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您的检索式：作者名="Mohammed Awal Issah"
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| 1 | 罕见高白细胞T淋巴母细胞淋巴瘤/白血病伴PICALM-MLLT10融合、多基因突变一例显示文摘病例介绍患者,男,33岁,因“发现颜面部及右颈部浮肿2周”于2019年2月14日入我院(福建医科大学附属协和医院)。患者缘于入院前2周无明显诱因出现面部浮肿,以右侧明显,压之凹陷,伴右侧颈部浮肿,性质同上,伴少许干咳,当地医院查肺部CT示:①前上纵隔不规则形软组织密度占位,纵隔多发肿大淋巴结.考虑纵隔淋巴瘤,恶性可能,建议行CT增强检查;②右肺炎性感染可能;③右侧胸腔积液,右侧胸膜增厚。 | 刘彦权 沈建箴 张浪辉 付海英 陈伟鸿 谢水玲 Mohammed Awal Issah 周华蓉 | 2019 | 华西医学2019，34，12： | 2 |
| 2 | LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization显示文摘Objective YAP1 plays a dual role as an oncogene and tumor suppressor gene in several tumors;differentiating between these roles may depend on the YAP1 phosphorylation pattern.The specific function of YAP1 in B cell acute lymphoblastic leukemia(B-ALL),however,is currently unclear.Thus,in the present study,the role of YAP1 in B-ALL was investigated using relevant cell lines and patient datasets.Methods The effects of shRNA-mediated knockdown on YAP1 and LATS1 levels in the NALM6 and MOLT-4 cell lines were examined using Western blotting,quantitative real-time polymerase chain reaction,flow cytometry,immunostaining,and nude mouse subcutaneous tumorigenesis experiments.Gene expression levels of Hippo pathway-related molecules before and after verteporfin(VP)treatment were compared using RNA-Seq to identify significant Hippo pathway-related genes in NALM6 cells.Results Patients with ALL showing high YAP1 expression and low YAP1-Ser127 phosphorylation levels had worse prognoses than those with low YAP1 protein expression and high YAP1-Ser127 phosphorylation levels.YAP1-Ser127 phosphorylation levels were lower in NALM6 cells than in MOLT-4 and control cells;YAP1 was distributed in the nuclei in NALM6 cells.Knockdown of YAP1 inhibited MOLT-4 and NALM6 cell proliferation and arrested the NALM6 cell cycle in the G0/G1 phase.Before and after VP treatment,the expression of the upstream gene LATS1 was upregulated;its overexpression promoted YAP1-Ser127 phosphorylation.Further,YAP1 was distributed in the plasma.Conclusion LATS1 may downregulate YAP1-Ser127 phosphorylation and maintain B-ALL cell function;thus,VP,which targets this axis,may serve as a new therapeutic method for improving the outcomes for B-ALL patients. | Feng ZHANG Mohammed Awal Issah Hai-ying FU Hua-rong ZHOU Ting-bo LIU Jian-zhen SHEN | 2024 | Current Medical Science2024，44，1： | 0 |
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