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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | Synthesis, characterization and effect of reaction parameters on swelling properties of acrylamide-sodium methacrylate superabsorbent copolymers 显示文摘 | Mohan Y M Murthy P S K Raju K M | 2005 | Reactive & Functional Polymers2005，63，： | 1 |
| 3 | Preparation and swelling behavior of macroporous poly (acrylamide-co-sodium methacrylate) superabsorbent hydrogels显示文摘 | Mohan Y M Murthy P S K Raju K M | 2006 | Journal of Applied Polymer Science2006，101，5： | 1 |
| 4 | Design and fabrication of an automated technique: measurement of spontaneous polarization in two new schiff'base ferroelectric liquid crystals 显示文摘 | Madhu Mohan M L N Goud B V S Kumar P A | 1999 | Materials Research Bulletin1999，34，1415： | 1 |
| 5 | 显示文摘 | MOHAN C KUMAR V MAHAJAN M P | 2004 | Tetrahedron Lett2004，45，31： | 1 |
| 6 | Contractor selection for design build projects显示文摘 | EKAMBARAM P MOHAN M K | 2000 | Journal of Construction En- gineering and Management2000，126，5： | 1 |
| 7 | A compara- tive study of phase-shifting algorithms in digital speckle pattern interferometry 显示文摘 | Bhaduri B Kothiyal M P Mohan N K | 2008 | OPTIK2008，119，3： | 1 |
| 8 | Synthesis and characterization of GAP - PEG copolymers 显示文摘 | Mohan Y M Raju M P Raju K M | 2005 | International Journal of Polymeric Materials2005，54，7： | 1 |
| 9 | Vertical transmission of white spot baculovirus in shrimps-a possibility? 显示文摘 | Mohan C V Sudha P M Shankar K M | 1997 | Current Science1997，73，： | 1 |
| 10 | Studies on corrosion resistant properties of inhibitive primed IPN coating systems incomparison with epoxy-PU systems 显示文摘 | Krishnan S M Mohan P S | 2007 | Journal of Coat- ings Technology and Research2007，4，1： | 1 |
| 11 | Development of dense gas dispersion model for emergency preparedness 显示文摘 | Mohan M Panwar T S Singh M P | 1995 | Atmospheric Environment1995，29，16： | 1 |
| 12 | Development of dense gas diserpersion model for emergency preparedness显示文摘 | MOHAN Panwar T S Singh M P | 1995 | Atmospheric Environment1995，29，16： | 1 |
| 13 | Synthesis and water absorbency of crosslinked superabsorbent polymers显示文摘 | RAJU K M RAJU M P MOHAN Y M | 2002 | Journal of Applied Polymer Science2002，85，： | 1 |
| 14 | Design criteria and theoretical basis for capping contaminated marine sediments显示文摘 | Mohan R K Brown M P Barnes C R | 2000 | Applied Ocean Research2000，22，2： | 1 |
| 15 | A real co- ded genetic algorithm for solving integer and mixed inte- ger optimization problems显示文摘 | Deep K Singh K P Kansal M L Mohan C | 2009 | Applied Mathematics and Computation2009，212，2： | 1 |
| 16 | Prevalence of job strain among Indian foundry shop floor workers显示文摘 | MOHAN G M ELANGOVAN S KRISHNA P R | 2008 | IOS Press2008，30，4： | 1 |
| 17 | A retroperitoneal bleed induced by enoxaparin therapy显示文摘 | ERNITS M MOHAN P S FARES L G | 2005 | Am Surg2005，71，5： | 1 |
| 18 | Bandwidth extension in CMOS with optimized on-chip inductors显示文摘 | Mohan S S Hershenson M D M Boyd S P | 2000 | IEEE Journal of Solid-State Circuits2000，，： | 1 |
| 19 | Adsorptive removal of phthalate ester (di-ethyl phthalate) from aqueous phase by activated carbon: a kinetic study 显示文摘 | Venkata Mohan S Shailaja S Rama Krishna M Sarma P N | 2007 | Journal of Hazardous Materials2007，146，12： | 1 |
| 20 | Cystatin C rescues degenera- ting neurons in a cystatin B-knockout mouse model of progressive myeclonus epilepsy显示文摘 | Kaur G Mohan P Pawlik M | 2010 | Am J Pathol2010，177，： | 1 |
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