to develop personalized treatment in a patient with metastatic duodenal adenocarcinoma.Methods:Resected metachronous metastatic tumor tissues were implanted into SCID mice to determine the sensitivity to a variety of drug regimens.Mutation profiles were assessed using both DNA whole-exome sequencing(DNA-WES)and RNA sequencing.The results of the analyses were used to select optimal treatment for the patient with metastatic duodenal adenocarcinoma.Results:Assessment with mini-PDX models took only 7 days.The results showed high sensitivity to S-1 plus cis-platin,gemcitabine plus cisplatin and everolimus alone.The patient received gemcitabine plus cisplatin initially,but the treatment was terminated due to toxicity.The patient was then switched to treatment with S-1 alone.The overall disease-free survival was 34 months.DNA-WES and RNA sequencing identified KRAS mutation(A146T),TP53(C229Yfs*10)and RICTOR amplification in the metastatic duodenal adenocarcinoma.These findings provided further support to the results of the mini-PDX,and suggest mTOR inhibitors should be used if and when relapse eventually occurs in this patient.Conclusions:Mini-PDX model combined with WES/RNA sequencing can rapidly assess drug sensitivity in cancer patients and reveal key genetic alterations.Further research on this technology for personalized therapy in patients with refractory malignant tumors is warranted.Peng Zhao Hui Chen Danyi Wen Shuo Mou Feifei Zhang Shusen Zheng 2018Cancer Communications2018,38,1:11
6Application effect for a care bundle in optimizing nursing of patients with severe craniocerebral injury显示文摘BACKGROUND Severe craniocerebral injury(STBI)is a critical physical trauma caused by a sudden external force acting on the head.The condition is complex and changeable,and disability and mortality rates are high.Although the life of STBI patients can be saved through treatment,the sequelae of consciousness,speech,cognitive impairment,stiffness,spasm,pain and abnormal behavior in the early rehabilitation stage can be a heavy burden to a family.In the past,routine nursing was often used to treat/manage STBI;however,problems,such as improper cooperation and untimely communication,reduced therapeutic effectiveness.AIM To investigate the effect of a proposed care bundle to optimize the first aid process and assess its effectiveness on the early rehabilitation nursing of patients with STBI.METHODS From January 2019 to December 2020,126 STBI patients were admitted to the emergency department of Chongqing Emergency Medical Center.These patients were retrospectively selected as the research participants in the current study.The study participants were then divided into a control group(61 cases)and a study group(65 cases).The control group was treated with routine nursing.The study group adopted the proposed care bundle.The National Institutes of Health Stroke Scale/Score and Glasgow Coma Scale(GCS)were used to evaluate neurological function before and after emergency treatment.After 3 mo of rehabilitation,experimental outcomes were assessed.These included the GCS,Barthel Index,complication rate,muscle strength grade and satisfaction.RESULTS There was no significant difference in gender,age,cause of injury and GCS between the two groups.After emergency,the National Institutes of Health Stroke Scale/Score of the study group(10.23±3.26)was lower than that of the control group(14.79±3.14).The GCS score of the study group(12.48±2.38)was higher than that of the control group(9.32±2.01).The arrival time of consultation in the study group was 20.56±19.12,and the retention time in the emergency room was 45.12±10.21,which were significantly shorter than those in the control group.After 3 mo of rehabilitation management,the GCS and Barthel Index of the study group were 14.56±3.75 and 58.14±12.14,respectively,which were significantly higher than those of the control group.The incidence of complications in the study group(15.38%)was significantly lower than that in the control group(32.79%).The proportion of muscle strength≥grade III in the study group(89.23%)was significantly higher than that in the control group(50.82%).The satisfaction of patients in the study group was significantly higher than that in the control group.CONCLUSION Care bundles are used to optimize the nursing process.During first-aid,care bundles can effectively improve the rescue effect and improve neurological function of STBI patients as well as shorten the treatment time.In early rehabilitation,they can effectively improve the consciousness of STBI patients,improve the activities of daily living,reduce the risk of complications,accelerate the recovery of muscle strength and improve their satisfaction.Ying Gao Li-Ping Liao Peng Chen Ke Wang Cui Huang Ying Chen Shao-Yu Mou 2021World Journal of Clinical Cases2021,9,36:10
