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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | 表观难治性高血压患者的交感神经活性和动脉压力反射功能显示文摘与非难治性高血压相比,真性难治性高血压(resistant hypertension,RHT)的特征是肾上腺素能神经的显著激活和反射改变。然而该特征是否是RHT特有的还是和表观RHT(apparent RHT,ARHT)共有的,仍不清楚。 | 陈嘉睿 练桂丽 Dell’Oro R Quarti-Trevano F Seravalle G Zanchettin F Bertoli S Airoldi F Mancia G Grassi G | 2019 | 中华高血压杂志2019，27，10： | 2 |
| 3 | Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives显示文摘 | Grassi G Dell'Oro R Facchini A | 2004 | J Hypertens2004，22，12： | 1 |
| 4 | Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives显示文摘 | Grassi G Dell'Oro R Facchini A | 2004 | J Hypertens2004，22，12： | 1 |
| 5 | Surfaetant protein(SP) B associa- tions and interactions with SP-A in white and black subjects with re- spiratory distress syndrome 显示文摘 | ~oros J Fan R Diangelo S | 2001 | Pediatr Int2001，43，6： | 1 |
| 6 | Levels and distribution of polybrominated diphenyl ethers in water, surface sediments, and bivalves from the San Francisco estuary 显示文摘 | Oros D R Hoover D Rodigari F | 2005 | Environmental Science and Technology2005，39，1： | 1 |
| 7 | Biomass Burning as the Main Source of Organic Aerosol Particulate Matter in Malaysia during Haze Episodes显示文摘 | Radzibin Abas M Oros D R Simoneit B R T | 2004 | Chemosphere2004，55，8： | 1 |
| 8 | Levels and distribution of polybrominated diphenyl ethers in water, surface sediments, and bivalves from the San Francisco Estuary 显示文摘 | OROS D R HOOVER D RODIGARI F | 2005 | Environmental Science & Technology2005，39，： | 1 |
| 9 | Levels and distribution of polybrominated diphenyl ethers in water, surface sediments, and bivalves from the San Francisco estuary 显示文摘 | Oros D R Hoover D Rodigari F | 2005 | Environmental Science & Technology2005，39，1： | 1 |
| 10 | Levels and distribution of polybrominated diphenyl ethers in water, surface sediment, and bivalves from the San Francisco Estuary显示文摘 | Oros D R Hoover D Rodigari F | 2005 | Environ Sci Technol2005，39，1： | 1 |
| 11 | Neurobehavior in term,small-for-gestational age infants with normal placental function显示文摘 | Figueras F Oros D Cruz-Martinez R | 2009 | Pediatrics2009，124，： | 1 |
| 12 | Polycyclic aromatic hydrocarbon (PAH) contamination in San Francisco Bay: A 10-year retrospective of monitoring in an urbanized estuary显示文摘 | Oros O R Ross J R M Robert B S | 2007 | Environmental Research2007，105，： | 1 |
| 13 | Polycyclic aromatic hydrocarbons in the San Francisco Estuary water column:sources,spatial distributions,and temporal trends(1993-2001)显示文摘 | John R M Ross Daniel R Oros | 2004 | Chemosphere2004，57，8： | 1 |
| 14 | Molecular tracers for smoke from charring/burning of chitin biopolymer显示文摘 | Simoneit B R T Oros D R Elias V O 2000a | 2000 | Chemosphere:Global Change Science2000，2，： | 1 |
| 15 | Angiotensin sympathetic system interactions in cardiovascular and metabolic disease显示文摘 | Maccia G Dell'Oro R Quarti-Trevano F | 2006 | J Hypertens Suppl2006，24，： | 1 |
| 16 | Identification and emission rates of molecular tracers in coal smoke particulate matter显示文摘 | Oros D R Simoneit B R T | 2000 | Fuel2000，79，： | 1 |
| 17 | Structural alterations of the retinal microcirculation in the 'prehyper- tensive' high-normal blood pressure state 显示文摘 | Grassi G Buzzi S Dell' oro R | 2013 | Curr Pharm Des2013，19，13： | 1 |
| 18 | Levels and distribution of polybrominated diphenyl ethers in water, surface sediments, and bivalves from the San Francisco estuary显示文摘 | OROS D R HOOVER D RODIGARI F | 2005 | Environmental Science and Technology2005，39，： | 1 |
| 19 | Short- and long-term neu-roadrenergic effects of moderate dietary sodium restriction in essentialhypertension显示文摘 | Grassi G Dell*Oro R Seravalle G | 2002 | Circulation2002，106，15： | 1 |
| 20 | Identification and emission rates of molecular tracers in coal smoke particulate matter显示文摘 | Oros D Simoneit B R T | 2000 | Fuel2000，79，5： | 1 |
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