|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 2 | Chemical shift phase-difference and suppression magnetic resonance imaging techniques in animals, phantoms, and humans显示文摘 | Mitchell DG Kim I Chang TS | 1991 | Investigative Radiology1991，26，12： | 2 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Two faces: Effects of business groups on innovation in emerging economies 显示文摘 | Mahmood I P Mitchell W | 2004 | MANAGEMENT SCI- ENCE2004，50，10： | 1 |
| 5 | Endovascular management vein of galen aneursmal malformations presenting in the veonatal perisd显示文摘 | Peter J Mitchel I Jeffrey V | 2001 | American Journal of Neuroradiology2001，22，： | 1 |
| 6 | Effect of intrusion detection and responseon reliability of cyber physical systems显示文摘 | Mitchell R Chen I R | 2013 | IEEE Transactions onReliability2013，62，： | 1 |
| 7 | Nonfunctionalized nanocrystals can exploit a cells active transport machinery delivering them to specific nuclear and cytoplasmic compartments显示文摘 | Nabiev I Mitchell S Davies A | 2007 | Nano Lett2007，7，11： | 1 |
| 8 | Methanogenesis in the sediments of an Australian freshwater wetland:Comparison with aerobic decay,and factors controlling methanogenesis显示文摘 | Mitchell P I B | 1995 | Fems Micriobiology Ecology1995，18，3： | 1 |
| 9 | Anti-tuberculous therapy and a cute liver failure显示文摘 | Mitchell I Wendon J Fitt S | 1995 | Lancet1995，345，： | 1 |
| 10 | In Situ Biodeposition Rates of Pacific Oysters (Crassostrea Gigas) on a Marine Farm in Southern Tasmania (Australia)显示文摘 | MITCHELL I M | 2006 | Aquaculture2006，257，： | 1 |
| 11 | Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells 显示文摘 | Afzali B Mitchell P Lechler R I | 2010 | Clin Exp Immunol2010，159，2： | 1 |
| 12 | Transfor- ming growth factor beta inhibitory element in the rabbitmatrix met- alloprote inase - 1 ( collagenase - 1 ) gene functions as a repressor of constitutive transcription 显示文摘 | WHITE I A MITCHELL T I BRINCKERHOFF C E | 2000 | Biophys Acta2000，1490，3： | 1 |
| 13 | Pharmacological management of no reflow during percutaneous coronary intervention显示文摘 | Porto I Ashar V Mitchell ARJ | 2006 | Current Vascular Pharmacology2006，4，3： | 1 |
| 14 | Diabetic autonomicneuropathy显示文摘 | VINIK A I MASER R E MITCHELL B D | 2003 | Diabetes Care2003，26，5： | 1 |
| 15 | Chemical composition of hyphal and sclerotial walls of Sclerotium rolfsii Sacc显示文摘 | Chet I Henis Y Mitchell R | 1967 | Can J Microbiol1967，13，2： | 1 |
| 16 | Finite element methods for second order differential equations with significant first derivatives显示文摘 | CHRISTIE I GRIFFITHS D F MITCHELL A R | 1976 | International Journal for Numerical Methods in Engineering1976，10，6： | 1 |
| 17 | Further studies on the chemical control of feeding behaviour in the dove sole,solea solea 显示文摘 | Mackie A M Mitchell A I | 1982 | Comparative Biochemistry and Physiology1982，73，： | 1 |
| 18 | CARESS: The Canadianregistry of palivizumab显示文摘 | Mitchell I Paes BA Li A | 2011 | Pediatr Infect Dis J2011，30，8： | 1 |
| 19 | Trends in thy- roid cancer demographics and surgical therapy in the United States 显示文摘 | Mitchell I Livingston EH Chang AY | 2007 | Surgery2007，142，6： | 1 |
| 20 | Prenatal cigarette smoke exposure attenuates recovery from hypoxemic challenge in preterm ilrfants 显示文摘 | Schneider J Mitchell I Singhal N | 2008 | Am J Respir Crit Care Med2008，178，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员