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| 1 | Chronic atrophic gastritis detection with a convolutional neural network considering stomach regions显示文摘BACKGROUND The risk of gastric cancer increases in patients with Helicobacter pylori-associated chronic atrophic gastritis(CAG).X-ray examination can evaluate the condition of the stomach,and it can be used for gastric cancer mass screening.However,skilled doctors for interpretation of X-ray examination are decreasing due to the diverse of inspections.AIM To evaluate the effectiveness of stomach regions that are automatically estimated by a deep learning-based model for CAG detection.METHODS We used 815 gastric X-ray images(GXIs)obtained from 815 subjects.The ground truth of this study was the diagnostic results in X-ray and endoscopic examinations.For a part of GXIs for training,the stomach regions are manually annotated.A model for automatic estimation of the stomach regions is trained with the GXIs.For the rest of them,the stomach regions are automatically estimated.Finally,a model for automatic CAG detection is trained with all GXIs for training.RESULTS In the case that the stomach regions were manually annotated for only 10 GXIs and 30 GXIs,the harmonic mean of sensitivity and specificity of CAG detection were 0.955±0.002 and 0.963±0.004,respectively.CONCLUSION By estimating stomach regions automatically,our method contributes to the reduction of the workload of manual annotation and the accurate detection of the CAG. | Misaki Kanai Ren Togo Takahiro Ogawa Miki Haseyama | 2020 | World Journal of Gastroenterology2020，26，25： | 17 |
| 2 | Recovery of rare-earth metal neodymium from aqueous solutions by poly-γ-glutamic acid and its sodium salt as biosorbents:Effects of solution pH on neodymium recovery mechanisms显示文摘For recovery of metals from low-concentration sources, biosorption is one of promising technologies and poly-γ-glutamic acid(γ-PGA) has been known as a potential biosorbent for recovery of heavy metals from aqueous solutions. Effects of solution pH on recovery of rare-earth metal Nd are systematically examined to clarify mechanisms of Nd recovery by y-PGA and its sodium salt(y-PGANa). The recovery efficiency of Nd by y-PGA increases from 2.4 to 19.6% as pH increases from 2 to 4. Subsequently the Nd recovery efficiencies for y-PGA and y-PGANa remain almost constant in the range of pH from 4 to 7. For pH > 7 the increase in Nd recovery is significant and 100% recovery of Nd is achieved at pH 9. The pH dependency on Nd recovery by y-PGANa is similar to that by y-PGA. Contributions of adsorption and precipitation/coagulation to Nd recovery process are quantified. Whereas the adsorption dominates Nd recovery at lower pH(<~4), the precipitation/coagulation controls Nd recovery process for pH > 7. At higher pH, purple gel precipitates are observed. The maximum adsorption capacities for γ-PGA and yPGANa are 215 mg-Nd/(g-γ-PGA) at pH 4 and 305 mg-Nd/(g-y-PGANa) at pH 3, respectively. From the spectra of FT-IR and XPS, the biosorption of Nd onto y-PGA and y-PGANa via electrostatic interaction with carboxylate anions at pH 3 is verified. The Nd complexation with amide and carboxylate anion groups on γ-PGA and γ-PGANa may also contribute to the Nd recovery. The biosorption isotherms for Nd recovery by γ-PGA and γ-PGANa can be satisfactorily fitted by the Langmuir model. The thermodynamic studies suggest that the biosorptions of Nd by γ-PGA and γ-PGANa are endothermic. The utilization of γ-PGA and γ-PGANa as potential and eco-friendly biosorbents for the highly effective recovery of Nd from aqueous solution is confirmed. | Misaki Hisada Yoshinori Kawase | 2018 | Journal of Rare Earths2018，36，5： | 5 |
| 3 | Establishment and characterization of a breast cancer cell line expressing Na+/I-symporter for radioiodide concentrator gene therapy显示文摘 | Nakamato Y Saga T Misaki T | 2000 | J Nucl Med2000，41，： | 2 |
