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| 1 | Numerical modeling of failure mechanisms in phyllite mine slopes in Brazil显示文摘This paper presents three case studies comprising failure mechanisms in phyllite mine slopes at Quadrilá-tero Ferrífero, State of Minas Gerais, Brazil. Numerical modeling techniques were used in this study. Failure mechanisms involving discontinuities sub parallel to the main foliation are very common in these mines. Besides, failure through the rock material has also been observed due to the low strength of phyllites in this site. Results of this work permitted to establish unknown geotechnical parameters which have significant influence in failure processes, like the in situ stress field and the discontinuity stiffness. | Lana Milene Sabino | 2014 | International Journal of Mining Science and Technology2014，24，6： | 5 |
| 2 | Hepatic encephalopathy:Lessons from preclinical studies显示文摘Hepatic encephalopathy(HE) is a major complication that is closely related to the progression of end-stage liver disease.Metabolic changes in advanced liver failure can promote cognition impairment,attention deficits and motor dysfunction that may result in coma and death.HE can be subdivided according to the type of hepatic injury,namely,type A,which results from acute liver failure,type B,which is associated with a portosystemic shunting without intrinsic liver disease,and type C,which is due to chronic liver disease.Several studies have investigated the pathogenesis of the disease,and most of the mechanisms have been explored using animal models.This article aimed to review the use of preclinical models to investigate HE.The most used animal species are rats and mice.Experimental models of type A HE include surgical procedures and the administration of hepatotoxic medications,whereas models of types B and C HE are generally surgically induced lesions in liver tissue,which evolve to hepatic cirrhosis.Preclinical models have allowed the comprehension of the pathways related to HE. | Luiza Cioglia Dias Lima Aline Silva Miranda Rodrigo Novaes Ferreira Milene Alvarenga Rachid Ana Cristina Sim?es e Silva | 2019 | World Journal of Hepatology2019，11，2： | 4 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Repaid tumor penetration of a single-chain Fv and comparison with other immunoglobulin from显示文摘 | Yokota T Milenic DE Withlow M | 1992 | Cancer Res1992，52，14： | 2 |
| 5 | In vivo evaluation of bismuth-labeled monoelonal antibody comparing DTPA-derived bifunctional chelates显示文摘 | MILENIC D E ROSELLI M MIRZADEH S | 2001 | Radiopharrn2001，16，： | 1 |
| 6 | Antibody-Targeted Radiation Cancer Therapy 显示文摘 | MILENIC DE BRADY ED BRECHBIEL MW | 2004 | Nature Rev Drug Discovery2004，3，： | 1 |
| 7 | IL-2/anti-IL-2 antibody complex enhances vaccine-mediated antigen-specific CD8+ T cell responses and increases the ratio of effector/ memory CD8+ T cell to regulatory T cell显示文摘 | Mostlxk S Lutsiak ME Milenic DE et d | 2008 | J lmmunol2008，180，7： | 1 |
| 8 | Activation of leukocyte rolling by the cysteine-rich domain and the hyper-variable region of HF3,a snake venom hemorrhagic metalloproteinnse显示文摘 | Milene C Menezes Adriana F | 2008 | FEBS Lett2008，10，： | 1 |
| 9 | An improved selection strategy and the use of acetosyringone in shoot induction medium increase almond transformation efficiency by 100-fold显示文摘 | MILENE S C CE L M OLIVEIR A M M | 2006 | Plant Cell Tissue and Organ Culture2006，85，： | 1 |
| 10 | Radiative equilibrium in the outer layers of a star: the temperature distribution and the law of darkening显示文摘 | Milen E A | 1921 | Monthly Not Roy Astron Soc1921，81，： | 1 |
| 11 | Structural correlates of an antieareinoma antibody: identification of specificity-determining residues (SDRs) and development of a minimally immunogenic antibody variant by retention of SDRs only显示文摘 | Tamura M Milenic DE Iwahashi M | 2000 | J Immunol2000，164，3： | 1 |
| 12 | Genetic diversity in soybean germplasm identified by SSR and EST-SSR markers显示文摘 | Bruno M M Milene M Maria I Z | 2010 | Pesq Agropec Bras2010，45，3： | 1 |
| 13 | Urban heritage tourism 显示文摘 | Chang T C Milens Fallond | 1996 | Annals of Tourism Research1996，，2： | 1 |
| 14 | Reproductive and possible hormonal effects of carbendazim显示文摘 | ELKIANE M R SIMONE B MILENE L ~ | 2014 | Regulatory Toxicology and Pharmacology2014，69，： | 1 |
| 15 | Construction, binding properties,metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclnal antibody cc49 显示文摘 | Milenic DE Yokota T Fipula DR | 1991 | Cancer Res1991，51，23： | 1 |
| 16 | Optical Coherence Tomography to Identify Intramucosal Carcinoma and High-Grade Dysplasia in Barrett’s Esophagus显示文摘 | John A. Evans John M. Poneros Brett E. Bouma Jason Bressner Elkan F. Halpern Milen Shishkov Gregory Y. Lauwers Mari Mino–Kenudson Norman S. Nishioka Guillermo J. Tearney | 2006 | Clinical Gastroenterology and Hepatology2006，，1： | 1 |
| 17 | Study of Heavy Metal Pollution in Sediments from the Iron Gate ( Danube River ),Serbia and Montenegro 显示文摘 | MILEN KOVIC N DAMJANOVIC M | 2005 | Polish Journal of Environmental Studies2005，14，6： | 1 |
| 18 | CDR substitutions of a humanized monoclonal antibody (CC49):contributions of individual CDRs to antigen binding and immunogenicity显示文摘 | Iwahashi M Milenic DE Padlan EA | 1999 | Mol Immunol1999，36，： | 1 |
| 19 | Criteria for Use of Groundwater as Renewable Energy Source in Geother- mal Heat Pump Systems for Building Heating/Cooling Purposes 显示文摘 | Milenic D Petar V J Vranjes A | 2010 | Energy and Buildings2010，42，3： | 1 |
| 20 | Monoclonal Antibody-Based Therapy Strategies: Providing Options for the Cancer Patien显示文摘 | Milenic DM | 2002 | Current Pharmaceutical design2002，8，： | 1 |
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