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| 1 | Utilizing gastric cancer organoids to assess tumor biology and personalize medicine显示文摘While the incidence and mortality of gastric cancer (GC) have declined due to public health programs, it remains the third deadliest cancer worldwide. For patients with early disease, innovative endoscopic and complex surgical techniques have improved survival. However, for patients with advanced disease, there are limited treatment options and survival remains poor. Therefore, there is an urgent need for more effective therapies. Since novel therapies require extensive preclinical testing prior to human trials, it is important to identify methods to expedite this process. Traditional cancer models are restricted by the inability to accurately recapitulate the primary human tumor, exorbitant costs, and the requirement for extended periods of development time. An emerging in vitro model to study human disease is the patient-derived organoid, which is a three-dimensional system created from fresh surgical or biopsy tissues of a patient’s gastric tumor. Organoids are cultured in plastic wells and suspended in a gelatinous matrix, providing a substrate for extension and growth in all dimensions. They are rapid-growing and highly representative of the molecular landscape, histology, and morphology of the various subtypes of GC. Organoids uniquely model tumor initiation and growth, including steps taken by normal stomach cells to transform into invasive, intestinal-type tumor cells. Additionally, they provide ample material for biobanking and screening novel therapies. Lastly, organoids are a promising model for personalized therapy and warrant further investigation in drug sensitivity studies for GC patients. | Miranda Lin Mei Gao Michael J Cavnar Joseph Kim | 2019 | World Journal of Gastrointestinal Oncology2019，11，7： | 7 |
| 2 | Students of Different Minds: Bridging the Gaps of International Students Studying in the US显示文摘 | Miranda Lin | 2012 | US-China Education Review(A)2012，2，3： | 2 |
| 3 | Evaluation of equivalent linear methods for estimating target displacements of existing structures显示文摘 | Lin Yuyuan Eduardo Miranda | 2009 | Engineering Structures2009，31，4： | 1 |
| 4 | Anaplastic large cell lymphoma involving the breast: a clinicopathologic study of 6 cases and review of the literature显示文摘 | Miranda RN Lin L Talwalkar SS | 2009 | Arch Pathol Lab Med2009，133，9： | 1 |
| 5 | Seismic history analysis of asymmetric buildings with soil-structure interaction显示文摘 | Jui-Liang Lin Keh-Chyuan Tsai Eduardo Miranda | 2009 | Journal of Structural Engineering ASCE2009，135，2： | 1 |
| 6 | Noniterative equivalent linear method for evaluation of existing structures 显示文摘 | LIN Y Y MIRANDA E | 2008 | Journal of Structural Engineering2008，134，11： | 1 |
| 7 | Evaluation of damping reduction factors for estimating elastic response of structures with high damping显示文摘 | Lin Y Y Miranda E Chun Chang K C | 2005 | Earthquake Engineering and Structural Dynamics2005，34，11： | 1 |
| 8 | Noniterative equivalent linear method for evaluation of existing structures 显示文摘 | Lin Y Y Miranda E | 2008 | Journal of Structural Engineering2008，134，11： | 1 |
| 9 | Evaluation of damping reduction factors for estimating elastic response of structures with high damping 显示文摘 | Lin Y Y Miranda E Chang K C | 2005 | Earthquake Engineering and Structural Dynamics2005，34，1： | 1 |
| 10 | Estimation of maximum roof displacement demands in regular multistory building 显示文摘 | LIN Y Y MIRANDA E | 2010 | Journal of Engineering Mechanics2010，136，1： | 1 |
| 11 | Noniterative equivalent linear method for evaluation of existing structures 显示文摘 | Lin Y Y Miranda E | 2008 | Journal of Structural Engineering2008，134，11： | 1 |
| 12 | Seismic history analysis of asymmetric buildings with soil-structure interaction显示文摘 | Lin J L Tsai K C Miranda E | | 0，，02： | 1 |
| 13 | Treatment Effects of Acupuncture and Calligraphy Training on Cognitive Abilities in Senile Demented Patients显示文摘Purpose:This study compared the relative effectiveness of Chinese calligraphy handwriting(CCH)and acupuncture in the treatment of patients with senile dementia.Materials and Methods:A randomized controlled trial(RCT)with 17 mild-to-moderate dementia patients with an average age of 77.29 years were randomly assigned with 9 to the calligraphy handwriting group and 8 to the acupuncture treatment group for a month of consecutive treatment.The participants'cognitive abilities,as well as symptoms of senile dementia,were measured by the Chinese version of the Mini-mental State Examination(CMMSE)and the Chinese Medicine Quantitative Diagnostic Survey for Senile Dementia Symptoms,respectively,before and after the treatment.Results:The calligraphy group showed a significant increase in calculation and memory as well as a decline in the symptoms of senile dementia.Patients in the acupuncture group experienced a significant growth in total CMMSE scores and the subscales in orientation to time and place,behavioral operations,as well as reduced clinical symptoms.However,no significant changes were found in their memory and calculation abilities.Conclusion:Both CCH and acupuncture treatments were found significantly effective for,respectively,enhancing the patients'cognitive abilities and reducing their clinical symptoms.Further,calligraphy handwriting also improved the level of their attention and concentration,physical relaxation,and emotional stability. | Henry S.R.Kao Miqu Wang Shuguang Yu Shihong Yuan Miranda MY Fung Lin Zhu Stewart P.W.Lam Tin Tin Kao Xiaoyang Kao | 2019 | Chinese Medicine and Culture2019，2，2： | 1 |
| 14 | Anaplastic large cell lymphoma involving the breast:a clinicopathologic study of 6 cases and review of the literature显示文摘 | Miranda RN Lin L Talwalkar SS | 2009 | Arch Pathol Lab Med2009，133，9： | 1 |
| 15 | 子痫前期患者脐带血循环内皮细胞集落形成细胞水平降低显示文摘子痫前期是一种与后代心血管危险因素增加有关的妊娠相关性疾病。内皮细胞集落形成细胞(endo-thelialcolony-formingcells,ECFCs)是生长过程中参与血管形成的循环内皮祖细胞的一部分。然而,子痫前期对于胎儿ECFCs水平的影响尚未知。 | 刘莉 叶鹏 Muoz-Hernandez R Miranda ML Stiefel P Lin RZ Praena-Fernández JM Dominguez-Simeon MJ Villar J Moreno-Luna R Melero-Martin JM | 2014 | 中华高血压杂志2014，22，5： | 0 |
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