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| 1 | Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy显示文摘IgG 的 Fc 区域的 Glycosylation 在安全和治疗学的抗体的临床的功效上有深刻影响。当复杂类型的 oligosaccharide 纳入了 Fc 的 Asn297 的 biantennary 为抗体受动器功能是必要的时,海藻糖和外部手臂的糖属于核心 heptasaccharide 产生结构的异质(glycoforms ) 展出唯一的生物活动。因此,有效、量的 glycan 分析技术为治疗学的抗体的发展和质量控制是日益重要的,并且 Fc 的 glycan 侧面作为批评优秀属性被认出。在过去的十年,我们 IgG-Fc 的结构 / 功能上的 glycosylation 的影响的理解通过 X 光检查结晶、原子的磁性的回声研究很快成长了,它为新奇抗体治疗学的设计提供可能性。而且,用基于 endoglycosidase 的 glycosynthases 的 chemoenzymatic glycoengineering 途径可以作为下一代的治疗学的抗体与理想的功能便于同类的 IgG glycoforms 的发展。因此, Fc glycans 是在精确药的时代的治疗学的 IgG 抗体的安全,功能,和功效的改进的肥沃的地面。 | Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd | 2018 | Protein & Cell2018，9，1： | 2 |
| 2 | Preoperative change of thyroid stimulating hormone receptor antibody level:possible marker for predicting recurrent hyperthyroidism in patients with Graves,dis ease after subtotal thyroidectomy显示文摘 | Mimura T Ozaki O | 1996 | Worly J Surg1996，20，7： | 1 |
| 3 | Retinal vein occlusion followed by ischemic optic neuropathy with anticardiolipin IgG antibody:a case report显示文摘 | Yamamoto T Mimura O Kawasaki T | 2009 | Nippon Ganka Gakkai Zasshi2009，113，10： | 1 |
| 4 | Retinal vein occlusion followed by ischemic optic neuropathy with anticardiolipin IgG antibody:a case report显示文摘 | Yamamoto T Mimura O Kawasaki T | 2009 | Nippon Ganka Gakkai Zasshi2009，113，10： | 1 |
| 5 | Early prediction of preterm delivery by transvaginal ultrasonography显示文摘 | Okitsu O Mimura T Nakayama T | | 0，，06： | 1 |
| 6 | Bilateral trochlear nerve palsies from a brainstem hematoma显示文摘 | Tachibana H Mimura O Shiomi M | | 0，，： | 1 |
| 7 | Fish-tail resection for treating congenital entropion in Asians显示文摘 | Nakauchi K Mimura O | 2012 | Clin Ophthalmol2012，6，： | 1 |
| 8 | Frontal suspension for congenital ptnsis using an expanded polytetrafluoroethyene (Gore-Tex ) sheet : one-year follow-up显示文摘 | Nakauchi K Mito H Mimura O | 2013 | Clin Ophthalmol2013，7，： | 1 |
| 9 | Preoperative change of thyroid stimulating hormone receptor antibody level:possible marker for predicting recurrent hyperthyroidism in patients with Graves' disease after subtotal thyroidectomy显示文摘 | Sugino K Mimura T Ozaki O | 1996 | World J Surg1996，20，7： | 1 |
| 10 | Fish-tail resection for treating congenital entropion in Asians显示文摘 | Nakauchi K Mimura O | 2012 | Clin Ophthalmol2012，6，： | 1 |
| 11 | Preoperative change of thyroid stimulating hormone receptor antibody level:possible marker for predict i ng recu r rent hy per thy roidism i n pat ients with G r ave s'd i s e a s e a f t e r s u bt ot a l t hy r oid e c t omy显示文摘 | Sugino K Mimura T Ozaki O | 1996 | World J Surg1996，20，7： | 1 |
| 12 | Preoperative change of thyroid stimulating hormone receptor antibody level:possible marker for predicting recurrent hyperthyroidism in patients with Graves'disease after subtotal thyroidectomy显示文摘 | Sugino K Mimura T Ozaki O | 1996 | World J Surg1996，20，7： | 1 |
| 13 | Ciliochoroidal effusion syndrome associated with posterior seleritis 显示文摘 | IKEDA N IKEDA T NOMURA C MIMURA O | 2007 | Jpn J Ophthalmol2007，51，1： | 1 |
| 14 | Frontal suspension for congenital ptosis using an expanded polytetrafluoroethylene (Gore-Tex ) sheet : one-year follow-up显示文摘 | Nakauchi K Mito H Mimura O | 2013 | Clin Ophthalmol2013，7，： | 1 |
| 15 | Fish-tail resection for treating congeni- tal entropion in Asians 显示文摘 | Nakauchi K Mimura O | 2012 | Clin Ophthalmol2012，6，： | 1 |
| 16 | Ana plastic transformation of papillary thyroid carcinoma in recurrent in regional lymph nodes:a histological and immunohistochemical study显示文摘 | OZAKI O ITO K MIMURA T | 1999 | J Surge Oncology1999，70，1： | 1 |
| 17 | Fish-tail resection for treating congenital entropion in Asians显示文摘 | Nakauehi K Mimura O | 2012 | Clin Ophthalmol2012，6，： | 1 |
| 18 | Fish tail resection for treating con genital entropion in Asians 显示文摘 | Nakauchi K Mimura O | 2010 | Clin Ophthalmol2010，6，： | 1 |
| 19 | Surgery for patients with thyroid carcinoma invading the trachea: circumferential sleeve re- section followed by end-to-end anastomosis 显示文摘 | Ozaki O Sugino K Mimura T | 1995 | Surgery1995，117，3： | 1 |
| 20 | Early recurrence of hyperthy- roidism in patients with Graves' disease treated by subtotal thy- roidectomy显示文摘 | Sugino K Mimura T Ozaki O | 1995 | World J Surg1995，，4： | 1 |
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