|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer显示文摘AIM: To investigate the correlation between uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphisms and irinotecan-associated side effects and parameters of drug efficacy in patients with metastatic colorectal cancer (mCRC) receiving a low-dose weekly irinotecan chemotherapeutic regimen. METHODS: Genotypes were retrospectively evaluated by gene scan analysis on the ABI 310 sequencer of the TATAA box in the promoter region of the UGT1A1 gene in blood samples from 105 patients who had received 1st line irinotecan-based chemotherapy for mCRC. RESULTS: The distribution of the genotypes was as follows: wild type genotype (WT) (6/6 ) 39.0%, heterozygous genotype (6/7) 49.5%, and homozygous genotype (7/7) 9.5%. The overall response rate (OR) was similar between patients carrying the (6/7, 7/7) or the WT genotype (6/6) (44.3% vs 43.2%, P = 0.75). Neither time to progression [(TTP) 8.1 vs 8.2 mo, P = 0.97] nor overall survival [(OS) 21.2 vs 18.9 mo, P = 0.73] differed significantly in patients who carried the(6/6) when compared to the (6/7, 7/7) genotype. No significant differences in toxicity were observed: Grade 3 and 4 delayed diarrhoea [(6/7, 7/7) vs (6/6); 13.0% vs 6.2%, P =0.08], treatment delays [(6/7, 7/7) vs (6/6); 25.1% vs 19.3%, P = 0.24] or dose reductions [(6/7, 7/7) vs (6/6); 21.5% vs 27.2%, P = 0.07].CONCLUSION: This analysis demonstrates the non-significant influence of the UGT1A1 gene polymorphism on efficacy and rate of irinotecan-associated toxicity in mCRC patients receiving low-dose irinotecan based chemotherapy. | Christoph Schulz Volker Heinemann Andreas Schalhorn Nikolas Moosmann Thomas Zwingers Stefan Boeck Clemens Giessen Hans-Joachim Stemmler | 2009 | World Journal of Gastroenterology2009，15，40： | 31 |
| 2 | “En bloc ” caudate lobe and inferior vena cava resection following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal and liver metastasis of colorectal cancer显示文摘There are diverse protocols to manage patients with recurrent disease after primary cytoreductive surgery(CRS) with hyperthermic intraperitoneal chemotherapy(HIPEC) for peritoneal carcinomatosis. We describe a case of metachronous liver metastasis after CRS and HIPEC for colorectal cancer, successfully treated with a selective metastectomy and partial graft of the inferior vena cava. A 35-year-old female presented with a large tumour in the cecum and consequent colonic stenosis. After an emergency right colectomy, the patient received adjuvant chemotherapy. One year later she was diagnosed with peritoneal carcinomatosis, and it was decided to carry out a CRS/HIPEC. After 2 years of total remission, an isolated metachronous liver metastasis was detected by magnetic resonance imaging surveillance. The patient underwent a third procedure including a caudate lobe and partial inferior vena cava resection with a prosthetic graft interposition, achieving an R0 situation. The postoperative course was uneventful and the patient was discharged on postoperative day 17 after the liver resection. At 18-mo follow-up after the liver resection the patient remained free of recurrence. In selected patients, the option of re-operation due to recurrent disease should be discussed. Even liver resection of a metachronous metastasis and an extended vascular resection are acceptable after CRS/HIPEC and can be considered as a potential treatment option to remove all macroscopic lesions. | Patricia Sánchez-Velázquez Nicolas Moosmann Ingolf T?pel Pompiliu Piso | 2016 | World Journal of Gastroenterology2016，22，46： | 3 |
