1篇
您的检索式：作者名="Minoretti P."
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 血浆骨桥蛋白水平对于慢性稳定型心绞痛患者的预后意义显示文摘Aims: Levels of the secreted glycophosphoprotein osteopontin(OPN) have been associated with the presence and extent of coronary artery disease(CAD). The present study assessed the relationship between plasma OPN concentrations and prognosis in patients with chronic stable angina(CSA). Methods and results: OPN was measured in baseline plasma samples from 799 patients with stable angina pectoris and angiographically documented CAD. Participants were prospectively followed-up for a median of 2.7 years(maximum 4.1 years). The primary study endpoint was the composite of non-fatal myocardial infarction and death from cardiovascular causes. In the univariate Cox proportional hazard analysis, the log-transformed OPN level [hazard ratio(HR) 1.79, 95% CI 1.35-2.36, P< 0.001] was significantly related to adverse outcome. In addition, hypertension, levels of C-reactive protein, and statin use were associated with future adverse events. Levels of OPN(HR, 1.88; P< 0.001) and C-reactive protein(HR, 1.42; P=0.003), as well as the presence of hypertension(HR, 2.39; P=0.008) remained statistically significant, independent predictors of adverse cardiovascular outcome in a multivariable Cox proportional hazard analysis. Conclusion: Baseline levels of OPN are an independent predictor of future adverse cardiac events in patients with CSA and may be useful for risk stratification. | Minoretti P. Falcone C. Calcagnino M. D. Geroldi 王亭忠 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员