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| 1 | Changes in nutrient intakes of elimentary school children following a school-based intervention显示文摘 | Leslie AL Elaine JS Milton ZN | 1996 | Pre Med1996，25，： | 1 |
| 2 | Cue-induced cocaine seeking and re- lapse are reduced by disruption of drug memory reconsolidation显示文摘 | Lee JL Milton AL Everitt BJ | 2006 | J Neurosci2006，26，： | 1 |
| 3 | Reconsolidation and extinction of conditioned fear: inhibition and potentiation 显示文摘 | Lee JL Milton AL Everitt BJ | 2006 | J Neurosci2006，26，10： | 1 |
| 4 | lntra-amygdala and systemic antagonism of NMDA receptors prevents the reeonsolida- tion of drug-associated memory and impairs subsequently beth novel and previously acquired drug-seeking behaviors显示文摘 | Milton AL Lee JL Butler VJ Gardner R Everitt BJ | 2008 | J Neurosci2008，28，： | 1 |
| 5 | Cue - induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation显示文摘 | Lee JL Milton AL Everitt BJ | 2006 | J Neurosci2006，26，22： | 1 |
| 6 | The basolateral amygdala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidation显示文摘 | Théberge FR Milton AL Belin D Lee JL Everitt BJ | 2010 | Learn Mem2010，17，9： | 1 |
| 7 | Reconsolidation and extinction of conditioned fear:inhibition and potentiation显示文摘 | Lee JL Milton AL Everitt BJ | 2006 | J Neurosci2006，26，10： | 1 |
| 8 | The basolateral amygdala and nucleus aceumbens core mediate dissociable aspects of drug memory reconsolidation显示文摘 | Theberge FR Milton AL Belin D | 2010 | Learn Mem2010，17，9： | 1 |
| 9 | Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent onβ-adrenergic receptors显示文摘 | Milton AL Lee JL Everitt BJ | 2008 | Learn Mem2008，15，2： | 1 |
| 10 | Intra-amygdala and systemic antagonism of NMDA receptors prevents the reconsolidation of drug-associated memory and impairs subsequently both novel and previously acquired drugseeking behaviors显示文摘 | Milton AL Lee JL Butler VJ Gardner R Everitt BJ | 2008 | J Neurosci2008，28，33： | 1 |
| 11 | The psychological and neurochemical mechanisms of drug memory reconsolidation:implications for thetreatment of addiction显示文摘 | Milton AL Everitt BJ | 2010 | Eur J Neurosci2010，31，12： | 1 |
| 12 | The psychological and neurochemical mechanisms of drug memory reconsolidation:implications for the treatment of addiction显示文摘 | Milton AL Everitt BJ | 2010 | Eur J Neurosci2010，31，： | 1 |
| 13 | Functional biomarker signatures of circulating T-cells and its association with distinct clinical status of leprosy patients and their respective household contacts显示文摘Background: Leprosy is a chronic infectious disease classified into two subgroups for therapeutic purposes:paucibacillary(PB)and multibacillary(MB),closely related to the host immune responses.In this context it is noteworthy looking for immunological biomarkers applicable as complementary diagnostic tools as well as a laboratorial strategy to follow-up leprosy household contacts.Methods:: The cross-sectional study enrolled 49 participants,including 19 patients and 30 healthy controls.Peripheral blood mononuclear cells(PBMC)were isolated and incubated in the presence of Mycobacterium leprae bacilli.The cells were prepared for surface(CD4+and CD8+)and intracytoplasmic cytokine staining(IFN-γ,IL-4 and IL-10).Multiple comparisons amongst groups were carried out by ANOVA,Kruskal–Wallis,Student T or Mann–Whitney test.Comparative analysis of categorical variables was performed by Chi-square.Functional biomarker signature analysis was conducted using the global median values for each biomarker index as the cut-off edge to identify the proportion of subjects with high biomarker levels.Results: The cytokine signature analysis demonstrated that leprosy patients presented a polyfunctional profile of T-cells subsets,with increased frequency of IFN-γ+T-cell subsets along with IL-10+and IL-4+from CD4+T-cells,as compared to health Controls(Venn diagram report).Moreover,statistical analysis was carried out using parametric or non-parametric variance analysis followed by pairwise multiple comparisons,according to the data normality distribution.L(PB)displayed a polyfunctional profile characterized by enhanced percentage of IFN-γ+,IL-10+and IL-4+produced by most T-cell subsets,as compared to L(MB)that presented a more restricted cytokine functional profile mediated by IL-10+and IL-4+T-cells with minor contribution of IFN-γproduced by CD4+T-cells.Noteworthy was that HHC(MB)exhibited enhanced frequency of IFN-γ+T-cells,contrasting with HHC(PB)that presented a cytokine profile limited to IL-10 and IL-4.Conclusions: Our data demonstrated that L(PB)displayed enhanced percentage of IFN-γ+,IL-10+and IL-4+as compared to L(MB)that presented functional profile mediated by IL-10+and IL-4+T-cells and HHC(MB)exhibited enhanced frequency of IFN-γ+T-cells,contrasting with HHC(PB).Together,our findings provide additional immunological features associated with leprosy and household contacts.These data provide evidence that biomarkers of immune response can be useful complementary diagnostic/prognostic tools as well as insights that household contacts should be monitored to access putative subclinical infection. | Pedro Henrique Ferreira Marçal Rafael Silva Gama Lorena Bruna Pereira de Oliveira Olindo Assis Martins-Filho Roberta Olmo Pinheiro Euzenir Nunes Sarno Milton Ozório Moraes Lucia Alves de Oliveira Fraga | 2020 | Infectious Diseases of Poverty2020，9，6： | 1 |
| 14 | Effect of the carriers on the microstructure of mango powder obtained by spray drying and its functional charaeterization显示文摘 | Milton Cano-Chauca P C Stringheta A M Ramos 6t al | 2005 | Innovative Food Science and Emerging Technologies2005，，42： | 1 |
| 15 | Bidirectional modulation of alcohol-associated memory reconsolidation through manipulation of adrenergic signaling显示文摘 | Schramm MJ Everitt BJ Milton AL | 2016 | Neuropsychopharmacology2016，41，4： | 1 |
| 16 | Theories of general personality and mental disorder显示文摘 | Duggan C Milton J Egan V st al | 2003 | Br J Psychiatry Suppl2003，44，： | 1 |
| 17 | The psychological and neurochemical mechanisms of drug memory reconsolidation : implications for the treatment of addiction 显示文摘 | Milton AL Everitt BJ | 2010 | Eur J Neurosci2010，31，12： | 1 |
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