7GW5-Like, a homolog of GW5, negatively regulates grain width, weight and salt resistance in rice显示文摘Grain size is an important determinant of yield potential in crops. We previously demonstrated that natural mutations in the regulatory sequences of qSW5/GW5 confer grain width diversity in rice. However, the biological function of a GW5 homolog, named GW5-Like(GW5 L), remains unknown. In this study, we report on GW5 L knockout mutants in Kitaake, a japonica cultivar(cv.)considered to have a weak gw5 variant allele that confers shorter and wider grains. GW5 L is evenly expressed in various tissues, and its protein product is localized to the plasma membrane. Biochemical assays verified that GW5 L functions in a similar fashion to GW5. It positively regulates brassinosteroid(BR) signaling through repression of the phosphorylation activity of GSK2. Genetic data show that GW5 L overexpression in either Kitaake or a GW5 knockout line, Kasaorf3(indica cv. Kasalath background), causes more slender, longer grains relative to the wild-type. We also show that GW5 L could confer salt stress resistance through an association with calmodulin protein OsCa M1-1. These findings identify GW5 L as a negative regulator of both grain size and salt stress tolerance, and provide a potential target for breeders to improve grain yield and salt stress resistance in rice.Peng Tian Jiafan Liu Changling Mou Cuilan Shi Huan Zhang Zhichao Zhao Qibing Lin Jie Wang Jiulin Wang Xin Zhang Xiuping Guo Zhijun Cheng Shanshan Zhu Yulong Ren Cailin Lei Haiyang Wang Jianmin Wan 2019Journal of Integrative Plant Biology2019,61,11:9
8Effects of 5-hydroxytamine and its antagonists on hepatic stellate cells显示文摘BACKGROUND: Hepatic stellate cell (HSC) plays a key role in hepatic fibrosis. This study was undertaken to investigate the expression of 5-hydroxytamine receptors in HSC and the effect of 5-hydroxytamine on biological characteristics of HSC. METHODS: Liver ex vivo perfusion of collagenase and density gradient centrifugation were used to isolate HSCs. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the expression of 5-hydroxytamine receptor subtypes 1A, 2A, 2B and 3. Western blot hybridization was used to elucidate the effect of 5-hydroxytamine and its 2A receptor antagonist ketanserin and 3 receptor antagonist ondanosetron on the expression of transforming growth factor-β1(TGF-β1) and Smad4 in HSC. RESULTS: HSC expressed 5-hydroxytamine receptor subtypes 1A, 2A and 2B. 5-hydroxytamine significantly increased the expression of TGF-β1, and Smad4 in HSC (P<0.05). This action can be antagonized by ketanserin, not by ondanosetron. CONCLUSIONS: HSC expresses 5-hydroxytamine receptors. 5-hydroxytamine could effect the biological characteristics of HSC through its receptor mediation, and may play a role in the pathogenesis of liver cirrhosis and portal hypertension.Tao Li, Shan-Geng Weng, Xi-Sheng Leng, Ji-Run Peng, Yu-Hua Wei, Dong-Cheng Mou and Wan-Xiang Wang Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing 100044, China 2006Hepatobiliary & Pancreatic Diseases International2006,5,1:7
9Surface modification of polyolefin separators for lithium ion batteries to reduce thermal shrinkage without thickness increase显示文摘Surface chemical modification of polyolefin separators for lithium ion batteries is attempted to reduce the thermal shrinkage, which is important for the battery energy density. In this study, we grafted organic/inorganic hybrid crosslinked networks on the separators, simply by grafting polymerization and condensation reaction. The considerable silicon-oxygen crosslinked heat-resistance networks are responsible for the reduced thermal shrinkage. The strong chemical bonds between networks and separators promise enough mechanical support even at high temperature. The shrinkage at 150 C for 30 min in the mechanical direction was 38.6% and 4.6% for the pristine and present graft-modified separators, respectively. Meanwhile, the grafting organic-inorganic hybrid crosslink networks mainly occupied part of void in the internal pores of the separators, so the thicknesses of the graft-modified separators were similar with the pristine one. The half cells prepared with the modified separators exhibited almost identical electrochemical properties to those with the commercial separators, thus proving that, in order to enhance the thermal stability of lithium ion battery, this kind of grafting-modified separators may be a better alternative to conventional silica nanoparticle layers-coated polyolefin separators.Peng Zhao Juping Yang Yuming Shang Li Wang Mou Fang Jianlong Wang Xiangming He 2015Journal of Energy Chemistry2015,24,2:3
