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| 1 | Concordance among indices of intrinsic brain function: Insights from inter-individual variation and temporal dynamics显示文摘Various resting-state fMRI(R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the common and unique aspects these indices capture. The present work provided a comprehensive examination of inter-individual variation and intra-individual temporal variation for commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity,voxel-mirrored homotopic connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation, which doesn't exist in phase randomized surrogate data. As a measure of intrinsic brain function, concordance for R-fMRI indices was negatively correlated with age across individuals(i.e., concordance among functional indices decreased with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual(i.e., high vs. low concordance participants) or intra-individual(i.e., high vs.low concordance states identified via temporal dynamic analyses) differences. We also noted a linear increase in functional concordance together with the R-fMRI indices through the scan, which may suggest a decrease in arousal. The current study demonstrated an enriched picture regarding the relationship among the R-fMRI indices, as well as provided new insights in examining dynamic states within and between individuals. | Chao-Gan Yan Zhen Yang Stanley J. Colcombe Xi-Nian Zuo Michael P. Milham | 2017 | Science Bulletin2017，62，23： | 13 |
| 2 | Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: A pilot study显示文摘People with schizophrenia exhibit impaired social cognitive functions, particularly emotion regulation. Abnormal activations of the ventral medial prefrontal cortex (vMPFC) during emotional tasks have been demonstrated in schizophrenia, suggesting its important role in emotion processing in patients. We used the resting-state functional connectivity approach, setting a functionally relevant region, the vMPFC, as a seed region to examine the intrinsic functional interactions and communication between the vMPFC and other brain regions in schizophrenic patients. We found hypo-connectivity between the vMPFC and the medial frontal cortex, right middle temporal lobe (MTL), right hippocampus, parahippocampal cortex (PHC) and amygdala. Further, there was a decreased strength of the negative connectivity (or anticorrelation) between the vMPFC and the bilateral dorsal lateral prefrontal cortex (DLPFC) and pre-supplementary motor areas. Among these connectivity alterations, reduced vMPFC-DLPFC connectivity was positively correlated with positive symptoms on the Positive and Negative Syndrome Scale, while vMPFC-right MTL/PHC/amygdala functional connectivity was positively correlated with the performance of emotional regulation in patients. These findings imply that communication and coordination throughout the brain networks are disrupted in schizophrenia. The emotional correlates of vMPFC connectivity suggest a role of the hypo-connectivity between these regions in the neuropathology of abnormal social cognition in chronic schizophrenia. | Feng-Mei Fan Shu-Ping Tan Fu-De Yang Yun-Long Tan Yan-Li Zhao Nan Chen Bin-Bin Li Chong-Sheng Song Yun-Hui Wang Zhen Jin Dong-Feng Zhou Michael P. Milham Yi-Zhuang Zou Xi-Nian Zuo | 2013 | Neuroscience Bulletin2013，29，1： | 9 |
| 3 | Nitrogen and phosphorus requirements of cotton and wheat under changing CO2 concentrations显示文摘 | Rogers G S Payne L Milham P | 1993 | Plant and Soil1993，155，： | 1 |
| 4 | Attentional control in the aging brain:insights from a fMRI study of the stroop task显示文摘 | Milham MP Efickson KI Banich MT | 2002 | Brain Cogn2002，49，3： | 1 |
| 5 | Attentional selec - tion and the processing of task - irrelevant information, insights from fMRI examinations of the Stroop task显示文摘 | Banich MT Milham MP Jacobson BL | 2001 | Prog Brain Res2001，134，： | 1 |
| 6 | Prefrontal regions play a predominant role in imposing an attentional 'set': evidence from fMRI显示文摘 | Banich M T Milham M P Atchley R A | 2000 | Cognitive Brain Research2000，10，1： | 1 |
| 7 | Ventral striatal hypore- sponsiveness during reward anticipation in attention-deficit/hyper- activity disorder 显示文摘 | Scheres A Milham MP Knutson B | 2007 | Biol Psychiatry2007，61，5： | 1 |
| 8 | Characterizing cognition in ADHD:Beyond executive dysfunction显示文摘 | CASTELLANOS FX SONUGA-BARKE EJ MILHAM MP | 2006 | Trends Cogni Sci2006，10，3： | 1 |
| 9 | Functional homotopic changes in multiple sclerosis with resting-state functional MR imaging显示文摘 | Zhou Y Milham M Zuo XN | 2013 | AJNR Am J Neuroradiol2013，34，： | 1 |
| 10 | Attentional selection and the processing of task-irrelevant information, insights from fMRI examinations of the Strnop task 显示文摘 | Banich MT Milham MP Jacobson BL | 2001 | Prog Brain Res2001，134，3： | 1 |
| 11 | Heavy metals in the environment-survey of cadmium levels in vegetables and soils of Greater Sydney,Australia 显示文摘 | JINAD ASA K B P N MILHAM P J HAWKINS C A | 1997 | J Environ Qual1997，26，： | 1 |
| 12 | Attentional control in the aging brain:insights from an fMRJ study of the stroop task 显示文摘 | MILHAM MP | 2002 | Brain Cogn2002，49，3： | 1 |
| 13 | Characteriz- ing cognition in ADHD: Beyond executive dysfunction显示文摘 | Castellanos FX Sonuga-Barke E J Milham MP | 2006 | Trends Cogn Sci2006，10，3： | 1 |
| 14 | Attentional control in the aging brain:insights from an MRI studay of the stroop task显示文摘 | Milham MP Erickson KI Bnach MT | 2002 | Brain Cogn2002，49，： | 1 |
| 15 | Infrared optical properties of phosphorus-derived smoke 显示文摘 | MILHAM M E ANDERSON D H FRICKEL R H | 1982 | Appl Opt1982，21，14： | 1 |
| 16 | Historical evidence that residential electrifi- cation caused the emergence of the childhood leukemia peak 显示文摘 | Milham S Ossiander EM | 2001 | Med Hypotheses2001，56，： | 1 |
| 17 | Attentional con -trol in the aging brain: insights from an fMRI study of the stroop task 显示文摘 | Milham M Erickson K Banich M | 2002 | BrainCogn2002，49，3： | 1 |
| 18 | Survey of cadmium levels in vegetables and soils of greater Sydney,Australia显示文摘 | Jinadasa K B P N Milham P J Hawkkins C A | 1997 | Journal of Environmental Quality1997，26，： | 1 |
| 19 | Sink strength may be the key to growth and nitrogen responses in N-deficient wheat at elevated CO2显示文摘 | Rogers G S Milham P J Gillings M | 1996 | Aust J Plant Physiol1996，23，： | 1 |
| 20 | Characterizing Cognition in ADHD: Beyond Executive Dysfunction 显示文摘 | Castellanos F X Sonuga - Barke E J S Milham M P | 2006 | Trends in Cognitive Sciences2006，10，3： | 1 |
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