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| 1 | Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy显示文摘An inflammatory pseudotumor (IPT) is a relatively rare lesion characterized by chronic inf iltration of inflammatory cells and areas of f ibrosis. IPTs are diff icult to diagnose because of the absence of specif ic symptoms or of characteristic hematological or radiological f indings. In this study, a case of a woman aged over 70 years was reported, who presented with a general malaise lasting more than two months. A computed tomography scan demonstrated a diffusely spread lesion of the liver with a portal vein occlusion and a splenic lesion surrounded by a soft density layer. Since the percutaneous liver biopsy showed f indings that suggested an IPT, although the radiological f indings did not exclude the possibility of a malignancy, we performed a percutaneous spleen biopsy to enable a more defi nitive diagnosis. The microscopic f indings from the spleen specimen lead us to a diagnosis of IPT involving the liver and spleen. Sub-sequent steroid pulse therapy was effective, and rapid resolution of the disease was observed. | Tsukasa Kawaguchi Kiyoshi Mochizuki Takashi Kizu Masanori Miyazaki Takayuki Yakushijin Shusaku Tsutsui Eiichi Morii Tetsuo Takehara | 2012 | World Journal of Gastroenterology2012，18，1： | 11 |
| 2 | Cranial base chordoma——long term outcome and review of the literature显示文摘BACKGROUND: The purpose of this study is to clarify the latest long-term therapeutic result for cranial base chordomas.We are seeking an improvement of long term therapeutic outcome through a review of cranial base chordomas treated in | Yoneoka Y Tsumanuma I Fukuda M Tamura T Morii K Tanaka R Fujii Y | 2008 | 中国神经肿瘤杂志2008，6，3： | 9 |
| 3 | 铁矿石烧结过程二恶英排放的影响因素研究显示文摘通过采用2水平7因素正交试验设计(L8(2^7))的烧结锅试验,研究了影响烧结机二恶英排放的相关因素。EP灰、BF灰和外购氧化铁皮是二恶英排放的主要"促进剂",而生石灰是二恶英排放的"抑制剂"。对各影响因素而言,二恶英的排放模型并不是加和模型而是乘积模型,对应于添加5%EP灰、5%BF灰、5%外购氧化铁皮和2%生石灰时,它们的系数分别为28、4、4和0.7。至于操作条件,包括料层高度、焦粉含量、气体流速和废气补燃器的开/关对二恶英排放没有显著影响。这些事实支持了烧结过程二恶英的合成为化学反应控制。 | Nakano Masanori Kawachi Shinji Morii Kazuyuki Sato Takehiko 齐伟(译) 俞勇梅(校) | 2012 | 世界钢铁2012，12，2： | 6 |
| 4 | Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses显示文摘Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses.However,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed analysis.Administration of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of GVHD.Immunization with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO mice.Immunization with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO mice.Adoptive cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T cells.ACTs using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be evaluated.Therefore,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice. | Tomonori Yaguchi Asuka Kobayashi Takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio Takashi Iwata Yuyo Ka Ikumi Katano Ryoji Ito Mamoru Ito Yutaka Kawakami | 2018 | Cellular & Molecular Immunology2018，15，11： | 6 |
| 5 | Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings显示文摘Basaloid squamous carcinoma(BSC)is a rare variant of esophageal cancer.There are very few reports of'early'BSC.Here we report a case of early BSC with unusual findings by narrowband imaging magnified endoscopy(NBI-ME).A 70-year-old man with a middle thoracic esophageal tumor was referred to our hospital.White-light endoscopy revealed a reddish depressed lesion 5 mm in diameter having a subepithelial tumor-like prominence with a gentle rising slope.NBI-ME revealed irregular loop-shaped microvessels coexistent with thick irregularly branched non-looped vessels.Iodine staining revealed a pale brown lesion.We performed endoscopic submucosal dissection for diagnostic treatment.Histologic examination showed the proliferation of basal cell-like hyperchromatic tumor cells in the lamina propria and with slight invasion into the submucosa at a depth