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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Age-dependent effect of beta blockers in preventing vasovagal syncope显示文摘 | Sheldon R S Morillo C A Klingenheben T | 2012 | Circ Ar- rhythmElectrophysiol2012，5，5： | 1 |
| 3 | Chronic rapid atrial pacing structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibriltation显示文摘 | MORILLO C A KLEIN G J JONES D L | 1995 | Circulation1995，91，： | 1 |
| 4 | The effect of dissolved glyphosate upon the sorption of copper by three selected soils显示文摘 | Morillo E Undabeytia T Maqueda C | 2002 | Chemosphere2002，47，： | 1 |
| 5 | Chronic rapid atrial pacing: structural, functional, and electrophysiological characteristics of a new modelof sustained atrial fibrillation 显示文摘 | Morillo C A Klein G J Jones D L | 1995 | Circulation1995，91，5： | 1 |
| 6 | Mutual in fluence of Cu and a cationic herbicide on their adsorption desorp tion processes on two selected soils显示文摘 | Undabeytia T Morillo E Ramos A B Maqueda C | 2002 | Water Air and Soil Pollution2002，137，14： | 1 |
| 7 | Effect of organic amendments on the retention and mobility of imazaquin in soils显示文摘 | Undabeytia T Morillo E Maqucda C 2004 | 2004 | J Agric Food Chem2004，52，： | 1 |
| 8 | Inappropriate si- nus tachycardia: current therapeutic options显示文摘 | Femenla F Baranchuk A Morillo C A | 2012 | Cardiol Rev2012，20，1： | 1 |
| 9 | Theoretical stress concentration factors for short flat tension bars with opposite U-shaped notches显示文摘 | Gomes C J Troyani N Morillo C | 2005 | Journal of Strain Analysis2005，40，4： | 1 |
| 10 | Improved Certificate-based Encryption in the Standard Model显示文摘 | Galindo D Morillo P Rdfols C | 2008 | Journal of System and Software2008，81，7： | 1 |
| 11 | Adsoption of chlordimeform by humic substances from different soils显示文摘 | MAQUEDA C MORILLO E PEREZ RODRIQUEZ J L | 1990 | Soil Science1990，150，： | 1 |
| 12 | Role of the renin-angiotensin-aldosterone system in atrial fibrillation and cardiac remodeling显示文摘 | HEALEY J S MORILLO C A CONNOLLY S J | 2005 | Curr Opin Cardiol2005，20，： | 1 |
| 13 | Effect of the simulta- neous addition of ffcyclodextrin and the herbicide norflura- zon on its adsorption and movement in soils 显示文摘 | Villaverde J Maqueda C Morillo E | 2006 | J Agric Food Chem2006，54，： | 1 |
| 14 | Retention of copper by a calcareous soil and its textural fractions: Influence of amendment with two agroindustrial residues显示文摘 | Rodriguez-rubio P Morillo E Madrid L Undabeytia T Maqueda C | 2003 | European Journal of Soil Science2003，5，： | 1 |
| 15 | An accelerometer-based device for sleep apnea screening显示文摘 | Morillo D S Ojeda J L R Foix L F C | 2010 | IEEE Transactions on Information Technology in Biomedicine2010，14，2： | 1 |
| 16 | Chronic rapidatrial pacing,structural,function and electrophysiological characteristics of new model of sustainedatrial fihrillation显示文摘 | MORILLO C A KLEIN G J JONES D L | 1995 | Circulation1995，91，： | 1 |
| 17 | Density functional study of copper segregation in aluminum显示文摘 | Benali A Lacaze-Dufaure C Morillo J | 2011 | Surface Science2011，，605： | 1 |
| 18 | Chronic Rapid Atrial Pacing:Structural, Functional,and Electrophysiological Characteristics of a New Model of Sustained Atrial Fibrillation显示文摘 | Morillo C A Klein G J Jones D L | 1995 | Circulation1995，91，5： | 1 |
| 19 | Improvement of the Desorption of the Herbicide Norflurazon from Soils Via Complexation with β-Cyclodextrin 显示文摘 | VILLAVERDE J MAQUEDA C MORILLO E | 2005 | J Agric Food Chem2005，53，： | 1 |
| 20 | Improved certificate-based en- cryption in the standard model显示文摘 | Galindo D Morillo P Rafols C | 2008 | The Journal of Systems and Software2008，81，： | 1 |
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