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您的检索式：作者名="Mostafa Ellabaan"
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| 1 | Antibiotic Treatment Drives the Diversification of the Human Gut Resistome显示文摘Despite the documented antibiotic-induced disruption of the gut microbiota, the impact of antibiotic intake on strain-level dynamics, evolution of resistance genes, and factors influencing resistance dissemination potential remains poorly understood. To address this gap we analyzed public metagenomic datasets from 24 antibiotic treated subjects and controls, combined with an in-depth prospective functional study with two subjects investigating the bacterial community dynamics based on cultivation-dependent and independent methods. We observed that shortterm antibiotic treatment shifted and diversified the resistome composition, increased the average copy number of antibiotic resistance genes, and altered the dominant strain genotypes in an individual-specific manner. More than 30% of the resistance genes underwent strong differentiation at the single nucleotide level during antibiotic treatment. We found that the increased potential for horizontal gene transfer, due to antibiotic administration, was ~3-fold stronger in the differentiated resistance genes than the non-differentiated ones. This study highlights how antibiotic treatment has individualized impacts on the resistome and strain level composition, and drives the adaptive evolution of the gut microbiota. | Jun Li Elizabeth A.Rettedal Eric van der Helm Mostafa Ellabaan Gianni Panagiotou Morten O.A.Sommer | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 4 |
| 2 | Corrigendum to“Antibiotic Treatment Drives the Diversification of the Human Gut Resistome”[Genomics Proteomics Bioinformatics 17(1)(2019)39-51]显示文摘The editors regret there was an error in“Shotgun metagenome library construction and sequencing”section.“The raw sequences can be found in BGID(CRA000815)”should be corrected to“The raw metagenome sequencing data have been deposited in the Genome Sequence Archive at Beijing Institute of Genomics,Chinese Academy of Sciences(GSA:CRA000815),and are publicly accessible at http://gffzzdbc7b6aaae734bddsc65fpuxxpqqf6f5b.ffgz.tsg.suse.edu.cn/gsa/”.The correct section is shown below.The editors would like to apologize for any inconvenience caused. | Jun Li Elizabeth A.Rettedal Eric van der Helm Mostafa Ellabaan Gianni Panagiotou Morten O.A.Sommer | 2020 | Genomics, Proteomics & Bioinformatics2020，18，5： | 0 |
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