of 320μm.The tumor cells formed solid nests and microcystic structures,containing an Alcian blue-positive mucoid matrix.The surface was covered with squamous epithelium without cellular atypia.Thin vessels were observed in the intra-epithelial papilla and thick vessels were observed around the solid nests beneath the epithelium.Based on these findings together,we diagnosed the lesion as BSC.In this case,the NBI-ME findings differed from those of typical squamous cell carcinoma in that both non-invasive cancer-like irregular loop-shaped microvessels coexisted with massively invasive cancerlike thick non-looped vessels.We speculate that the looped and non-looped vessels observed by NBI-ME histologically corresponded to thin vessels in the intraepithelial papilla and thick vessels around the tumor nests,respectively.These NBI-ME findings might be a feature of early esophageal BSC. | Yugo Kai Motohiko Kato Yoshito Hayashi Tomofumi Akasaka Shinichiro Shinzaki Tsutomu Nishida Masahiko Tsujii Eiichi Morii Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，35： | 4 |
| 6 | Multicenter phase II study of weekly paclitaxel plus S-1 combination chemotherapy in patients with advanced gastric cancer显示文摘 | Yuji Ueda Hisakazu Yamagishi Daisuke Ichikawa Kazuma Okamoto Eigo Otsuji Jun Morii Kinya Koizumi Naoki Kakihara Masataka Shimotsuma Tetsuro Yamashita Fumihiro Taniguchi Hideki Aragane Hiroshi Nishi Yoshiki Itokawa Satoshi Morita Junichi Sakamoto | 2010 | Gastric Cancer2010，，3： | 2 |
| 7 | 玻璃纤维/大麻纤维增强聚丙烯混杂复合材料的力学性能和断裂特征(英文)显示文摘目前在土木工程,建筑,汽车等领域里使用的复合材料中,玻璃纤维是用量最大的增强材料。由于保护地球环境的呼声日趋高涨,天然纤维被期待着代替源于石油而且再利用困难的玻璃纤维,成为绿色复合材料的必要材料之一。本文通过注射成型工艺制作了玻璃短纤维,大麻短纤维以及混杂型纤维增强复合材料,并在拉伸实验中应用两种不同频率的声发射技术检测了拉伸断裂特性。实验发现,随着大麻纤维的加入和混杂复合材料绿色度的增加,复合材料的拉伸弹性模量随之线性增大,而拉伸强度基本保持不变。当大麻纤维的含量超过20wt%的时候,拉伸强度开始降低。在不同频率的声发射实验中,混杂型复合材料的声发射事件的产生都比单一纤维增强型复合材料要来的晚,也就是说,纤维的混杂有助于推迟微裂纹的产生。 | Tomoko OHTA Tohru MORII Hiroyuki HAMADA | 2009 | 材料工程2009，37，S2： | 2 |
| 8 | Twenty four-week peginterferon plus ribavirin after interferon-β induction for genotype 1b chronic hepatitis C显示文摘AIM:To investigate the possibility of shortening the duration of peginterferon(Peg-IFN)plus ribavirin(RBV) combination therapy by incorporating interferon-β (IFN-β)induction therapy. METHODS:A one treatment arm,cohort prospective study was conducted on seventy one patients.The patients were Japanese adults with genotype 1b chronic hepatitis C,HCV-RNA levels of≥5.0 Log IU/mL or 100 KIU/mL,and platelet counts of≥90 000/μL.The treatment regimen consisted of a 2 wk course of twicedaily administration of IFN-βfollowed by 24 wk PegIFN plus RBV combination therapy.We prolonged the duration of the Peg-IFN plus RBV therapy to 48 wk if the patient requested it. RESULTS:The patients,including 44%males,were characterized by an median age of 63 years(range: 32-78 years),an median platelet count of 13.9(range: 9.1-30.6)×10 4 /μL,62%IFN-na?ve,and median HCV- RNA of 6.1(range:5.1-7.2)Log IU/mL.The sustained virologic response(SVR)rates were 34%(Peg-IFN:1-24 wk,n=61,95%confidence interval(CI): 24%-47%)and 55%(Peg-IFN:20-24 wk,n=31,95% CI:38%-71%,P<0.001;vs Peg-IFN:1-19 wk).TheSVR rate when the administration was discontinued early was 13%(Peg-IFN:1-19 wk,n=30,95%CI: 5%-30%),and that when the administration was prolonged was 50%(Peg-IFN:25-48 wk,n=10,95% CI:24%-76%,P<0.05;vs Peg-IFN:1-19 wk).In the patients who received 20-24 wk of Peg-IFN plus RBV,only the higher platelet count(≥130 000/μL) was significantly correlated with the SVR(odds ratio: 11.680,95%CI:2.3064-79.474,P=0.0024).In 45% (14/31)of the patients with a higher platelet count (≥130000/μL)before therapy,the HCV-RNA level decreased to below 3.3 Log IU/mL at the completion of IFN-β,and their SVR rate was 93%(13/14)after 20-24 wk administration of Peg-IFN plus RBV. CONCLUSION:These results suggest the possibilities of shortening the duration of Peg-IFN plus RBV combination therapy by actively reducing HCV-RNA levels using the IFN-βinduction regimen. | Hiroaki Okushin Kazuhiko Morii Koichi Uesaka Shiro Yuasa | 2010 | World Journal of Hepatology2010，2，6： | 2 |
