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| 1 | Differential colorectal carcinogenesis:Molecular basis and clinical relevance显示文摘Colorectal cancer(CCR) is one of the most frequent cancers in developed countries.It poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal cancer.It has been established that sporadic CCRs can arise from at least two different carcinogenic pathways.The traditional pathway,also called the suppressor or chromosomal instability pathway,follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes,such as K-ras,adenomatous polyposis coli,deleted in colorectal cancer,or p53.Alterations in the Wnt pathway are also very common in this type of tumour.The second main colorectal carcinogenesis pathway is the mutator pathway.This pathway is present in nearly 15% of all cases of sporadic colorectal cancer.It is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the DNA mismatch repair genes,mostly in hMLH1 or hMSH2.These two pathways have clear molecular differences,which will be reviewed in this article,but they also present distinct histopathological features.More strikingly,their clinical behaviours are completely different,having the 'mutator' tumours a better outcome than the 'suppressor' tumours. | Alberto Morán Paloma Ortega Carmen de Juan Tamara Fernández-Marcelo Cristina Frías Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Pilar Iniesta Manuel Benito | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 5 |
| 2 | Bacterial adherence to bleached surfaces of composite resin in vitro显示文摘 | Mor C Steinberg D Dogan H | 1998 | OralSurg Oral Med Oral Pathol Oral Radiol Endod1998，86，5： | 1 |
| 3 | Beneficial effect of Lamivudine in recurrent hepatitis B after liver transplantation 显示文摘 | Ben- Ari Z Shmueli D Mor E | 1997 | Transplantation1997，63，： | 1 |
| 4 | Multiple Stumbles: A risk factor for falls in community - dwelling olderly 显示文摘 | Teno J Kiel D Mor V | 1990 | J Ame Geriatr Soc1990，38，12： | 1 |
| 5 | Role of naturally oc- curring CD4^+CD25^+regulatory T cells in experimental ath- eroselerosis 显示文摘 | Mor A Planer D Luboshits G | 2007 | Arterioseler Thromb Vase Biol2007，27，4： | 1 |
| 6 | Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes显示文摘 | Rapaport D Mor A | 1992 | Biochemistry1992，31，12： | 1 |
| 7 | Macrophages, estrogen and the microenvironment of breast cancer 显示文摘 | Mor D Yue W Santen R etal | 1998 | J Steroid Biochem Mol Bio11998，67，56： | 1 |
| 8 | Role of naturally occurring CD4 + CD25 + regulatory T cells in experimental atherosclerosis 显示文摘 | Mor A Planer D Luboshits G | 2007 | Arterioscler Thromb Vase Biol2007，27，： | 1 |
| 9 | Bacterial adherence to bleached surfaces of composite resin in vitro显示文摘 | Mor C Steinberg D Dogan H | 1998 | Oral Surg Oral Med Oral Pathol1998，86，5： | 1 |
| 10 | Weekend versus weekday admission and mortality after acute pulmonary embolism显示文摘 | Aujesky D Jimenez D Mor MK | | 0，，： | 1 |
| 11 | DNA amplificate in human gastric cancer显示文摘 | Mor D | 1993 | Cancer Genet Cyto-genet1993，65，2： | 1 |
| 12 | Methodology, design, and analytic techniques to address measurement of comorbid disease 显示文摘 | Lash TL Mor V Wieland D | 2007 | J Gerontol A Bioi Sci Med Sci2007，62，3： | 1 |
| 13 | Unextendible product bases,uncompletable product bases and bound entanglement显示文摘 | DiVincenzo D P Mor T Shor P W | 2003 | Communication in Math Phys2003，238，： | 1 |
| 14 | Weekend versus weekday admission and mortality after acute pulmonary embolism 显示文摘 | Aujesky D Jim6nez D Mor MK | 2009 | Cir- culation2009，119，： | 1 |
| 15 | Combined functional and structural evaluation of cancer patients with hybrid camera based PET/CT system using 18F-FDG显示文摘 | Israel O Mor M Gaitini D | 2002 | J Nucl Med2002，43，9： | 1 |
| 16 | Combined functional and structural evaluation of cancer patients with a hybrid camera-based PET/CT system using 18F-FDG显示文摘 | Israel O Mor M Gaitini D | 2002 | J Nucl Med2002，43，9： | 1 |
| 17 | Altered status of CD4^+ CD25^+ regulatory T cells in patients with acute coronary syn- dromes显示文摘 | Mor A Luboshits G Planer D | 2006 | Eur Heart J2006，27，21： | 1 |
| 18 | The potential of colour measurement forstrength prediction of thermally treated wood显示文摘 | JOHANSSON D MOR?N T | 2006 | Holz als Roh-und Werk-stoff2006，64，5： | 1 |
| 19 | Alfalfa Yield and Quality as Influenced by Establishment Method显示文摘 | Michael D Hoy Kenneth J Mor | 2002 | 94( 1 - 2) : 1163 - 11702002，94，12： | 1 |
| 20 | Benchmarking optimization software with performance profiles显示文摘 | Dolan E D Morè J J | 2002 | Math Program2002，91，： | 1 |
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