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| 1 | Surface bioactivation of PEEK by neutral atom beam technology显示文摘Polyetheretherketone(PEEK)is an alternative to metallic implants and a material of choice in many applications,including orthopedic,spinal,trauma,and dental.While titanium(Ti)and Ti-alloys are widely used in many intraosseous implants due to its biocompatibility and ability to osseointegrate,negatives include stiffness which contributes to shear stress,radio-opacity,and Ti-sensitivity.Many surgeons prefer to use PEEK due to its biocompatibility,similar elasticity to bone,and radiolucency,however,due to its inert properties,it fails to fully integrate with bone.Accelerated Neutral Atom Beam(ANAB)technology has been successfully employed to demonstrate enhanced bioactivity of PEEK both in vitro and in vivo.In this study,we further characterize surfaces of PEEK modified by ANAB as well as elucidate attachment and genetic effects of dental pulp stem cells(DPSC)exposed to these surfaces.ANAB modification resulted in decreased contact angle at 72.9±4.5°as compared to 92.4±8.5°for control(p<0.01)and a decreased average surface roughness,however with a nano-textured surface profile.ANAB treatment also increased the ability of DPSC attachment and proliferation with considerable genetic differences showing earlier progression towards osteogenic differentiation.This surface modification is achieved without adding a coating or changing the chemical composition of the PEEK material.Taken together,we show that ANAB processing of PEEK surface enhances the bioactivity of implantable medical devices without an additive or a coating. | Joseph Khoury Irina Selezneva Sergei Pestov Vadim Tarassov Artem Ermakov Andrey Mikheev Mikhail Lazov Sean R.Kirkpatrick Dmitry Shashkov Alexandre Smolkov | 2019 | Bioactive Materials2019，4，1： | 2 |
| 2 | Numerical simulation of the active medium and investigation of the pump source for a photochemical XeF (C-A) amplifier of femtosecond optical pulses显示文摘 | Malinovskii G Ya Mamaev S B Mikheev L D | 2001 | Quantum Electronics2001，31，7： | 1 |
| 3 | How the strength properties ofgravel soils depend on the type and state of the sand filling the pores 显示文摘 | Vasil’eva A A Mikheev V V Lobanova G L | 1971 | Soil Mechanics and Foundation Engineering1971，8，3： | 1 |
| 4 | Heat-transfer regularities of the anemometrie wire显示文摘 | MIKHEEV N I SAKHOVSKY A V KHAIRNASOV K R | 2010 | Thermophysics and Aeromeehanies2010，17，2： | 1 |
| 5 | Phytoremediation of radiocesium-contaminated siol in the vicinity of chernobyl,Ukraine显示文摘 | Dushenkovs Mikheev A Prokjnevsky A el al | 1999 | Environ Sci Technol1999，33，3： | 1 |
| 6 | Phylogenetic analysis of chemokine-binding protein gene from orthopoxviruses显示文摘 | Mikheev MV Feshchenko MV Shchelkunov SN | 2004 | Mol Gen Mikrobiol Virusol2004，，1： | 1 |
| 7 | Catalytic phenylation of hydrogen-containing alkylchlorosilanes with benzene显示文摘 | Malnova G N Mikheev E P Klebansky A L | 1957 | Doklady Akademii Nauk SSSR1957，117，： | 1 |
| 8 | Identification of orthopoxvirus species using oligonucleotide microchips显示文摘 | Mikheev M V Lapa S A Shchelkunov S N | 2003 | Vopr Virusol2003，48，1： | 1 |
| 9 | A single-mirror electromechanical laser scanning system显示文摘 | MIKHEEV G M KALYUZHNY D G MOGILEVA T N | 2003 | Instruments and Experimental Techniques2003，46，5： | 1 |
| 10 | Mechanically activated synthesis of monosilane by the reaction of calcium hydride with silicon tetrafluo- ride显示文摘 | TROSHIN O Y BULANOV A D MIKHEEV V S | 2010 | Russian Journal of Applied Chemistry2010，83，6： | 1 |
| 11 | Phy-toremediation of radiocesium contaminated soil in the Vic-inity of Chernobyl, Ukraine 显示文摘 | Dushenkov S Mikheev A Prokhenvsky A | 1999 | Environmental ScienceTechnology1999，33，： | 1 |
| 12 | Age and growth of the squid Sthenoteuthis pteropus ( Oegopsida : Ommastrephidae ) from the central-east Atlantic 显示文摘 | ARKHIPKIN A MIKHEEV A | 1992 | Journal of Experimental Marine Biology and Ecology1992，163，2： | 1 |
| 13 | Amplification of ultrashort laser pulses in the photolytically driven XeF (C→A) active medium 显示文摘 | TCHEREMISKINE V I SENTIS M L MIKHEEV L D | 2002 | A P L2002，81，3： | 1 |
| 14 | Phytore- mediation of Radiocesitml Contaminated Soil in the Vicinity of Chernobyl Ukraine 显示文摘 | Dushenkov S Mikheev A Prokhnevskya | 1999 | Environmental Science and Technology1999，33，3： | 1 |
| 15 | Reactivity of Cyclocarbonate Groups in Modified Epoxy-amine Compositions显示文摘 | Garipov Sysoev Mikheev | 2003 | Doklady Physical Chemistry2003，393，1： | 1 |
| 16 | A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation 显示文摘 | Mikheev AM Mikheeva SA Liu B | 2004 | Carcino- genesis2004，25，1： | 1 |
| 17 | Reactivity of eyclocarbonate groups in modified epoxy-amine compositions显示文摘 | GARIPOV R M SYSOEV V A MIKHEEV V V | 2003 | Doklady Physical Chemistry2003，393，1： | 1 |
| 18 | Dickkopf-1 activates cell death in MDA-MB435 melanoma cells 显示文摘 | Mikheev AM Mikheeva SA Rostomily R | 2007 | Biochem Biophys Res Commun2007，352，3： | 1 |
| 19 | TWIST1 promotes invasion through mesenchymal change in human glioblastoma 显示文摘 | Mikheeva SA Mikheev AM Petit A | 2010 | Mol Cancer2010，9，： | 1 |
| 20 | Dickkopf-1 ac tivates cell death in MDA-MB435 melanoma cells显示文摘 | Mikheev A M Mikheeva S A Rostomily R | 2007 | Biochem Biophys Res Commun2007，352，3： | 1 |
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