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| 1 | Vaccinations in immunosuppressive-dependent pediatric inflammatory bowel disease显示文摘AIM To determine the vaccination rates in pediatric immunosuppression-dependent inflammatory bowel disease(IBD) and review the safety and efficacy of vaccinations in this population.METHODS The electronic medical records from October 2009 to December 2015 of patients diagnosed with IBD at 10 years of age or younger and prescribed antitumor necrosis factor alpha(anti-TNF-α) therapy were reviewed for clinical history, medication history, vaccination history, and hepatitis B and varicella titers. Literature discussing vaccination response in IBD patients were identified through search of the MEDLINE database and reviewed using the key words 'inflammatory bowel disease', 'immunization', 'vaccination', 'pneumococcal', 'varicella', and 'hepatitis B'. Non-human and non-English language studies were excluded. Search results were reviewed by authors toselect articles that addressed safety and efficacy of immunizations in inflammatory bowel disease.RESULTS A total of 51 patients diagnosed with IBD prior to the age of 10 and receiving anti-TNF-α therapy were identified. Thirty-three percent of patients(17/51) had incomplete or no documentation of vaccinations. Sixteen case reports, cohort studies, cross-sectional studies, and randomized trials were determined through review of the literature to describe the safety and efficacy of hepatitis B, pneumococcal, and varicella immunizations in adult and pediatric patients with IBD. These studies showed that patients safely tolerated the vaccines without significant adverse effects. Importantly, IBD patients receiving immunosuppressive medications, particularly anti-TNF-α treatment, have decreased vaccine response compared to controls. However, the majority of patients are still able to achieve protective levels of specific antibodies. CONCLUSION Immunizations have been shown to be well-tolerated and protective immunity can be achieved in patients with IBD requiring immunosuppressive therapy. | Huyen-Tran Nguyen Phillip Minar Kimberly Jackson Patricia C Fulkerson | 2017 | World Journal of Gastroenterology2017，23，42： | 2 |
| 2 | D-dimer levels and risk of recurrent venous thromboembolism显示文摘 | Eichinger S Minar E Bialonczyk C | 2003 | JAMA2003，290，8： | 1 |
| 3 | The Risk of Recurrent Venous Thmmbolism in Men and Women 显示文摘 | Kyrle PA Minar E Bialonciyk C | 2004 | The Nen England Journal of Medicine2004，350，： | 1 |
| 4 | D-dimer levels and risk of re- current venous thromboembolism 显示文摘 | Eichinger S Minar E Bialonczyk C | 2003 | JAMA2003，290，8： | 1 |
| 5 | The Risk of Recurrent Venous Thrombolism in Men and Women 显示文摘 | Kyrle PA Minar E Bialonciyk C | 2004 | The Nen England Joumalof Medicine2004，350，： | 1 |
| 6 | D-dimer levels and risk of recurrent venous thromboembolism 显示文摘 | Eichinger S Minar E Bialonczyk C | 2003 | AMA2003，290，9： | 1 |
| 7 | The risk of recurrent venous thromboembolism in men and women 显示文摘 | Kyrle PA Minar E Biahmczyk C | 2004 | N Engl J Med2004，350，25： | 1 |
| 8 | D-dimer levels and riskof recurrent venous thromboembolism显示文摘 | Eichinger S Minar E Bialonczyk C | 2003 | JAMA2003，290，8： | 1 |
| 9 | The risk of recurrent venousthromboembolism in men and women 显示文摘 | Kyrle PA Minar E Bialonczyk C | 2004 | N Engl J Med2004，350，25： | 1 |
| 10 | The risk of recurrentvenous thromboembolism in men and women 显示文摘 | Kyrle PA Minar E Bialonczyk C | 2004 | N Engl JMed2004，350，25： | 1 |
| 11 | D-dimer levels and risk of recurrent venous thromboembolism显示文摘 | Eichinger S Minar E Bialonczyk C | 2003 | JAMA2003，290，8： | 1 |
| 12 | Evaluating the communication performance on an Ad hoc wireless network显示文摘 | TOH C K MINAR D DONALD A | 2002 | IEEE Yrans on Wireless Communications2002，1，3： | 1 |
| 13 | The risk of recurrent venous thromboembolism in men and women显示文摘 | Kyrle PA Minar E Bialonczyk C | 2004 | New Eng J Med2004，350，： | 1 |
| 14 | D-dimer levels and risk of recurrent venous thromboembolism显示文摘 | Eichinger S Minar E Bialonezyk C | 2003 | AMA2003，290，9： | 1 |
| 15 | Inflamma- tion and Carotid AJlery - Risk for Atherosclerosis study (ICARAS) 显示文摘 | Schillinger M Exner M Mlekusch W Sabeti S Amighi J Nikowitsch R Timmel E Kickinger B Minar C Pones M Lalouschek W Rumpold H Maurer G Wagner O Minar E | 2005 | Circulation2005，111，17： | 1 |
| 16 | The risk of recurrent ve-nous thromboembolism in men and women显示文摘 | Kyrle PA Minar E Bialonczyk C | 2004 | N Engl J Med2004，350，25： | 1 |
| 17 | Thermoregulation and rheological properties of blood in primary Raynaud's phenomenon and the vibration-induced white-finger syndrome显示文摘 | Ziegler S Zoch C Gschwandtner M Eckhardt G Windberger U Minar E Rudiger H Osterode W | 2005 | Int Arch Occup Environ Health2005，78，3： | 1 |
| 18 | The risk of recurrentvenous thromboembolism in men and women 显示文摘 | Kyrle PA Minar E Bialonczyk C | 2004 | N Engl JMed2004，350，25： | 1 |
| 19 | The impact of uric acid on long-term mortality in patients with asymptomatic ca- rotid atherosclerotic disease显示文摘 | Mayer FJ Mannhalter C Minar E | 2014 | J Stroke Cerebrovasc Dis2014，9，14： | 1 |
| 20 | D-dimer levels and risk of recurrent venous thromboembolism显示文摘 | Eichinger S Minar E Bialonczyk C | 2003 | JAMA2003，290，8： | 1 |
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