10High Initial Reversible Capacity and Long Life of Ternary SnO_(2)-Co-carbon Nanocomposite Anodes for Lithium-Ion Batteries显示文摘The two major limitations in the application of SnO_2 for lithium?ion battery(LIB) anodes are the large volume variations of SnO_2 during repeated lithiation/delithiation processes and a large irreversible capacity loss during the first cycle, which can lead to a rapid capacity fade and unsatisfactory initial Coulombic e ciency(ICE). To overcome these limitations, we developed composites of ultrafine SnO_2 nanoparticles and in situ formed Co(CoSn) nanocrystals embedded in an N?doped carbon matrix using a Co?based metal–organic framework(ZIF?67). The formed Co additives and structural advantages of the carbon?confined SnO_2/Co nanocomposite e ectively inhibited Sn coarsening in the lithiated SnO_2 and mitigated its structural degradation while facilitating fast electronic transport and facile ionic di usion. As a result, the electrodes demonstrated high ICE (82.2%), outstanding rate capability(~ 800 mAh g^(-1) at a high current density of 5 A g^(-1)), and long?term cycling stability(~ 760 mAh g^(-1) after 400 cycles at a current density of 0.5 A g^(-1)). This study will be helpful in developing high?performance Si(Sn)?based oxide, Sn/Sb?based sulfide, or selenide electrodes for LIBs. In addition, some metal organic frameworks similar to ZIF?67 can also be used as composite templates.Pan Deng Jing Yang Shengyang Li Tian-E Fan Hong-Hui Wu Yun Mou Hui Huang Qiaobao Zhang Dong-Liang Peng Baihua Qu 2019Nano-Micro Letters2019,11,1:2
11Prostate cancer antigen 3 test for prostate biopsy decision: a systematic review and meta analysis显示文摘Luo Yong Gou Xin Huang Peng Mou Chan 2014Chinese Medical Journal2014,,9:2
12A Study of Soil-dynamics Based on a Simulated Drought in an Alpine Meadow on the Tibetan Plateau显示文摘Extreme weather events have played an important role in driving the ecosystem dynamics in high altitude areas,but the underlying mechanism remains unclear.To understand if and how the soil processes of an ecosystem react to extreme drought,we manipulated a once-in-a-century meteorological extreme drought in an alpine meadow on the Tibetan Plateau,which is also known as the 'forerunner of global weather changes'.The extremity was determined by statistical extreme weather events with respect to a historical reference period from April to September during 1962-2004,where the local historical precipitation data was calculated and intensified to 100-year recurrent drought event with GumbelⅠdistribution.The indicators we measured included soil microbial biomass C/N/P and soil enzymatic activities of phosphatase(AP) disbounding organic phosphate,cellobiohydrolase(CBH),βglucocidase(BG),N-releasing enzyme N-acetylglucosaminidase(NAG) as well as soil respirations,during and after the treatments.It was found that the manipulated event induced a rapid shift in microbial biomass and activities,indicating a lower resistance of the underground process.However,the microbial and biochemical parameters saw rapid recovery after the event,which meant the soil processes enjoyed high resilience.The high responsiveness and lag-time effects of the soil indicators rendered new horizons for us to evaluate the interaction between the extremes and the ecosystem stability.Our study indicated that the once-in-a-century extreme drought induced very short term response in the soil biotic process,and the soil processes worked to buffer against such events under the observation period.WANG Zhi-yuan SUN Geng LUO Peng MOU Cheng-xiang WANG Jun 2013Journal of Mountain Science2013,10,5:2
13Binding pancreaticojejunostomy: 150 consecutive cases without leakage显示文摘Shu You Peng M.D. Yi Ping Mou M.D. Yin Bin Liu M.D. Ying Su M.D. Cheng Hong Peng M.D. Xiu Jun Cai M.D. Yu Lian Wu M.D. Lin Hua Zhou M.D 2003Journal of Gastrointestinal Surgery2003,,7:2
