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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | Protein localization in living cells and tissues using FRET and FLIM显示文摘 | Chen Y Mills JD Periasamy A | 2003 | Differentiation2003，，910： | 2 |
| 3 | Urinary diversion 显示文摘 | World Health Organization (WHO) Conference in Bladder Cancer Hautmann RE Abol-Enein H Hafez K Haro I Mansson W Mills RD Montie JD Sagalowsky AI Stein JP Stenzl A Studer UE Volkmer BG | 2007 | Urology2007，，： | 1 |
| 4 | Differential regulation of macrophage arginine metabolism:a proposed role in wound healing显示文摘 | Shearer JD Richards JR Mills CD | 1997 | Am J Physiol1997，272，21： | 1 |
| 5 | Coronary collateral development during chronic ischemia: serial assessment using harmonic myocardial contrast echocardiography显示文摘 | Mills JD Fischer D Villanueva FS | 2000 | J Am Coll Cardiol2000，36，2： | 1 |
| 6 | Cardio-selective and non-selective beta blockers in chronic obstructive pul monary disease: effects on bronchodilator response and exer- cise显示文摘 | Chang CL Mills GD MeLaehlan JD | 2010 | Int Med J2010，40，3： | 1 |
| 7 | Dysregulation of antioxi- dant mechanisms contributes to increased oxidative stress in cal- cific aortic valvular stenosis in humans显示文摘 | Mille JD Chu Y Brooks RM | 2008 | J Am Coll Cardiol2008，52，10： | 1 |
| 8 | The importance of early diagnosis and surgical treatment ofnecrotizing fascitis, 显示文摘 | Mill JD | 1983 | Surg Gynecol Obstet1983，157，3： | 1 |
| 9 | Factor XIII-circulating levels and the Val34Leu polymorphism in the healthy male relatives of patients with severe coronary artery disease显示文摘 | Mansfield MW Grant PJ | 2002 | Thromb Haemost2002，87，3： | 1 |
| 10 | Omega-3 fatty acid supplementation and reduction of traumatic axonal injury in a rodent head injury model显示文摘 | Mills JD Bailes JE Sedney CL | 2011 | J Neurosurg2011，114，1： | 1 |
| 11 | A new look at out- comes after infrainguinal bypass surgery: traditional reporting standards systematically underestimate the expenditure of effort required to attain limb salvage 显示文摘 | Goshima KR Mills JL Sr Hughes JD | 2004 | J Vasc Surg2004，39，2： | 1 |
| 12 | Understanding strategies for the treatment of ischemic steal syndrome after hemodialysis access显示文摘 | Wixon CL Hughes JD Mills JL | | 0，，： | 1 |
| 13 | Characterization of age and dose related out comes of duck hepatitis B virus infection显示文摘 | BOTTEN JD MILL ER DS | 1998 | Virology1998，，244： | 1 |
| 14 | Improved patency of infrainguinal polytetrafluoroethylene bypass grafts using a distal Taylor vein patch显示文摘 | Yeung KK Mills JL Hughes JD | 2001 | Am J Surg2001，182，6： | 1 |
| 15 | Omega-3 fatty acid supplementation and reduction of traumatic axonal injury in a rodent head injury model 显示文摘 | Mills JD Bailes JE Sedney CL | 2011 | J Neurosurg2011，114，1： | 1 |
| 16 | Indexing Disease Progres- sion at Study Entry with inDividuals At-risk for Huntington Dis- ease显示文摘 | Zhang Y Long JD Mills JA | 2011 | Am J Med Genet B Neuropsychiatr Genet2011，156，7： | 1 |
| 17 | Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD显示文摘 | Mc Allister DA Maclay JD Mills NL | 2012 | Eur Respir J2012，39，5： | 1 |
| 18 | Coronary collateral development during chronic ischemia: serial assessment using harmonic myocardial contrast echocardiography显示文摘 | Mills JD Fischer D Villanueva FS | 2000 | J Am Coll Cardiol2000，6，2： | 1 |
| 19 | Cardioselective and non-selective beta-blockers in chronic obstructive pulmonary disease: effects on bronchodilator response and exercise 显示文摘 | Chang CL Mills GD McLachlan JD | 2010 | Intern Med J2010，40，3： | 1 |
| 20 | Vascular dysfunction in chronic obstructive pulmonary disease 显示文摘 | Maclay JD McAllister DA Mills NL | 2009 | Am J Respir Crit Care Med2009，180，6： | 1 |
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