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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Functional analysis of receptor-like ki- nases in monocots and dicots显示文摘 | MORILLO S A TAX F E | 2006 | Current Opinion in Plant Biolo- gy2006，9，5： | 1 |
| 3 | Inappropriate si- nus tachycardia: current therapeutic options显示文摘 | Femenla F Baranchuk A Morillo C A | 2012 | Cardiol Rev2012，20，1： | 1 |
| 4 | Interdisciplinarity in science: A tentative topology of disciplines and research areas显示文摘 | Morillo F Bordons M G6mez I | 2003 | Journal of the American Society for Information Science and Technology2003，54，13： | 1 |
| 5 | Evaluation of population parameters and mathematical strategies for the calculation of prenatal risk of Down syndrome in the first trimester of pregnancy 显示文摘 | MART GARdA B P CALVO F M | 2012 | Prenatal Diagnosis2012，32，3： | 1 |
| 6 | An accelerometer-based device for sleep apnea screening显示文摘 | Morillo D S Ojeda J L R Foix L F C | 2010 | IEEE Transactions on Information Technology in Biomedicine2010，14，2： | 1 |
| 7 | Interdisciplinarity in science: a tentative typology of disciplines and research areas 显示文摘 | Morillo F Bordons M G6mez I | 2003 | Journal of the American Society for Information Science and Technology2003，54，13： | 1 |
| 8 | An approach to interdisciplinarity through bibliometric indicators 显示文摘 | Morillo F Bordons M G6mez I | 2001 | Scientometrics2001，51，1： | 1 |
| 9 | Interdisciplinary in science: a tentative typology of disciplines and research areas显示文摘 | MORILLO F BORDONS M GMEZ I | 2003 | Journal of the American Society for Information Science and Technology2003，54，13： | 1 |
| 10 | Porous polyethylene implants in orbital floor reconstruction 显示文摘 | Villarreal PM Monje F Morillo A J | 2002 | Plast Reconstr Surg2002，109，3： | 1 |
| 11 | Analysis of the polymorphism in the hMSH2 gene in lymphoma and leukemia显示文摘 | Paz-y-Mino C Fiallo B F Morillo S A | 2003 | Leuk Lymphoma2003，44，3： | 1 |
| 12 | An approach to inter-disciplinarity through bibliometric indicators 显示文摘 | MORILLO F BORDONSM G6MEZ I | 2001 | Scientomet-rics2001，51，1： | 1 |
| 13 | An approach to interdisciplinarity through bibliometric indicators 显示文摘 | Morillo F Bordons M G6mez I | 2001 | Scientometfics2001，51，1： | 1 |
| 14 | Interdisciplinarity in science: A tentative typology of disciplines and research areas 显示文摘 | Morillo F Bordons M Gomez I | 2003 | Journal of the American Society for Information Science and Technology2003，54，13： | 1 |
| 15 | cerebral hemispheric lateralization in cardiac autonomic control显示文摘 | Yoon B L Morillo C A Cechetto D F | 1997 | Arch Neurol1997，54，6： | 1 |
| 16 | Formulation affecting alachlor efficacy and persistence in sandy soils 显示文摘 | SOPEIqA F MAQUEDA C MORILLO E | 2009 | Pest Manag Sci2009，65，7： | 1 |
| 17 | Functional analysis of receptor-like kinases in monocots and dicots显示文摘 | Morillo S A Tax F E | 2006 | Current Opinion in Plant Biology2006，9，5： | 1 |
| 18 | Interaction of pesticides with soluble fraction of natural and artifical humic substances显示文摘 | Morillo E Martin F | 1993 | J Environ Sci Health1993，28，6： | 1 |
| 19 | An approach to interdisciplinarity through bibliometric indicators 显示文摘 | Morillo F Bordons M G6mez I | 2001 | Scientometrics2001，51，1： | 1 |
| 20 | Towards the Automation of Address Identification 显示文摘 | Morillo F Aparicio J Gonzlez-Albo B | 2013 | Scientometrics2013，94，1： | 1 |
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