14Progression rate to primary angle closure following laser peripheral iridotomy in primary angle-closure suspects: a randomised study显示文摘AIM:To report the progression rate(PR)to primary angle closure(PAC)following laser peripheral iridotomy(LPI)in PAC suspects(PACS).METHODS:Prospective,randomized controlled interventional clinical trial conducted at the Handan Eye Hospital,China.Totally 134 bilateral PACS,defined as non-visibility of the posterior trabecular meshwork for≥180 degrees on gonioscopy were randomly assigned to undergo LPI in one eye.Gonioscopy and Goldmann applanation tonometry were performed prior to,on day 7 and 12 mo post LPI.RESULTS:Eighty of 134 patients(59.7%)could be followed up at one year.The mean intraocular pressure(IOP)in treated eyes was 15.9±2.6 mm Hg at baseline,15.4±3.0 mm Hg on day 7;16.5±2.9 mm Hg at one month,and 15.5±2.9 mm Hg at 12 mo;the IOP in untreated eyes was similar(P=0.834).One or more quadrants of the angle opened in 93.7%of the LPI treated eyes,but 67.0%(53/79)remained closed in two or more quadrants.The PR to PAC in untreated eyes was 3.75%and one developed acute angleclosure glaucoma(AACG);the PR to PAC in treated eyes was 2.5%and none had developed peripheral anterior synechia(PAS)or AACG.CONCLUSION:LPI can open some of the occludable angle in the majority of eyes with PACS,but 67%continue to have non-visibility of the trabecular meshwork for over 180 degrees.Da-Peng Mou Yuan-Bo Liang Su-Jie Fan Yi Peng Ning-Li Wang Ravi Thomas 2021International Journal of Ophthalmology(English edition)2021,14,8:2
15Synthesis and evaluation of 2-cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide as a potent anti-inflammatory agent for intervention of LPS-induced acute lung injury显示文摘The present study was designed to synthesize 2-Cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide(1), a lactone derivative of oleanolic acid(OA) and evaluate its anti-inflammatory activity. Compound 1 significantly diminished nitric oxide(NO) production and down-regulated the m RNA expression of iNOS, COX-2, IL-6, IL-1β, and TNF-α in lipopolysaccharide(LPS)-stimulated RAW264.7 cells. Further in vivo studies in murine model of LPS-induced acute lung injury(ALI) showed that 1 possessed more potent protective effects than the well-known anti-inflammatory drug dexamethasone by inhibiting myeloperoxidase(MPO) activity, reducing total cells and neutrophils, and suppressing inflammatory cytokines expression, and thus ameliorating the histopathological conditions of the injured lung tissue. In conclusion, compound 1 could be developed as a promising anti-inflammatory agent for intervention of LPS-induced ALI.MOU Yi JIAN Yan-Lin CHEN Tong HUANG Zhang-Jian QIAO Yi-Xue PENG Si-Xun ZHANG Da-Yong JI Hui ZHANG Yi-Hua 2017Chinese Journal of Natural Medicines2017,15,5:2
16Unique sandwich design of high-efficiency heat-conducting phosphor-in-glass film for high-quality laser-driven white lighting显示文摘Multi-color phosphor-in-glass(PiG)film has been considered as a promising color converter in high-quality laser lighting owing to its outstanding merits of phosphor versatility,tunable luminescence,and simple preparation.However,the opto-thermal properties of PiG film are severely affected by the photon reabsorption and backward scattering of phosphor structure and the heat conduction of substrate.Herein,a unique sandwich design of phosphor structure was introduced in the multi-color PiG film for high-quality laser lighting.By elaborately synthesizing the borosilicate glass with low glass transition temperature(T_(g)),similar expansion coefficient,and high refractive index(RI),the sandwiched PiGs were prepared by sintering(~600℃)broadband green and red phosphor glass films on the double sides of sapphire.The green and red PiG films were tightly coated on the sapphire with no delamination and maintained higher luminescence intensity than raw phosphors at high temperatures.By simultaneously coupling photon reabsorption and backward scattering,the sandwiched green PiG film-sapphire-red PiG film(G-S-R PiG)yields a high-quality white light with a high luminous efficacy of 163 lm/W and an excellent color rendering index(CRI)of 85.4 under a laser power of 2.4 W,which are the best comprehensive results yet reported.Benefiting from the ingenious sandwich design with heat-conducting sapphire and thin PiG films,the G-S-R PiG displays low working temperatures(<200℃)under high-power laser excitation.This work reveals the role of sandwiched phosphor structure in photon loss and heat dissipation,which provides a new strategy to design PiG films for high-quality laser lighting.Yang PENG Zikang YU Jiuzhou ZHAO Qing WANG Jiaxin LIU Bo SUN Yun MOU Mingxiang CHEN 2022Journal of Advanced Ceramics2022,11,12:2
17Binding pancreaticojejunostomy is a new technique to minimize leakage显示文摘Peng S Mou Y Cai X 2002Am J Surg2002,183,:1
18Binding pancreaticojejunostomy: 150 consecutive cases without leakage 显示文摘Peng SY Mou YP Liu YB 2003J Gastrointest Surg2003,7,7:1
19Evaluation of MAGE-1 and MAGE-3 as tumor-specific markers to detect blood dissemination of hepatocellular carcinoma cells显示文摘Mou DC Cai SL Peng JR 2002Br J Cancer2002,86,1:1
20Binding pancreaticojejunostomy is a new technique to minimize leakage显示文摘Peng S Y Mou Y Cai X 2002Am J Surg2002,183,3:1
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