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| 1 | Acute infectious osteomyelitis in children: new treatment strategies for an old enemy显示文摘Background Acute osteomyelitis still represents a significant clinical challenge,with an increasing incidence in paediatric population.A careful assessment and a rapid diagnosis with proper timing and choice of empirical antimicrobial therapy are necessary to avoid sequelae.The initial treatment should consist of empirical antibiotic therapy,to cover the major responsible pathogens in each age group.Data sources We made a literature search with PubMed and Cochrane database from 2000 to 2019 in English,French,and Spanish languages using the key words'osteomyelitis,children,clinical,diagnosis,and treatment'.Results The child's clinical features,age,and the microbiological profile of the geographic area should be evaluated for diagnosis and in the choice of antibiotic treatment.Latest data suggest the administration of intravenous antibiotics for a short period,with subsequent oral therapy,according to the improvement of clinical status and inflammatory markers.For children older than 3 months,the shift to oral medications is already possible after a short course of intravenous therapy,until recovery.The timing for the shift from cefazolin to cephalexin or cefuroxime,intravenous clindamycin to oral clindamycin,and intravenous ceftriaxone+oxacillin to oral equivalents will be decided according to the improvement of clinical status and inflammatory markers.We also present the approach to osteomyelitis due to difficult pathogens,such as Methicillin-resistant Staphylococcus aureus(MRSA)and Panton-Valentine leukocidin(PVL)-positive S.aureus infections.Conclusion In this review,we present the current approach to the clinical diagnosis and management of osteomyelitis in childhood,with an update on recent recommendations,as a useful instrument to understand the rationale of antibiotic therapy. | Sabrina Congedi Chiara Minotti Carlo Giaquinto Liviana Da Dalt Daniele Don | 2020 | World Journal of Pediatrics2020，16，5： | 8 |
| 2 | The secondary alcohol metabolite of doxorubicin irreversibly inactivates conitase iron regulatory protein 1 in cytosolic fractions from human my ocardium显示文摘 | Minotti G Recalcati S Mo rdente A | 1998 | FA SEB J1998，12，7： | 1 |
| 3 | Ictal clinical and scalp- EEG findings differentiating temporal lobe epilepsies from temporal 'plus' epilepsies显示文摘 | Barba C Barbati G Minotti L | 2007 | Brain2007，130，： | 1 |
| 4 | Ictal clinical and scalp- EEG findings differentiating temporal lobe epilepsies from temporal ' plus' epilepsies显示文摘 | Barba C Barbati G Minotti L | 2007 | Brain2007，130，： | 1 |
| 5 | Anthracycline cardiotoxicity in breast cancer patients: synergism with trastuzumab and taxanes 显示文摘 | Gianni L Salvatorelli E Minotti G | 2007 | Cardiovasc Toxicol2007，7，2： | 1 |
| 6 | Field chlorophyll measurements to assess the nitrogen status of potato varieties显示文摘 | Minotti P L Halseth D E Sieczka J B | 1994 | HortScince1994，29，12： | 1 |
| 7 | Safety and usefulness of insular depth electrodes implanted via an oblique approach in patients with epilepsy显示文摘 | Afif A Chabardes S Minotti L | 2008 | Neurosurgery2008，62，52： | 1 |
| 8 | Field chlorophyll measurements to asses the nitrogen status of potato varieties 显示文摘 | Minotti P L Halseth D E Sieczka J B | 1994 | Hort Sci1994，29，12： | 1 |
| 9 | Design and optimization of batch-fabricated rotative piezomotors 显示文摘 | Le Moal P Minotti P Ferreira A Cusin P | 1996 | Smart Structures and Materials1996，，： | 1 |
| 10 | High-performance load-adaptive speed control for ultrasonic motors 显示文摘 | Ferreira A Minotti P | 1998 | Control Engineering Practice1998，6，1： | 1 |
| 11 | Diurnal variation in the nitrate concentration of beets 显示文摘 | Minotti P L Stankey D L | 1973 | Hortscience1973，8，： | 1 |
| 12 | Anthracyclines:molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity显示文摘 | Minotti G Menna P Salvatorelli E | 2004 | Pharmacol Rev2004，56，： | 1 |
| 13 | Age-dependency and dietary influence on the hypothalamic ouabain-like factor in Milan hypertensive rats 显示文摘 | Ferrandi M Minotti E Florio M | 1995 | J Hypertens1995，13，122： | 1 |
| 14 | Nitrate uptake by wheat as influenced by ammonium and other cations显示文摘 | Minotti P L Williams D C Jackson W A | 1969 | Crop Science1969，9，： | 1 |
| 15 | Antimicrobial activity of triantibiotic paste, 2% chlorhexidine gel,and calcium hydroxide on an intraoral-infected dentin biofilm model显示文摘 | Ordinola-Zapata R Bramante CM Minotti PG Cavenago BC Garcia RB Bemardineli N | 2013 | Journal of endodontics2013，39，1： | 1 |
| 16 | Aberrant phenotypic expression of CD15and CD56identifies poor prognostic acute promyelocytic leukemia patients显示文摘 | Breccia M De Propris Minotti C | 2014 | Leuk Res2014，38，2： | 1 |
| 17 | A phase Ⅱ trial of combined chemotherapy and surgery in stage ⅢA non-small cell lung cancer显示文摘 | Darwisk S Minotti V Criro L | 1995 | Lung Cancer1995，121，： | 1 |
| 18 | Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity 显示文摘 | Minotti G Menna P Salvatorelli E | 2004 | Pharmacol Rev2004，56，2： | 1 |
| 19 | Nitrate accumulation in vegetables显示文摘 | MAYNARD DN BARKER AV MINOTTI PL | 1976 | Adv Agron1976，28，： | 1 |
| 20 | Anthracyclines:molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity显示文摘 | Minotti G Menna P Salvatorelli E | 2004 | Pharmacol Rev2004，56，2： | 1 |
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