| 9 | Ultracytochemical demonstration of phospholipids in the surface layer of the guinea pig eustachian tube显示文摘 | Tsuruhara K Moriis Kumazawa T | 1989 | Acta Otolaryngol1989，108，56： | 2 |
| 10 | Short-term intravenous interferon therapy for chronic hepatitis B显示文摘AIM:To investigate the therapeutic efficacy of short- term, multiple daily dosing of intravenous interferon (IFN) in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B. METHODS:IFN-β was intravenously administered at a total dose of 102 million international units (MIU) over a period of 28 d in 26 patients positive for HBeAg and HBV-DNA. IFN-beta was administered at doses of 2 MIU and 1 MIU on d 1, 3 MIU twice daily from d 2 to d 7, and 1 MIU thrice daily from d 8 to d 28. Patients were followed up for 24 wk after the end of treatment. RESULTS:Six months after the end of the treatment, loss of HBV-DNA occurred in 13 (50.0%) of the 26 patients, loss of HBeAg in 9 (34.6%), development of anti-HBe in 10 (38.5%), HBeAg seroconversion in 8 (30.8%), and normalization of alanine aminotransferase (ALT) levels in 11 (42.0%). CONCLUSION:This 4-wk long IFN-β therapy, which was much shorter than conventional therapy lasting 12 wk or even more than 1 year, produced therapeutic effects similar to those achieved by IFN-α or pegylated- IFN-α (peg-IFN). Fewer adverse effects, greater efficacy, and a shorter treatment period led to an improvement in patients’ quality of life. IFN-β is administered intravenously, whereas IFN-α is administered intramuscularly or subcutaneously. Because both interferons are known to bind to an identical receptor and exert antiviral effects through intracellular signal transduction, the excellent results of IFN-β found in this study may be attributed to the multiple doses allowed by the intravenous route. | Hiroaki Okushin Toru Ohnishi Kazuhiko Morii Koichi Uesaka Shiro Yuasa | 2008 | World Journal of Gastroenterology2008，14，19： | 2 |
| 11 | Occult myofibroblastic sarcoma detected on FDG-PET performed for cancer screening 显示文摘 | MORII T MOCHIZUKI K SANO H | 2008 | Ann Nucl Med2008，22，9： | 1 |
| 12 | Total synthesis of valeriananoids A, B, and C via autocatalytic diastereoselective domino Michael reaction 显示文摘 | Masakazu Fukushima Akihiro Morii Takashi Hoshi Toshio Suzuki Hisahiro Hagiwara | 2007 | Tetrahedron2007，63，30： | 1 |
| 13 | Loop mediated isothermal amplification (LAMP) of gene sequences and simple visual detection ofproducts显示文摘 | Tomita N MoriY Kanda H etal | 2008 | Nat Protoc2008，3，5： | 1 |
| 14 | rho GAP of 28 kDa (GAP2), but not of 190 kDa (p190) , requires Asp65 and Asp67 of rho GTPase for its activation显示文摘 | Morii N Kumagai N Nur-E-Kamal MS | 1993 | J Biol Chem1993，268，27： | 1 |
| 15 | Evaluation of anorectal function in patients with tethered cord syndrome: saline enema test and fecoflowmetry 显示文摘 | Kayaba H Hebiguchi T Itoh Y Yoshino H Mizuno M Morii M | 2003 | J Neurosurg2003，98，3： | 1 |
| 16 | SGG10-related neuronal growth-associated proteins in neural development,plasticity,degeneration,and aging显示文摘 | Mori N Morii H | 2002 | J Neurosci Res2002，70，： | 1 |
| 17 | Possible relationship between adiponectin and renal tubular injury in diabetic nephropathy 显示文摘 | Fujita H Morii T Koshimura J | 2006 | Endocr J2006，53，6： | 1 |
| 18 | Development of mast cells: analysis with mutant mice显示文摘 | Morii E | 2007 | Int J Hematol2007，86，1： | 1 |
| 19 | Regulatory interaction of sodium channel IQ-motif with calmodulin C-terminal lobe显示文摘 | Mori M Konno T Morii T | 2003 | Biochem Biophys Res Commun2003，307，2： | 1 |
| 20 | Stereotactic aspiration in hyper-tensive pontine hemorrhage:comparative studywith conservative thera-py显示文摘 | Takahama H Morii K Sato M | | 0，，： | 1 |
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