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| 1 | MicroRNA in TLR signaling and endotoxin tolerance显示文摘Toll-like receptors(TLRs)in innate immune cells are the prime cellular sensors for microbial components.TLR activation leads to the production of proinflammatory mediators and thus TLR signaling must be properly regulated by various mechanisms to maintain homeostasis.TLR4-ligand lipopolysaccharide(LPS)-induced tolerance or cross-tolerance is one such mechanism,and it plays an important role in innate immunity.Tolerance is established and sustained by the activity of the microRNA miR-146a,which is known to target key elements of the myeloid differentiation factor 88(MyD88)signaling pathway,including IL-1 receptor-associated kinase(IRAK1),IRAK2 and tumor-necrosis factor(TNF)receptor-associated factor 6(TRAF6).In this review,we comprehensively examine the TLR signaling involved in innate immunity,with special focus on LPS-induced tolerance.The function of TLR ligand-induced microRNAs,including miR-146a,miR-155 and miR-132,in regulating inflammatory mediators,and their impact on the immune system and human diseases,are discussed.Modulation of these microRNAs may affect TLR pathway activation and help to develop therapeutics against inflammatory diseases. | Md A Nahid Minoru Satoh Edward KL Chan | 2011 | Cellular & Molecular Immunology2011，8，5： | 34 |
| 2 | A hexapod walking machine with decoupled freedoms显示文摘 | Makoto K Minoru A Kazuo T | 1985 | IEEE Journal of Robotics and Automation Ra1985，1，4： | 1 |
| 3 | Alteration of serum cytokine balance amony differeit phases of chronic hepatitis B virus infection显示文摘 | Minoru A Tetsu Y Akihiko O | 2006 | Hepatology Research2006，34，： | 1 |
| 4 | Electrochemical properties of LiFePO4 thin films prepared by pulsed laser deposition显示文摘 | CHIHIRO Y YASUTOSHI I JEONG S K TAKESHI A MINORU I ZEMPACHI O | 2005 | J Power Sources2005，146，： | 1 |
| 5 | Molecular Cloning and Expression of a Toll Receptor Gene Homologue from the Silkworm,Bombyx mori显示文摘 | Minoru Yamakawa | 2002 | Biochimica et Biophysica Acta2002，1576，： | 1 |
| 6 | Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina 显示文摘 | Minoru T Yasushi A Haruhiko Y | 2002 | Stem Cells2002，20，： | 1 |
| 7 | A web-based tool for principal component and significance analysis of microarray data显示文摘 | ALEXEI A S DAWOOD B D MINORU S H K | 2005 | Bioinformatics2005，21，10： | 1 |
| 8 | Behaviour of cobalt infiltration and abnormal grain growth during sintering of diamond on cobalt substrate 显示文摘 | SHIMING H MINORU A | 1988 | Journal of Materials Science1988，，23： | 1 |
| 9 | Determination of young' s modulus and poisson ratio of lump ores 显示文摘 | Minoru A and Yasuo O | 1983 | Tetsu - to - Hagane1983，69，7： | 1 |
| 10 | Preparation of c-axis oriented thin films of LiCoO 2 by pulsed laser deposition and their electrochemical properties显示文摘 | Yasutoshi I Minoru I Takeshi A | 2001 | J Power Sources2001，94，： | 1 |
| 11 | Synthesis of fine grained polycrystalline diamond compacts显示文摘 | HONG S M MINORU A | 1991 | New Diamond Science and Technology1991，，2： | 1 |
| 12 | Dissolution behaviottr of fine particles of diamond under high pressure sintering condition 显示文摘 | HONG S M MINORU A | 1991 | Journal of Materials Science Letters1991，，10： | 1 |
| 13 | Development of a simple preparation method for tea-seed saponins and investigation on their antiyeast activity 显示文摘 | YAMAUCHI Y KEIKO A MINORU T | 2001 | JARQ2001，35，3： | 1 |
| 14 | KEGG for linking genomes to life and the environment显示文摘 | Minoru K Michihiro A Susumu G | 2008 | Nucleic Acids Res2008，36，10： | 1 |
| 15 | A dual role of intraeellutar trehalose in the resistance of yeastcells to water stress 显示文摘 | Fumihiko S Naoki A Minoru S | 1999 | Cryobiology1999，39，： | 1 |
| 16 | A method for determining the spring constant of cantilevers for atomic force microscopy显示文摘 | Minoru Sasaki Kazuhiro Hane | 1996 | Measurement Science and Technology1996，7，： | 1 |
| 17 | Bone marrowderived stem cells can differentiate into retinal cells in injured rat retina 显示文摘 | Minoru T Yasushi A Haruhiko Y | 2002 | Stem Cells2002，20，： | 1 |
| 18 | Theantioxidant effects of phospholipids on perilla oil显示文摘 | MINORU K GA-SENOUNG C YOSHIHIRO I A | 1991 | JAOCS1991，68，2： | 1 |
| 19 | Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina显示文摘 | Minoru T Yasushi A Haruhiko Y | 2002 | Stem cells2002，20，： | 1 |
| 20 | Pristane in salmon muscle lipid显示文摘 | NORIO I YUKO H MINORU A | 1973 | Suisan Gakubu Kenkyu Iho1973，23，9： | 1 |
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