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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | Surgical treatment of displaced intra-articular catcaneal fracture using a single small lateral approach 显示文摘 | Mostafa M F E1-Adi G Hassanin E Y | 2010 | Strategies Trauma Limb Reconstr2010，5，2： | 1 |
| 3 | Investigations on the pertormance of centrifugal pumps in conjunction with inducers 显示文摘 | SAMANODY M A E GHORAB A MOSTAFA M A F | 2013 | Ain shams engineering journal2013，5，1： | 1 |
| 4 | An interior point constrained trust region method for a special nonlinear semidefinite programming problems 显示文摘 | LEIBFRITZ F MOSTAFA E M E | 2002 | SIAM Journal on Optimization2002，12，4： | 1 |
| 5 | A novel control algorithm for the DG interface to mitigate power quality problems显示文摘 | Marei Mostafa I EI-Saadany Ehab F Salama Magdy M A | 2004 | IEEE Trans on Power Delivery2004，19，3： | 1 |
| 6 | Insitustable isotopic evi- dence for protracted and complex carbonate cementation in a petroleum reservoir, North Coles Levee, San Joaquin basin, California, USA 显示文摘 | Mostafa F Harrison T M Grove M | 2001 | J Sediment Res2001，71，3： | 1 |
| 7 | Characterization of certain steroid hormones in Punica grarmtum L seeds 显示文摘 | Abd El Wahab S M Fiki N M EI Mostafa S F | 1998 | Bull Fac Phama Cario Univ1998，36，1： | 1 |
| 8 | Contact angles and the equilibrium spreading pressures of liquids on hydrophobic solids显示文摘 | Fowkes F M McCarthy D C Mostafa M A | 1980 | Journal of Colloid and Interface Science1980，78，1： | 1 |
| 9 | In vitro activity of quinupristin/dalfopristin RP59500, against gram-positive clinical isolates显示文摘 | Qadri S M Ueno Y Abu Mostafa F M | 1997 | Chemotherapy1997，43，： | 1 |
| 10 | Effects of Hydrogen Cyanamide 'Dormex' on budbreak, vegetative growth and fruiting of 'White Banaty' and 'Roomy Red' grapevines under Assiut conditions显示文摘 | Kassas E L Sese A M A Mostafa F M A | 1998 | Assiut Journal of Agricultural Sciences1998，29，3： | 1 |
| 11 | In situ stable isotopic evidence for protracted and complex carbonate cementation in a petroleum reservoir, North Coles Levee, San Joaquin basin, California, USA显示文摘 | Mostafa F Harrison T M Grove M | 2001 | Journal of Sedimentary Research2001，71，3： | 1 |
| 12 | Folded novel accurate analytical and semi-analytical solutions of a generalized Calogero–Bogoyavlenskii–Schiff equation显示文摘This paper studies the analytical and semi-analytic solutions of the generalized Calogero–Bogoyavlenskii–Schiff(CBS)equation.This model describes the(2+1)–dimensional interaction between Riemann-wave propagation along the y-axis and the x-axis wave.The extended simplest equation(ESE)method is applied to the model,and a variety of novel solitarywave solutions is given.These solitary-wave solutions prove the dynamic behavior of soliton waves in plasma.The accuracy of the obtained solution is verified using a variational iteration(VI)semi-analytical scheme.The analysis and the match between the constructed analytical solution and the semi-analytical solution are sketched using various diagrams to show the accuracy of the solution we obtained.The adopted scheme’s performance shows the effectiveness of the method and its ability to be applied to various nonlinear evolution equations. | Mostafa M A Khater S K Elagan M A El-Shorbagy S H Alfalqi J F Alzaidi Nawal A Alshehri | 2021 | Communications in Theoretical Physics2021，73，9： | 1 |
| 13 | Charac- terization and phenols sorptive properties of carbons activated by sulphuric acid显示文摘 | MOHAMED F S KHATER W A MOSTAFA M R | 2006 | Chemical Engineering Journal2006，116，1： | 1 |
| 14 | An experiment investigatlon on the W-Cu composites显示文摘 | Ibrahim A Abdallah M Mostafa S F | 2009 | Material and Design2009，30，4： | 1 |
| 15 | Characterization of certain steroid hormones in Punica grarrntum L seeds显示文摘 | Abd EI Wahab S M Fiki N M EI Mostafa S F etal | 1998 | Bull Fac Phama Cario Univ1998，36，1： | 1 |
| 16 | In situ stable isotopic evidence for protracted and complex carbonate cementation in a petroleum reservoir, North Coles Levee, San Joaquin basin, California, USA显示文摘 | MOSTAFA F HARRISON T M GROVE M | 2001 | Journal of Sedimentary Research2001，71，3： | 1 |
| 17 | In situ stable isotopic evidence for protracted and complex carbonate cementation in a petroleum reservoir,North Coles Levee,San Joaquin basin,California,USA显示文摘 | Mostafa F Harrison T M Grove M | 2001 | Journal of Sedimentary Research2001，71，3： | 1 |
| 18 | Treatment of distal radial fractures with antegrade intra - medullary Kirschner wires 显示文摘 | Mostafa M F | 2013 | Strat Trauma Limb Reconstr2013，2，： | 1 |
| 19 | DG allocation for benefit maximization in distribution networks 显示文摘 | Mostafa F Yasser M Ehab F | 2013 | IEEE Transac- tions on Power Systems2013，28，2： | 1 |
| 20 | Wave-induced responses in a fluidfilled poro-elastic solid with a free surface boundary layer theory 显示文摘 | Chiang C M Mostafa A F | 1981 | Geophys J R Astr Soc1981，66，： | 1 |
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