| 4 | Granulocyte colony-stimulating factor-producing squamous cell carcinoma of the tongue exhibiting characteristic fluorine-18 deoxyglucose accumulation on positron emission tomography–computed tomography: A case report显示文摘BACKGROUND Granulocyte colony-stimulating factor(G-CSF)is a cytokine produced in inflammatory environments that induces differentiation and proliferation of neutrophils in bone marrow.We report a rare case of aggressive G-CSFproducing squamous cell carcinoma of the tongue exhibiting fluorine-18 deoxyglucose(FDG)accumulation in primary lesion,metastatic lymph nodes,spleen,and bone marrow on positron emission tomography–computed tomography(PET/CT).CASE SUMMARY We report a 58-year-old female with a rapid enlarged lingual mass with partial necrosis.Blood test results from the initial examination revealed a leukocyte count of 21380/μL.On PET/CT,extensive FDG accumulation was observed in the tongue and bilateral cervical lymph nodes,with elevated FDG accumulation in the spleen and bone marrow although no distant metastases were observed.We performed partial glossectomy and bilateral neck dissection.Immunohistochemical staining with G-CSF antibodies on biopsy specimen and resected samples revealed that both specimens were G-CSF positive.This is a rare case of G-CSF producing tongue carcinoma with elevated FDG accumulation in the spleen and bone marrow.CONCLUSION In patients with the tongue cancer and hyperleukocytosis,where FDG accumulations in the spleen and bone marrow are observed using PET/CT and when these accumulations are not caused by metastasis,G-CSF-producing tumors,with associated poor prognosis,should be considered. | Hiroaki Shimamoto Yuka Hirota Yoshihisa Kashima Naoya Kinoshita Misaki Yokokawa Tohru Ikeda Hiroyuki Harada | 2020 | World Journal of Clinical Cases2020，8，9： | 2 |
| 5 | Studies on interrelation of structure and antitumor effects of polysaccharides: antitumor action of periodate-modificd, branched (1→3)-β-D-glucan of Auricularia auricula-judae, and other polysaccharides containing (1→3)-glycosidic linkages显示文摘 | Misaki A Kakuta M | 1981 | Carbohytdr Res1981，92，： | 1 |
| 6 | The water detritiation system of the ITER tritium plant显示文摘 | Iwai Y Misaki Y Hayashi T | 2002 | Fusion Science and Technology2002，41，： | 1 |
| 7 | Scar tissue distribution on palates and its relation to maxillary dental arch form显示文摘 | Ishikawa H Nakamura S Misaki K | 1998 | Cleft Palate Craniofac J1998，35，3： | 1 |
| 8 | Formation of single-crystal-like poly(9,9-dioctylfluorene) thin film by the friction-transfer technique with subsequent thermal treatments显示文摘 | Misaki M Ueda Y Nagamatsu S | 2004 | Macromolecules2004，37，18： | 1 |
| 9 | Side-chain effects on friction-transferred polymer orientation显示文摘 | Nagamatsu S Misaki M Kimura T | 2007 | Polymer Journal2007，39，12： | 1 |
| 10 | The Water Detritiation System of the ETER Tritium Plant 显示文摘 | Iwai Y Misaki Y | 2002 | Fusion Sei Teehnol2002，41，： | 1 |
| 11 | Scar tissue distribution on palates and its relation to maxillary dental arch form显示文摘 | Nakamura S Misaki K | 1998 | Cleft Palate Craniofac J1998，35，： | 1 |
| 12 | Isolation and characterization of polysaccharides of kikurgae fruit body of Auricularia auricula-judae显示文摘 | Sone Y Kakuta M Misaki A | 1978 | Agricultural Biology and Chemistry1978，42，2： | 1 |
| 13 | Methylthiosubstituted 2, 5-bis ( 1', 3'- dithiol-2'-ylidene )- 1, 3, 4, 6-tetrathiapentalene 显示文摘 | Misaki Y Nishikawa H Kawakami K | 1992 | Chemistry Letters1992，，： | 1 |
| 14 | Ero- sion of gastric mucosa-pathogenesis, incidence and classification of the erosive gastritis 显示文摘 | KAKAI K SHIMAMOTO K MISAKI F | 1970 | Endoscopy1970，2，3： | 1 |
| 15 | Supernatant protein factor,which stimulates the conversion of squalene to lanosterol,is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis显示文摘 | Shibata N Arita M Misaki Y | | 0，，： | 1 |
| 16 | Clinical effect of combination therapy of pioglitazone and an alpha-glucosidase inhibitor显示文摘 | Seino H Yamaguchi H Misaki A | 2003 | Curr Med Res Opin2003，19，8： | 1 |
| 17 | Polysaccharide of Junsai(Brasenia schreberi J F Gmel)Mucilage:Constitution and Linkage Analysis显示文摘 | KAKUTA M MISAKI A | 1979 | Aric Boil Chem1979，43，5： | 1 |
| 18 | Immunologic identification of lymphocyte subsets in murine Coxsacdievirus B3 myocarditis: different kinetics and significance of lymphocyte subsets in the heart and in peripheral blood显示文摘 | Kishimoto C Misaki T Crumpacker SC | 1988 | Circulation1988，77，3： | 1 |
| 19 | Possiblemechanism of gastric mucosal protection by epidermalgrowth factor in rats显示文摘 | Amagase H Murakami T Misaki M | 1990 | Life Sci1990，47，14： | 1 |
| 20 | Telomerase activity and p53 expression in pterygia显示文摘 | Sbigeto S Misaki I Kazuomi H | 2000 | Invest Ophthalmol Vis Sci2000，41，6： | 1 |
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