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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 3 | Rictor and inte-grinlinked kinase interact and regulate Akt phosphoryla-tion and cancer cell survival显示文摘 | McDonald PC Oloumi A Mills J | 2008 | Cancer Res2008，68，16： | 1 |
| 4 | Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival显示文摘 | McDonald PC Oloumi A Mills J et at | 2008 | Cancer Res2008，68，6： | 1 |
| 5 | Use of C-reactive protein in minimizing antibiotic exposure:experience with infants initially admitted to a wellbaby nursery显示文摘 | MILLS PC | 2000 | Pediatrics2000，106，： | 1 |
| 6 | Rictor and integrinlinked kinase interact and regulate Akt phosphorylation and cancer cell survival 显示文摘 | McDonald PC Oloumi A Mills J | 2008 | Cancer Res2008，68，6： | 1 |
| 7 | Rictor and integrin -linked kinase interact and regulate Akt phosphorylation and cancer cell survival 显示文摘 | McDonald PC Oloumi A Mills J | 2008 | Cancer Res2008，68，6： | 1 |
| 8 | Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival显示文摘 | McDonald PC Olonmi A Mills J | 2008 | Cancer Res2008，68，6： | 1 |
| 9 | 2D line-scan photoacoustic imaging of absorbers in a scattering tissue phantom显示文摘 | Beard PC Mills TN | 2001 | Proc SPIE2001，4256，： | 1 |
| 10 | Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival显示文摘 | McDonald PC Oloumi A Mills J | 2008 | Cancer Res2008，68，6： | 1 |
| 11 | Performance of breathing filters under wet conditions a laboratory evaluation显示文摘 | Fisher PC Mills GH | 2005 | Br J Anaesth2005，94，： | 1 |
| 12 | Performance of breathing filters Under wet eonditions: a laboratory evaluation 显示文摘 | Turnbull D Fisher PC Mills GH | 2005 | Br J Anaesth2005，94，5： | 1 |
| 13 | Indications,durations and outcomes of?mechanicalventilation?in dogs and cats with tick paralysis caused by Ixodes holocyclus:61 cases(2008-2011)显示文摘 | Webster RA Mills PC Morton JM | 2013 | Aust Vet J2013，91，6： | 1 |
| 14 | Rictor and integrin-linked kinase interact and regulate Akt phosphorylation andcancer cell survival显示文摘 | McDonald PC Oloumi A Mills J | 2008 | Cancer Res2008，68，6： | 1 |
| 15 | Use of C-reactive protein in minimizing antibiotic exposure:experience with infants initially admitted to a well-baby nursery显示文摘 | Philip AG Mills PC | 2000 | Pediatrics2000，106，1： | 1 |
| 16 | Cumulative risk assessment in unstable angina:clinical,electrocardiographic,autonomic,and biochemical markers显示文摘 | Kennon S Price CP Mills PC | 2003 | Heart2003，89，： | 1 |
| 17 | Profile of patients with spinal cord injuries and occurrence of pressure ulcer at a university hospital 显示文摘 | Nogueira PC Caliri MILL Haas YJ | 2006 | Lat Am Enfermagem2006，14，3： | 1 |
| 18 | Relationship between coronary artery remodeling and plaque vulnerability显示文摘 | Varnava AM Mills PC Davies MJ | 2002 | Circulation2002，105，8： | 1 |
| 19 | Effects of exercise intensity and environmental stress on indices of oxidative stress and iron homeostasis during exercise in the horse显示文摘 | Smith NC | 1996 | Eur J Appl Physiol Occup Physiol1996，74，12： | 1 |
| 20 | Teaching histology to firs-t yearveterinary science students using virtual microscopy and traditional m-icroscopy:a comparison of student responses显示文摘 | Mills PC Bradley AP Woodall PF | 2007 | J Vet Med Educ2007，34，2： | 1 |
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