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| 1 | Inflammation-associated microsatellite alterations:Mechanisms and significance in the prognosis of patients with colorectal cancer显示文摘Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair(MMR). About 15% of sporadic colorectal cancers(CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono-and di-nucleotide frameshifts to classify it as microsatellite instability-high(MSI-H) and hypermutated, and due to frameshifts at coding microsatellites generating neo-antigens, produce a robust protective immune response that can be enhanced with immune checkpoint blockade. More commonly, approximately 50% of sporadic nonMSI-H CRCs demonstrate frameshifts at di-and tetra-nucleotide microsatellites to classify it as MSIlow/elevated microsatellite alterations at selected tetranucleotide repeats(EMAST) as a result of functional somatic inactivation of the DNA MMR protein MSH3 via a nuclear-to-cytosolic displacement. The trigger for MSH3 displacement appears to be inflammation and/or oxidative stress, and unlike MSI-H CRC patients, patients with MSI-L/EMAST CRCs show poor prognosis. These inflammatory-associated microsatellite alterations are a consequence of the local tumor microenvironment, and in theory, if the microenvironment is manipulated to lower inflammation, the microsatellite alterations and MSH3 dysfunction should be corrected. Here we describe the mechanisms and significance of inflammatory-associated microsatellite alterations, and propose three areas to deeply explore the consequences and prevention of inflammation's effect upon the DNA MMR system. | Minoru Koi Stephanie S Tseng-Rogenski John M Carethers | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 7 |
| 2 | A NEW FLAVONE C-GLYCOSIDE FROM SCUTELLARIA BAICALENSIS显示文摘ANEWFLAVONEC-GLYCOSIDEFROMSCUTELLARIABAICALENSIS￥YongYuZHANG;XianLI;YunZhenGOU(ShenyangPharmaceuticalUniversity,Shenyang11001... | Yong Yu ZHANG Xian LI Yun Zhen GOU(Shenyang Pharmaceutical University, Shenyang 110015)Yoshihiro HARIGAYA, Masayuki ONDASchool of Pharmaceutical Sciences, Kitasato University, Tokyo 108 ,JapanKadsunort H^SHIMO’rO, yukinobu iK EYA, Minoru OKAD^, cacao M^ | 1994 | Chinese Chemical Letters1994，5，10： | 3 |
| 3 | Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes显示文摘 | Minoru I Eisuke M Masao Y | 2005 | Metab Clin Exp2005，54，3： | 1 |
| 4 | Railroad noise in an open space显示文摘 | RUFIN M MINORU Y | | Applied Acoustics0，49，4： | 1 |
| 5 | Railroad Noise in an Open Space显示文摘 | Rufin M Minoru Y | 1996 | Applied Acoustics1996，49，4： | 1 |
| 6 | Development of the electronic instrument transformers for intelligent substation显示文摘 | Minoru S Kazuo K Yasuhiro M | 2003 | TMT&D Review2003，1，1： | 1 |
| 7 | Improved preserva- tion of function during acoustic neuroma surgery 显示文摘 | Hirofumi N Hidemi M Minoru T | 2015 | Jour- nal of Neurosurgery2015，122，1： | 1 |
| 8 | Application of the interseptal alveolotomy for closing the oroantral fistula 显示文摘 | Minoru H Hiroshi T Mistuhiko M | 1995 | Oral MaxillofacSurg1995，53，1： | 1 |
| 9 | Bacillus thuringiensis:A common member of microflora in activated sludges of a sewage treatment plant显示文摘 | EIICHI M MINORU M RIE T | 2001 | Current Microbiology2001，42，6： | 1 |
| 10 | Paradisin C:a new CYP3A4 inhibitor from grape fruit juice显示文摘 | Tomihisa O Takuro M Minoru N | | 0，，： | 1 |
| 11 | Inheritance mode of mierosatellite DNA markers and their use for kinship estimation in Kuruma prawn Penaeus japonicus 显示文摘 | Takuma S Minoru I Hideshi M | 2002 | Fisheries Science2002，68，： | 1 |
| 12 | The Purple leaf (Pl) locus of rice: the Plw allele has a complex organization and includes two genes encoding basic helix-loop-helix proteins involved in anthocyanin biosynthesis显示文摘 | Wataru S Taku O Keisuke K Chikara M Akira S Minoru M Kazuhiko N Masahiko M | 2001 | Plant Cell Physiol2001，42，9： | 1 |
| 13 | Impaimd joint propfionceptionin patients with cervical myelopathy显示文摘 | Hiroyuki T Himstugu M Minoru D el al | 2005 | Spine2005，30，： | 1 |
| 14 | Transverse shape analysis o xylem ground tissues by Fourier transform image analysisⅠTrial for statistical expression of cell arrangements wit fluctuation显示文摘 | Yoko M Yoji I Minoru F | 2005 | Journal of Wood Science2005，51，20： | 1 |
| 15 | Treatment for psychological dependence on morphine : Usefulness of inhibiting NMDA receptor and its associated protein kinase in the nucleus accumbens 显示文摘 | Minoru N Hideaki K Kan M | 2005 | Life Sci2005，77，： | 1 |
| 16 | Chipping in high precision slot grinding of Mn-Zn ferrite 显示文摘 | YOSHIFUMI O TETSUO M MINORU S | 1995 | CIRP Annals-Manufacturing Technology1995，44，1： | 1 |
| 17 | Transverse shape analysis of xylem ground tissues by Fourier transform image analysis II : Cell wall direction and reconstruction of cell shapes显示文摘 | Yoko M Minoru F | 2005 | Journal of Wood Science2005，51，3： | 1 |
| 18 | Electrochemical properties of ceria-based oxides for use in intermediate-temperature SOFCs显示文摘 | Toshiaki M Minoru I Atsushi M Iempachi O | 2005 | Solid State Ionics2005，176，： | 1 |
| 19 | Development of the Electronic Instrument Transformers for Intelligent Substation显示文摘 | MINORU S KAZUO K YASUHIRO M | 2003 | TMT&D Review2003，，1： | 1 |
| 20 | Kinetic study of Li-ion extraction and insertion at LiMn2O4 single particle electrodes using potential step and impedance methods显示文摘 | Kaoru D Mohamed M Minoru U | 2003 | J Electrochem Soc2003，150，： | 1 |
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