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| 1 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | Developmental changes in contraction of gastric smooth muscle cells in rats correlate with their differences in RhoA/ROCK pathway显示文摘Previous research has shown that smooth muscle of the stomach undergoes developmental changes in the intracellular regulatory mechanism responsible for the contractile process. Whether these developmental changes relate to differences in the expression and/or activity of the key enzymes regulating smooth muscle contraction has not been previously evaluated. Therefore, we aimed to examine the expression and activation of the small monomeric G protein 'Rho A' and Rho kinase(ROCK) as well as their correlation with the contraction of gastric smooth muscle cells(GSMCs) in newborn vs. adult rats. Freshly isolated single GSMCs from Sprague-Dawley rats at 1 week(newborn) and 3 months(adult) of age were used in the study. Protein and m RNA expression levels of both ROCK2 and total Rho A were higher in adult compared to newborn rats. Moreover, acetylcholine(ACh)-induced contractions of GSMCs in adult rats were significantly higher than that in newborn animals. Meanwhile,ROCK and Rho activation was higher in adult stomach cells compared to newborn ones. Pretreatment of GSMCs with Y-27632, the ROCK inhibitor, significantly reduced ACh-induced contraction in both groups of cells and greatly abolished contractile differences. In conclusion, our results indicate that Rho A/ROCK pathway and contraction of stomach muscle cells are under developmental regulation. | Othman Al-Shboul Mahmoud Alfaqih Ayman Mustafa Ahmed Al-Dwairi Mohammad Alqudah Saja Haifawi Mohanad Alebbini Mohammad Al-Zaareer Khobaib Alahmar | 2019 | The Journal of Biomedical Research2019，33，5： | 2 |
| 3 | Effect of vertical stress rest period on deformation behaviour of unbound granular materials:Experimental and numerical investigations显示文摘Repeated load triaxial test is used to assess the deformation behaviour of unbound granular materials(UGMs) in flexible road pavements. Repeated load pulse characteristics(i.e. shape, loading period and rest period) are the stress configurations used in the experimental set-up to simulate the passing axle loads. Some researchers and standard testing protocols suggest a rest period of varying durations after a loading phase. A thorough review of existing literature and practises has revealed that there is no agreement about the effect of the rest period of vertical stress pulse on the deformation behaviour of the UGMs. Therefore,the main objective of this study is to investigate the effect of repeated stress rest period on the deformation behaviour of UGMs experimentally. Experiments are conducted, both with and without rest period, using basalt and granite crushed rocks from Victoria, Australia. Furthermore, in order to gain insight into the effect of the rest period, finite element modelling is also developed. Both the experimental and modelling results show that the rest period has a noticeable effect on both resilient and permanent deformation behaviours of UGMs. It is, therefore, recommended to take extra precautions while adopting a particular standard testing protocol and to supplement the results by additional tests with different loading configurations. | Ali Alnedawi Kali Prasad Nepal Riyadh Al-Ameri Mohanad Alabdullah | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，1： | 2 |
| 4 | Characteristics and oil sorption effectiveness of kapok fibre, sugarcane bagasse and rice husks: oil removal suitability matrix显示文摘 | Norizan Ali Mohanad El-Harbawi AymanAbo Jabal Chun-Yang Yin | 2012 | Environmental Technology2012，，4： | 2 |
| 5 | Low temperature mechanism for the formation of poly- cyclic aromatic hydrocarbons from the pyrolysis of cellu- lose 显示文摘 | Thomas E McGrath Gedffrey Chan W Mohanad R Hajali- gol | 2003 | J Anal Appl Pyrol2003，66，： | 1 |
| 6 | Using GA for Optimi- zation of the fuzzy C-means clustering algorithm显示文摘 | Mohanad A Mohammad M Abdullah R | 2013 | Research Journal of Applied Sciences Engineering and Technology2013，5，3： | 1 |
| 7 | Man- agement of the difficult pediatric airway with Shikani显示文摘 | Mohanad Shukry Ryan D Hanson Joseph R Koveteskie | 2005 | Pediatric Anesthesia2005，15，4： | 1 |
| 8 | Management of the difficult pediatric airway with Shikani Optical Stylet显示文摘 | Mohanad S Ryan D Hanson | 2005 | Pediatric Anesthesia2005，15，： | 1 |
| 9 | In-office treatment of dentinal hypersensitivity显示文摘 | Mohanad MS Brown A Thomas DMD | 2009 | Dent Clin North Am2009，53，1： | 1 |
| 10 | Management of the difficult pediatric airway with Shikani 显示文摘 | Mohanad S Ryan DH Joseph R K | 2005 | Pediatric Anesthe- sia2005，15，4： | 1 |
| 11 | Osteoporosis and type 2 diabetes mellitus: what do we know, and what we can do?显示文摘 | S.A. Abdulameer Mohanad Sahib Subramaniam Hassali Sulaiman | 2012 | Patient Preference and Adherence (default)2012，，： | 1 |
| 12 | Update on dexmedetomidine: use in nonintubated patients requiring sedation for surgical procedures显示文摘 | Mohanad Shukry Jeffrey Miller | 2010 | Therapeutics and Clinical Risk Management (default)2010，，： | 1 |
| 13 | Estimating the existence value of north forests of Iran by using a contingent valuation method 显示文摘 | Amimejad H Khalilian S Mohanad H A | 2006 | Ecological Economics2006，57，： | 1 |
| 14 | Effect of frozen storage on physico-chemistry of wheat gluten proteins:Studies on gluten-,glutenin- and gliadin-rich fractions显示文摘 | Wang Pei Chen Hai-ying Mohanad B | 2012 | Food Hydrocolloids2012，，9： | 1 |
| 15 | Using GA for Optimization of the fuzzy C-means clustering algorithm显示文摘 | Mohanad A Mohammad M Abdullah R | 2013 | Research Journal of Applied Sciences Engineering and Technology2013，5，3： | 1 |
| 16 | Using GA for Optimization of the fuzzy C-means clustering algorithm显示文摘 | Mohanad A Mohammad M Abdullah R | 2013 | Research Journal of Applied Sciences Engineering and Technology2013，5，3： | 1 |
| 17 | Developing a multipm]pose sun tracking system using fuzzy control 显示文摘 | MOHANAD ALATA M A Al NIMSR YOUSEF QAROUSH | 2005 | Energy Conversion and Management2005，46，： | 1 |
| 18 | Update on dexmedetomidine: use in nonintubated patients requiring sedation for surgical procedures显示文摘 | Mohanad Shukry Jeffrey Miller | 2010 | 2010 (defa)2010，，： | 1 |
| 19 | Evaluation of the rheumatoid factors of the Ig G,Ig M and Ig A isotypes as prognostic parameters for rheumatoid arthritis among Iraqi patients显示文摘 | Ahmed Mohanad Obaid Al-Ruhaimi Khalid Mohammed Suhad | 2010 | Indian Journal of Pathology and Microbiology2010，53，3： | 1 |
| 20 | Management of the difficult pediatric airway with Shikani 显示文摘 | Mohanad S Ryan D Hanson JR | 2005 | Pediatric Anesthesia2005，15，4： | 1 |
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