| 3 | High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D显示文摘Biodegradable magnesium(Mg)alloys can revolutionize osteosynthesis,because they have mechanical properties similar to those of the bone,and degrade over time,avoiding the need of removal surgery.However,they are not yet routinely applied because their degradation behavior is not fully understood.In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium(Gd)at high resolution.Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4,8 and 12 weeks.Afterward,the degradation rate and degradation homogeneity,as well as bone-to-implant interface,were studied with synchrotron radiation micro computed tomography and histology.Titanium(Ti)and polyether ether ketone(PEEK)were used as controls material to evaluate osseointegration.Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd.Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue.The results were correlated to in vitro data obtained from the same material and shape.The average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for PEEK.The results suggest that both Mg-xGd alloys are suitable as materials for bone implants. | Diana Krüger Silvia Galli Berit Zeller-Plumhoff D.C.Florian Wieland Niccolo Peruzzi Bjorn Wiese Philipp Heuser Julian Moosmann Ann Wennerberg Regine Willumeit-Romer | 2022 | Bioactive Materials2022，7，7： | 2 |
| 4 | Cetuximab plus oxalip latin2based chemotherapy in the treatment of colorectal cancer显示文摘 | Moosmann N Heinemann V | 2008 | Expert Rev Anticancer Ther2008，8，3： | 1 |
| 5 | Correlates of alpha rhythm in functional magnetic resonance imaging and near infrared spectroscopy显示文摘 | Moosmann M Ritter P Krastel I | 2003 | Neuroimage2003，20，1： | 1 |
| 6 | The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties显示文摘 | Behl C | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 7 | Selenoprotein synthesis and side-effects of statins显示文摘 | Moosmann B Behl C | 2004 | Lancet2004，363，： | 1 |
| 8 | Thermal comfort and workplace occupant satisfaction-results of field studies in German low energy office buildings 显示文摘 | Wagner A Gossauer E Moosmann C | 2007 | Energy and Buildings2007，39，7： | 1 |
| 9 | 'Thermal comfort and workplace occupant satisfaction:Results of field studies in German low energy of ice buildings显示文摘 | A. Wagner E. Gossauer C. Moosmann T.Gropp and R.Leonhart | | 0，，： | 1 |
| 10 | Selenoprotein synthesis and side-effects of statins显示文摘 | Moosmann B Behl C | 2014 | Lancet2014，12，363： | 1 |
| 11 | B cells immortalized by a mini-Epstein-Ban' virus encoding a foreign antigen efficiently reacti- vate specific cytotoxic T cells 显示文摘 | Moosmann A Khan N Cobbold M | 2002 | Blood2002，100，5： | 1 |
| 12 | B cells immortalized by a mini-Epstein-Barr virus encoding a foreign antigen efficiently reactivate specific cytotoxic T cells 显示文摘 | Moosmann A Khan N Cobbold M | 2002 | Blood2002，100，5： | 1 |
| 13 | Selenoprotein synthesis and side - effects of statins 显示文摘 | Moosmann B Behl C | 2004 | Lancet2004，363，9412： | 1 |
| 14 | The EBV and BNLF2a protect newly infected B cells from immune recognition and elimination 显示文摘 | Jochum S Moosmann A Lang S | 2012 | PLoS Pathog2012，8，10： | 1 |
| 15 | Neoadjuvant and adjuant thera- pies for solid tumours 显示文摘 | HEINEMANN V MOOSMANN N | 2007 | MMW Fortschr Med2007，149，3536： | 1 |
| 16 | Cetuximab plus XELIRI or XELOX for first-line therapy of metastatic colorectal cancer显示文摘 | MOOSMANN N HEINEMANN V | 2008 | Clin Colorectal Cancer2008，7，2： | 1 |
| 17 | Nonmyeloablative Stem Cell Therapy Enhances Microcirculation and Tissue Regeneration in Murine Inflammatory Bowel Disease显示文摘 | Philipe N. Khalil Véronique Weiler Peter J. Nelson Maurice N. Khalil Sabine Moosmann Wolf E. Mutschler Matthias Siebeck Ralf Huss | 2007 | Gastroenterology2007，，3： | 1 |
| 18 | Engineering anti- gen-specific primary human NK cells against HER-2 positive carci- nomas显示文摘 | Kruschinski A Moosmann A Posehke I | 2008 | Proc Natl Acad Sei USA2008，105，17： | 1 |
| 19 | The EBV immunoevasins vIL-10 and BNLF2a protect newly infected B cells from immune recognition and elimination 显示文摘 | Jochum S Moosmann A Lang S | 2012 | PLoS Pathog2012，8，10： | 1 |
| 20 | Correlates of alpha rhythm in functional magnetic resonance imaging and near infrared spectroscopy显示文摘 | Matthias Moosmann | 2003 | NeuroImage2003，20，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员