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| 1 | Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy显示文摘Background:Parkinson’s disease(PD)is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms.PD is characterized by intraneuronal accumulation of abnormalα-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of eitherα-synuclein,as in the case of Multiple System Atrophy(MSA)or tau,as in the case of Corticobasal Degeneration(CBD)and Progressive Supranuclear Palsy(PSP),in other disease-specific brain regions.Definite diagnosis of all these diseases can be formulated only neuropathologically by detection and localization ofα-synuclein or tau aggregates in the brain.Compelling evidence suggests that trace-amount of these proteins can appear in peripheral tissues,including receptor neurons of the olfactory mucosa(OM).Methods:We have set and standardized the experimental conditions to extend the ultrasensitive Real Time Quaking Induced Conversion(RT-QuIC)assay for OM analysis.In particular,by using human recombinantα-synuclein as substrate of reaction,we have assessed the ability of OM collected from patients with clinical diagnoses of PD and MSA to induceα-synuclein aggregation,and compared their seeding ability to that of OM samples collected from patients with clinical diagnoses of CBD and PSP.Results:Our results showed that a significant percentage of MSA and PD samples inducedα-synuclein aggregation with high efficiency,but also few samples of patients with the clinical diagnosis of CBD and PSP caused the same effect.Notably,the final RT-QuIC aggregates obtained from MSA and PD samples owned peculiar biochemical and morphological features potentially enabling their discrimination.Conclusions:Our study provide the proof-of-concept that olfactory mucosa samples collected from patients with PD and MSA possess important seeding activities forα-synuclein.Additional studies are required for(i)estimating sensitivity and specificity of the technique and for(ii)evaluating its application for the diagnosis of PD and neurodegenerative parkinsonisms.RT-QuIC analyses of OM and cerebrospinal fluid(CSF)can be combined with the aim of increasing the overall diagnostic accuracy of these diseases,especially in the early stages. | Chiara Maria Giulia De Luca Antonio Emanuele Elia Sara Maria Portaleone Federico Angelo Cazzaniga Martina Rossi Edoardo Bistaffa Elena De Cecco Joanna Narkiewicz Giulia Salzano Olga Carletta Luigi Romito Grazia Devigili Paola Soliveri Pietro Tiraboschi Giuseppe Legname Fabrizio Tagliavini Roberto Eleopra Giorgio Giaccone Fabio Moda | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 2 | Hyperbaric oxygen therapy as a complementary treatment for radiation proctitis:Useless or useful?-A literature review显示文摘Radiotherapy(RT)is the backbone of multimodality treatment of more than half of cancer cases.Despite new modern RT techniques,late complications may occur such as radiation proctitis(RP).The natural history of RP is unpredictable.Minor symptoms may resolve spontaneously or require conservative treatment.On the other hand,for similar and uncomplicated clinical contexts,symptoms may persist and can even be refractory to the progressive increase in treatment measures.Over the last decades,an enormous therapeutic armamentarium has been considered in RP,including hyperbaric oxygen therapy(HBOT).Currently,the evidence regarding the impact of HBOT on RP and its benefits is conflicting.Additional prospective and randomised studies are necessary to validate HBOT’s effectiveness in the‘real world’clinical practice.This article reviewed the relevant literature on pathophysiology,clinical presentation,different classifications and discuss RP management including a proposal for a therapeutic algorithm with a focus on HBOT. | Diogo Alpuim Costa Carla Espiney Amaro Ana Nunes Joana Santos Cardoso Pedro Modas Daniel Isabel Rosa João Vieira Branco | 2021 | World Journal of Gastroenterology2021，27，27： | 4 |
| 3 | open reducation and internal fixation ofproximal humeral fracture and fracture-dislocatrion显示文摘 | Moda SK Chadha NS Sangwan SS | 1990 | J Bone Joint Surg(Br)1990，72，： | 1 |
| 4 | The zoonotic importance of Mycobacterium boris 显示文摘 | Moda G Daborm CJ | 1996 | Tuber Lung Dis1996，77，： | 1 |
| 5 | Coherent two-dimensional lasing action in surface-emitting laser with triangular-lattice photonic crystal structure显示文摘 | Imada M Moda S Chutinan A | 1999 | Appl Phys Lett1999，75，： | 1 |
| 6 | Gamma interferon assay for the diagnosis of bovine tuberculosis:field evaluation of sensitivity and specificity显示文摘 | Dondo A Goria M Moda G | 1996 | Medicina Veterinaria Preventiva1996，13，： | 1 |
| 7 | Open reduction and fixation of proximal humeral fractures and fracture-dislocations显示文摘 | Moda SK Chadha NS Sangwan SS | 1990 | J Bone Joint Surg Br1990，72，6： | 1 |
| 8 | The clinical utility of HPV DNA testingin cervical cancer screening strategies显示文摘 | Bhatal N Moda N | 2009 | Indian J Med Res2009，130，： | 1 |
| 9 | The zoonotic importance of Mycobacterium bovis 显示文摘 | Moda G Daborn CJ Grange 1M Cosivi O | 1996 | Tuber Lung Dis1996，77，2： | 1 |
| 10 | Open reduction and fixation of proximal humeral fractures and fracture-dislocations显示文摘 | Moda SK Chadha NS Sangwan SS | 1990 | J Bone Joint Surg(Br)1990，72，6： | 1 |
| 11 | Enamel microabrasion for aesthetic management of dental fluorosis 显示文摘 | Pandey P Ansari AA Moda P | 2013 | BMJ Case Rep2013，，20： | 1 |
| 12 | Risk factors forClostridium difficile-associated diarrhoea in HIV-infectedpatients 显示文摘 | Hutin Y Molina JM Casin I Daix V Sednaoui P WelkerYf Lagrange P Decazes JM Moda'i J | 1993 | AIDS1993，7，11： | 1 |
| 13 | AHM1, a novel type of nuclear matrix-localized, MAR binding protein with a single AT hook and a J domain-homologous region 显示文摘 | Morisawa G Han-yama A Moda I | 2000 | Plant Cell2000，12，10： | 1 |
| 14 | Non-technical constraints to eradication:The Italian experience显示文摘 | Giuliana Moda | | 0，，： | 1 |
| 15 | AHM1, a novel type of nuclear matrix - localized, MAR binding protein with a single AT hook and a J domain - homologous region显示文摘 | Morisawa G Han-yama A Moda I | 2000 | Plant Cell2000，12，10： | 1 |
| 16 | Open reducation and fixation of proximal humeral fractures and fractures-dislocations显示文摘 | Moda SK Chadha NS Sangwan SS | 1990 | J Bone Joint Surg Br1990，72，6： | 1 |
| 17 | Effects of high sodium chloride concentrations on activated sludge treatment 显示文摘 | MODA M F AL-ATTAR I M S | 1995 | Water Sci Technol1995，31，9： | 1 |
| 18 | Comparative study of chemoradiation and neoadjuvant chemotherapy effects before radical hysterectomy in stage ⅠB-ⅡB bulky cervical cancer and with tuner diameter greater than 4 cm显示文摘 | Modaness M Maghami FQ Golnavaz M | 2005 | Int J Gynecol Cancer2005，15，3： | 1 |
| 19 | The clinical utility of HPV DNA testing in cervical cancer screening strategies 显示文摘 | Bhatla N Moda N | 2009 | Indian J Med Res2009，130，3： | 1 |
| 20 | The zoonotic importance of Mycobacterium bovis显示文摘 | MODA G DABORM C J | 1996 | Tuber Lung Dis1996，7，7： | 1 |
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