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| 1 | Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation显示文摘AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation. METHODS: Primary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor. RESULTS: Genetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HSCs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-SMA, PDGFR and TGFβR. CONCLUSION: These data demonstrate unique clustered genetic profiles during the daily progression of HSC transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation. | Ashley M Lakner Cathy C Moore Alyssa A Gulledge Laura W Schrum | 2010 | World Journal of Gastroenterology2010，16，40： | 23 |
| 2 | 白细胞介素-10在T_H1和T_H2反应相互调节中的作用显示文摘对于T 辅助细胞(T_H)亚群的识别进一步加深了对免疫效应功能调节的了解。T_H 亚群除控制体液免疫和延迟型超敏反应以外,还通过分泌抑制性细胞因子来相互调节。Tim Mosmann 和Kevin Moore 分析总结了这些现象,尤其是由T_H 2细胞分泌的能够抑制T_H 1细胞功能的白细胞介素-10的作用。 | Tim R Mosmann Kevin W Moore 边立军 | 1992 | 国外医学(免疫学分册)1992，15，1： | 5 |
| 3 | 燃料成本性影响烤烟生产显示文摘烤烟生产需要投入大量的劳动力和燃料。在美国,燃料费用大概占生产烤烟成本的25%,其中大部分用于购买烘干烟叶所使用的由原油提炼的燃料。然而,在其它国家的烤烟生产中同样需要供应同等的能源来烘烤烟叶,这些系统通常使用其它燃料提供能源,例如木材。 | GIVAN W MOORE J M 迟立鹏(翻译) 康婧(校译) 赵百东(校译) | 2008 | 中国烟草学报2008，14，3： | 4 |
| 4 | 涂层和未涂层铝基体上接触应力的有限元模拟显示文摘基于对涂层/基体系统上产生的接触应力的分析,研究了软基体上薄膜的磨损行为。应用有限元法对由压头向涂层或未涂层铝基体施加正压力的情况进行模拟。先在没有薄膜的系统上对模型的精确性进行检验。然后通过改变薄膜的弹性模量比,开发出适用于铝基体上有两层硬薄膜试样的模型。同时还研究了薄膜厚度和载荷的影响。较厚的薄膜降低了模型上某些点的应力,但是增加了另一些点的应力。从弹性模量的角度来说,薄膜内的计算应力主要与薄膜的弹性模量有关,而通过改变薄膜的弹性模量比几乎不会使应力产生差异。 | J J Moore R M Souza G G W Mustoe 徐桂珍 | 2000 | 中国表面工程2000，13，1： | 4 |
| 5 | On definition of reactive power under non-sinusoidal conditions显示文摘 | Kusters N I Moore W J M | 1980 | IEEE Transactions on Power Apparatus and Systems1980，99，5： | 2 |
| 6 | Cycle prefix digraphs for symmetric interconnection networks显示文摘 | Moore J W Chen W Y C | 1992 | Networks1992，23，： | 1 |
| 7 | 显示文摘 | GAYLOR D W MOORE J A | 2004 | Regulatory Toxicology and Pharmacology2004，39，： | 1 |
| 8 | Comparative physiology of Synechococcus and Prochlorococcus : Influence of light and temperature on growth, pigments, fluorescence and absorptive properties显示文摘 | MOORE L R GOERICKE R CHISHOLM S W | 1995 | Marine Ecology Progress Series1995，116，： | 1 |
| 9 | The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor显示文摘 | WANG H W LI H MOORE L B | 2008 | Mol Endocrinol2008，22，4： | 1 |
| 10 | Recent advances in stream and river temperature research显示文摘 | WEBB B W HANNAH D M MOORE R D | 2008 | Hydrological Processes2008，22，7： | 1 |
| 11 | Association between polysomnographic sleep measures and health-related quality of life in obstructive sleep apnea显示文摘 | Moore P Bardwell W A Ancoli-Israel S | 2001 | J Sleep Res2001，10，4： | 1 |
| 12 | Magnetic disturbances preceding 1964 Alaska Earth quake 显示文摘 | Moore G W | 1964 | Nature1964，203，： | 1 |
| 13 | The percutaneous absorption of lead-203 in humans from cosmetic preparations containing lead acetate, as assessed by whole-body counting and other techniques 显示文摘 | Moore M Meredith P Watson W | 1980 | Food and Cosmetics Toxicology1980，18，： | 1 |
| 14 | Gelation and clarification of concentrated orange juices I introduction and present status显示文摘 | Wenzel F W Moore E L Rouse A H | 1951 | Food Technology1951，，5： | 1 |
| 15 | Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers显示文摘 | Millar A W Brown PD Moore J | 1998 | Br J Clin Pharmacol1998，45，1： | 1 |
| 16 | Methyl iodide distribution in the ocean and fluxes to the atmosphere 显示文摘 | Moore R M Groszko W | 1999 | Journal of Geophysical Research1999，104，11： | 1 |
| 17 | Recent advances in stream and river temperature research显示文摘 | Webb B W Hannah D M Moore R D | 2008 | Hydrological Processes2008，22，： | 1 |
| 18 | Interval analysis and fuzzy set theory显示文摘 | Moore R Lodwick W | 2003 | Fuzzy Sets and Systems2003，135，1： | 1 |
| 19 | Differential gene expression following early renal ischemia/reperfusion 显示文摘 | Supavekin S Zhang W Kucherlapati R Kaskel F J Moore L C Devarajan P | 2003 | Kid Int2003，63，： | 1 |
| 20 | The Lessons We (don't) Learn : Counterfactual Thinking and Organizational Accountability After a Close Call 显示文摘 | Morris M W Moore P C | 2000 | Administrative Science Quarterly2000，45，12： | 1 |
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