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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Pre-and intraoperative predictors of acute kidney injury after liver transplantation显示文摘BACKGROUND Acute kidney injury(AKI)after liver transplantation(LT)is a frequent and multifactorial event related to increased morbidity and mortality.Risk factors for AKI after LT still need to be clarified.AIM To identify the predictors of acute kidney injury after liver transplantation.METHODS The frequency and pre-and intraoperative predictors of AKI within the first 7 d after LT were evaluated in adult liver transplant candidates in a single LT center in Croatia.AKI was defined according to the Kidney Disease:Improving Global Outcomes criteria.RESULTS Out of 205 patients(mean age 57±10 years;73.7%males,52.7%with alcoholrelated liver disease)93(45.36%)developed AKI,and the majority of them(58.06%)had stage 1.Only 5.38%of patients required renal replacement therapy after LT.The majority of patients(82.8%)developed AKI within the first two days after the procedure.Multivariate logistic regression identified pre-LT body mass index(OR=1.1,95%CI:1.05-1.24)and red blood cell transfusion(OR=1.66,95%CI:1.09-2.53)as independent predictors of early post-LT AKI occurrence.30-d survival after LT was significantly better for patients without AKI(P=0.01).CONCLUSION Early AKI after LT is a frequent event that negatively impacts short-term survival.The pathogenesis of AKI is multifactorial,but pre-LT BMI and intraoperative volume shifts are major contributors. | Anna Mrzljak Lucija Franusic Jadranka Pavicic-Saric Tomislav Kelava Zeljka Jurekovic Branislav Kocman Danko Mikulic Ivan Budimir-Bekan Mladen Knotek | 2020 | World Journal of Clinical Cases2020，8，18： | 4 |
| 3 | Secretory IgA in complex with Lactobacillus rhamnosus potentiates mucosal dendritic cell-mediated Treg cell differentiation via TLR regulatory proteins, RALDH2 and secretion of IL-IO and TGF-β显示文摘 | Josip Mikulic Stephanie Longet Laurent Favre Jalil Benyacoub Blaise Corthesy | 2017 | Cellular & Molecular Immunology2017，14，6： | 4 |
| 4 | Liver transplantation and aging显示文摘An increase in the average life expectancy,paralleled by a demographic shift in the population with end-stage liver disease lies behind the rising demand for liver transplantation(LT)among the elderly.Some of the most common indications for LT including hepatocellular carcinoma,alcohol-related liver disease,chronic hepatitis C and non-alcoholic fatty liver disease tend to affect older patients.Transplant professionals are faced with an increasing demand for LT among elderly patients in an age of organ shortage and it is important that risk and benefits are carefully weighed in order to achieve the optimum use of precious liver grafts. | Danko Mikulic Anna Mrzljak | 2020 | World Journal of Transplantation2020，10，9： | 4 |
| 5 | Effects of plyometric vs.resistance training on skeletal muscle hypertrophy:A review显示文摘Objective:In this review,we critically evaluate studies directly comparing the effects of plyometric vs.resistance training on skeletal muscle hypertrophy.Methods:We conducted electronic searches of PubMed/MEDLINE,Scopus,SPORTDiscus,and Web of Science to find studies that explored the effects of plyometric vs.resistance training on muscle hypertrophy.Results:Eight relevant studies were included in the review.Six studies compared the effects of plyometric vs.resistance training on muscle hypertrophy,while 2 studies explored the effects of combining plyometric and resistance training vs.isolated resistance training on acute anabolic signaling or muscle hypertrophy.Based on the results of these studies,we conclude that plyometric and resistance training may produce similar effects on whole muscle hypertrophy for the muscle groups of the lower extremities.Therefore,it seems that plyometric training has a greater potential for inducing increases in muscle size than previously thought.Despite the findings observed at the whole muscle level,the evidence for the effects of plyometric training on hypertrophy on the muscle fiber level is currently limited for drawing inferences.Compared to isolated resistance training,combining plyometric and resistance exercise does not seem to produce additive effects on anabolic signaling or muscle growth;however,this area requires future study.The limitations of the current body of evidence are that the findings are specific to(a)musculature of the lower extremities,(b)short-term training interventions that lasted up to 12 weeks,and(c)previously untrained or recreationally active participants.Conclusion:This review highlights that plyometric and resistance training interventions may produce similar effects on whole muscle hypertrophy,at least for the muscle groups of the lower extremities,in untrained and recreationally trained individuals,and over short-term(i.e.,≤12 weeks)intervention periods. | Jozo Grgic Brad J.Schoenfeld Pavle Mikulic | 2021 | Journal of Sport and Health Science2021，10，5： | 3 |
