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36篇 您的检索式：作者名="Mitev"

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	题名	作者	年代	出处	被引量
1	Production of 5-amino-8-hydroxyquinoline and some of its derivatives显示文摘	Markov K Markova N Mitev S	1977	Sofia1977，22，1：	2
2	Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family显示文摘AIM: To present novel frameshift mutation c.31delC [p.L11X] in the MLH1 gene identified in an extended Bulgarian hereditary non-polyposis colorectal cancer (HNPCC) family and to analyze the molecular and clinical findings within the pedigree concerning the proposal of adequate individual prophylactic strategy for all mutation carriers. METHODS: The pedigree of the family consists of 42 members in four generations. Search for mutations in the MLH1 and hMSH2 genes was performed in the pro-band. After PCR amplification of all exons including flanking intronic regions, amplicons were directly sequenced. RESULTS: The mutation was found in nine from the thirteen pedigree members who signed informed consent to participate in the study. In three adenocarcinomas, microsatellite instability and lack of the MLH1 protein expression were detected. The only one tubulovillous adenoma analyzed was microsatellite stable and the MLH1 protein showed an intact staining. CONCLUSION: The newly described mutation c.31delC is HNPCC causative. Besides the typical clinical features of the syndrome, we found a specific pathologic manifestation such as moderate to high differentiated adenocarcinomas of the colon. One of the mutation carriers developed a benign giant cell soft tissue tumor. The primary tumor localizations were frequently extracolonic and detailed yearly gastrointestinal and gynecological examinations have been proposed to the mutation carriers. We emphasize the importance of including the HNPCC genetic counseling and testing as well in the following surveillance of all patients at risk in the services covered by the health insurance in Bulgaria.	Tanya Kirilova Kadiyska Radka Petrova Kaneva Dimitar Georgiev Nedin Alexandrina Borisova Alexandrova Antonina Todorova Gegova Stoyan Ganchev Lalchev Tatyana Christova Vanio Ivanov Mitev Juergen Horst Nadja Bogdanova Ivo Marinov Kremensky	2006	World Journal of Gastroenterology2006，12，48：	2
3	Chronic melatonin treatment counteracts glucocrticoid-induced dysregulation of hypothalamo-pituiary-adrenal axis in the rat 显示文摘	Konakchieva R Mitev Y Almeida OF	1998	Neuroendocrinology1998，67，3：	1
4	Experimental investigation of high-power single-pass Raman shifters in the ultraviolet with Nd:YAG and KrF lasers显示文摘	Sonoulepnikoff L D Mitev V Simeonov V	1997	Appl Opt1997，36，21：	1
5	Business process re-engineer-ing:A critical appraisal显示文摘	Grey C and Mitev N N	2005	PersonnelReview2005，，1：	1
6	Effect of body condition score at calving on 305-day and test-day milk yield in Holstein-Friesian and Brown Swiss cows显示文摘	Gergovska Z Mitev J Angelova T	2012	J Fac Vet Med Istanbul Univ2012，38，2：	1
7	Pseudo-random noise-continuous-wave laser radar for surface and cloud measurements显示文摘	Matthey R Mitev V	2005	Optics and Lasers in Engineering2005，43，35：	1
8	Chronic melatonin treatment counteracts glucocorticoid-induced dysregulation of the hypothalamic-pituitary-adrenal axis in the rat 显示文摘	Konakchieva R Mitev Y Almeida OF	1998	Neuroendocrinology1998，67，3：	1
9	Effect of lameness on pro- ductive traits and health status of cows in dairy cattle farms显示文摘	Mitev J Penev T Vasilev N	2012	Trakia Journal of Sciences2012，10，1：	1
10	Simultaneous analysis of amino acid and biogenic polyamines by high-performance liquid chromatography after pre-column derivatization with N- (9-?uorenylmethoxycar- bonyloxy)succinimide显示文摘	LOZANOV V PETROV S MITEV V	2004	J Chromatogr A2004，1025，2：	1
11	Elevated aerosol stratification above rhine valley under strong anticyclonic conditions 显示文摘	FRIOUD M MITEV V MATTHEY R	2003	Atmosphere Environment2003，37，13：	1
12	Experimental inversgafion of high - power single- pass Raman shifters in the ultraviolet with Nd:YAG and KrF lasers显示文摘	Laurent de Schoulepnikoff Valentin Mitev	1997	Applied Optics1997，，36：	1
13	Experimental investigation of high-power single-pass Raman shifters int the ultraviolet with Nd:YAG and KrF lasers显示文摘	Laurent de SONOULEPNIKOFF Vaientin MITEV Valentin SIMEONOV	1997	Applied Optics1997，36，21：	1
14	Pseudo-random noise-continuous-wave laser radar for surface and cloud measurements 显示文摘	Matthey R Mitev V	2004	Optics and Lasers in Engineering2004，43，：	1
15	Pseudo-random noise-continuous-wave laser radar for surface and cloud measurements显示文摘	Matthey R Mitev V	2005	Optics and Lasers in Engineering2005，43，：	1
16	Raman frequency shifting in a CH4 : H2 : Ar mixture pumped by the fourth harmonic of a Nd:YAG laser显示文摘	Valentin Simeonov Valentin Mitev	1998	Applied Optics1998，，37：	1
17	Chronic melatonin treatment counteracts glucocorticoid-induced dysregulation of the hypothalamic-pituitary-adrenal axis in the rat显示文摘	Konakchieva R Mitev Y Almeida OF	1998	Neuroendocrinology1998，67，3：	1
18	Chronic melatonin treatment and the Hypothalamo-Pituitary-Adreaal axis in the rat: attenuation of the secretory response to stress and effects on hypothalamic neuropeptide content and release显示文摘	Konakchieva R Mitev Y Almeida O F	1997	Biol Cell1997，89，9：	1
19	Liquid chromatography method for simultaneous analysis of amino acids and biogenic amines in biological fluids with simultaneous gradient of pH and acetonitrile显示文摘	Valentin Lozanov Bistra Benkova Lyudmila Mateva Stefan Petrov Elenko Popov Chavdar Slavov Vanio Mitev	2007	Journal of Chromatography B2007，，1：	1
20	The small Rho GTPase Rac 1 controls normal human dermal fibroblasts prolifferation with phosphorylation of the oncoprotein c-myc显示文摘	Nikolova E Mitev V Zhelev N	2007	Biochemical and Biophysical Research Communications2007，359，3：	1

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