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| 1 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 2 | A functional interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEA显示文摘 | Hallberg M Morganstein D L Kiskinis E | 2008 | Mol Cell Biol2008，28，22： | 1 |
| 3 | The role of arterial stimulation and simultaneous venous sampling in addition to cross-sectional imaging for localisation of bio- chemically proven insulinoma显示文摘 | Morganstein DL Lewis DH Jackson J | 2009 | Eur Radiol2009，19，10： | 1 |
| 4 | Receptor in- teracting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha 显示文摘 | DEBEVEC D CHRISTIAN M MORGANSTEIN D | 2007 | Mol Endocrinol2007，21，7： | 1 |
| 5 | Role of RIP140 in metabolic tissues: Connections to disease显示文摘 | White R Morganstein D Christian M | 2008 | FEBS Letters2008，582，1： | 1 |
| 6 | A functional interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEA显示文摘 | Hallberg M Morganstein DL Kiskinis E | | 0，，22： | 1 |
| 7 | The role of arterial stimulation and simultaneous venous sampling in addition to crosssectional imaging for localisation of biochemically proven insulino- ma 显示文摘 | Morganstein DL Lewis DH Jackson J | 2009 | Eur Radiol2009，19，10： | 1 |
| 8 | Test, revision, and cross-vali- dation of the physical activity self-definition model 显示文摘 | KENDZIERSKI D MORGANSTEIN M S | 2009 | Journal of Sport & Exercise Psychology2009，31，4： | 1 |
| 9 | Military family physician attitudes toward treating obesity 显示文摘 | Warner CH Warner CM Morganstein J | 2008 | Mil Med2008，173，10： | 1 |
| 10 | Role of RIP140 in metabolic tissues: connections to disease显示文摘 | White R Morganstein D Christian M | 2007 | FEBS Lett2007，582，1： | 1 |
| 11 | Low TSH in a patient with primary hypothyroidism显示文摘 | Morganstein D Mendoza N Strickland N | 2005 | R Soc Med2005，98，： | 1 |
| 12 | The role of arterial stimulation and simultaneous venous sampling in addition to cross-sectional imaging for localization of biochemically proven insulinoma 显示文摘 | Morganstein DL Lewis DH Jackson J | 2009 | Eur Radiol2009，19，10： | 1 |
| 13 | The role of arterial stimulation and simultaneous venous sampling in addition to crosssectional imaging for localisation of biochemically proven in- sulinoma显示文摘 | Morganstein DL Lewis DH Jackson J | 2009 | Eur Radiol2009，19，10： | 1 |
| 14 | Prevalence of di-abetes in patients admitted to a cancer hospital显示文摘 | MORGANSTEIN D L TAN S GORE M | 2012 | Brit J DiabetVascul Dis2012，12，4： | 1 |
| 15 | Role of RIP140 in metabolic tissues:connections to disease显示文摘 | White R Morganstein D Christian M | | 0，，1： | 1 |
| 16 | Simultaneous relapse of Graves' disease and minimal change glomerular disease 显示文摘 | Holt S Kingdon E Morganstein D | 2002 | Nephrol Dial Transplant2002，17，4： | 1 |
| 17 | Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha显示文摘 | Debevec D Christian M Morganstein D | | 0，，： | 1 |
| 18 | Role of RIP140 in metabolic tissues:connections to disease显示文摘 | White R Morganstein D Christian M | 2008 | FEBS Lett2008，582，1： | 1 |
| 19 | Pancreatic surgery and tertiary pancreatitis services warrant provision for support from a specialist diabetes team显示文摘Pancreatic surgery units undertake several complex operations,albeit with consi-derable morbidity and mortality,as is the case for the management of complicated acute pancreatitis or chronic pancreatitis.The centralisation of pancreatic surgery services,with the development of designated large-volume centres,has contribu-ted to significantly improved outcomes.In this editorial,we discuss the complex associations between diabetes mellitus(DM)and pancreatic/periampullary disease in the context of pancreatic surgery and overall management of complex pancreatitis,highlighting the consequential needs and the indispensable role of specialist diabetes teams in support of tertiary pancreatic services.Type 3c pan-creatogenic DM,refers to DM developing in the setting of exocrine pancreatic disease,and its identification and management can be challenging,while the glycaemic control of such patients may affect their course of treatment and outcome.Adequate preoperative diabetes assessment is warranted to aid identification of patients who are likely to need commencement or escalation of glucose lowering therapy in the postoperative period.The incidence of new onset diabetes after pancreatic resection is widely variable in the literature,and depends on the type and extent of pancreatic resection,as is the case with pancreatic parenchymal loss in the context of severe pancreatitis.Early involvement of a specialist diabetes team is essential to ensure a holistic management.In the current era,large volume pancreatic surgery services commonly abide by the principles of enhanced recovery after surgery,with inclusion of provisions for optimisation of the perioperative glycaemic control,to improve outcomes.While various guidelines are available to aid perioperative management of DM,auditing and quality improvement platforms have highlighted deficiencies in the perioperative management of diabetic patients and areas of required improvement.The need for perioperative support of diabetic patients by specialist diabetes teams is uniformly underlined,a fact that becomes clearly more prominent at all different stages in the setting of pancreatic surgery and the management of complex pancreatitis.Therefore,pancreatic surgery and tertiary pancreatitis services must be designed with a provision for support from specialist diabetes teams.With the ongoing accumulation of evidence,it would be reasonable to consider the design of specific guidelines for the glycaemic management of these patients. | Vasileios K Mavroeidis Jennifer Knapton Francesca Saffioti Daniel L Morganstein | 2024 | World Journal of Diabetes2024，15，4： | 0 |
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