| 6 | Liver transplantation for benign liver tumors显示文摘Benign liver tumors are common lesions that are usually asymptomatic and are often found incidentally due to recent advances in imaging techniques and their widespread use.Although most of these tumors can be managed conservatively or treated by surgical resection,liver transplantation(LT)is the only treatment option in selected patients.LT is usually indicated in patients that present with life-threatening complications,when the lesions are diffuse in the hepatic parenchyma or when malignant transformation cannot be ruled out.However,due to the significant postoperative morbidity of the procedure,scarcity of available donor liver grafts,and the benign course of the disease,the indications for LT are still not standardized.Hepatic adenoma and adenomatosis,hepatic hemangioma,and hepatic epithelioid hemangioendothelioma are among the most common benign liver tumors treated by LT.This article reviews the role of LT in patients with benign liver tumors.The indications for LT and long-term outcomes of LT are presented. | Ana Ostojic Anna Mrzljak Danko Mikulic | 2021 | World Journal of Hepatology2021，13，9： | 2 |
| 7 | Emerging and neglected zoonoses in transplant population显示文摘Zoonoses represent a problem of rising importance in the transplant population.A close relationship and changes between human,animal and environmental health(“One Health”concept)significantly influence the transmission and distribution of zoonotic diseases.The aim of this manuscript is to perform a narrative review of the published literature on emerging and neglected zoonoses in the transplant population.Many reports on donor-derived or naturally acquired(re-)emerging arboviral infections such as dengue,chikungunya,West Nile,tick-borne encephalitis and Zika virus infection have demonstrated atypical or more complicated clinical course in immunocompromised hosts.Hepatitis E virus has emerged as a serious problem after solid organ transplantation(SOT),leading to diverse extrahepatic manifestations and chronic hepatitis with unfavorable outcomes.Some neglected pathogens such as lymphocytic choriomeningitis virus can cause severe infection with multi-organ failure and high mortality.In addition,ehrlichiosis may be more severe with higher casefatality rates in SOT recipients.Some unusual or severe presentations of borreliosis,anaplasmosis and rickettsioses were also reported among transplant patients.Moreover,toxoplasmosis as infectious complication is a well-recognized zoonosis in this population.Although rabies transmission through SOT transplantation has rarely been reported,it has become a notable problem in some countries.Since the spreading trends of zoonoses are likely to continue,the awareness,recognition and treatment of zoonotic infections among transplant professionals should be imperative. | Anna Mrzljak Rafaela Novak Nenad Pandak Irena Tabain Lucija Franusic Ljubo Barbic Maja Bogdanic Vladimir Savic Danko Mikulic Jadranka Pavicic-Saric Vladimir Stevanovic Tatjana Vilibic-Cavlek | 2020 | World Journal of Transplantation2020，10，3： | 2 |
| 8 | Assessment of the authenticity of fruit spirits by gas chromatography and stable isotope ratio analyses显示文摘 | WINTEROV(A) R MIKUL(I)KOV(A) R MAZ(A)C J | 2008 | CzechJ Food Sci2008，26，5： | 1 |
| 9 | RF perfor-mance of lnA1N/GaN HFETs and MOSHFETs with fT * Lc up to 21 GHz * tm显示文摘 | v Kordos P Mikulics M Fox A | 2010 | IEEE Electron DeviceLett2010，31，3： | 1 |
| 10 | IL-6 and its receptors in coronary artery disease and acute myocardial infarction 显示文摘 | Anderson DR Poterueha JT Mikuls T | 2013 | Cytokine2013，62，3： | 1 |
| 11 | Rheumatoid arthritis and cardiovascular disease:the role of systemic inflammation and evolving strategies of prevention显示文摘 | Snow MH Mikuls TR | 2005 | Curt Opin Rheumatol2005，17，3： | 1 |
| 12 | Gout epidemiolo:resulta from the UK General Practice Research Database显示文摘 | Mikuls TR Farrar JT Bilker WB | 2005 | Ann rheum Dis2005，64，2： | 1 |
| 13 | Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study显示文摘 | Merlino LA Curtis J Mikuls TR | 2004 | Arthritis Rheum2004，50，： | 1 |
| 14 | Endothelin-1,big endothelin-1,and nitric oxide in patients with chronic renal disease and hypertension显示文摘 | Mikulic I Petrik J Galesic K | 2009 | J Clin Lab Ahal2009，23，6： | 1 |
| 15 | New insights into gout epidemiology显示文摘 | Mikuls TR Saag KG | 2006 | Curr Opine Rheumatol2006，181，2： | 1 |
| 16 | Vitamin D in- take is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study显示文摘 | MERLINO L A CURTIS J MIKULS T R | 2004 | Arthritis Rheum2004，50，1： | 1 |
| 17 | Gout epidemiology: results from the UK General Practice Research Database, 1990--1999显示文摘 | Mikuls TR Farrar JT Bilker WB | 2005 | Ann Rheum Dis2005，64，2： | 1 |
| 18 | Endothelin-1,big endothelin-1,and nitric oxide in patients with chronic renal disease and hypertension显示文摘 | Mikulic I Petrik J Galesic K | 2009 | J Clin Lab Anal2009，23，6： | 1 |
| 19 | Suboptimal physician adherence to quality indicators for the management of gout and asymptomatic hyperuricaemia: results from the UK General Practice Research Database (GPRD) 显示文摘 | Mikuls TR Farrar JT Bilker WB | 2005 | Rheumatology (Oxford)2005，44，8： | 1 |
| 20 | Uhrafast phenomena in fleestanding LT-GaAs devices显示文摘 | Marsch M Mikulics M Adam R | 2005 | Acta Physica Polonica A2005，107，1： | 1 |
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