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11篇 您的检索式：作者名="Micuda"

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		题名	作者	年代	出处	被引量
	1	Telomere attrition oc- curs during ex vivo expansion of human dental pulp stem cells显示文摘	Mokry J Soukup T Micuda S	2010	J Biomed Biotechnol2010，2010，67：	1
	2	Predictive biomarkers in breast cancer: their value in neoadjuvant chemotherapy 显示文摘	Fuksa L Micuda S Grim J	2012	Cancer In- vest2012，30，9：	1
	3	Influence of amiodarone on urinary excretion of 6β-hydroxycortisol in humans显示文摘	MICUDA S HODAC M SISPERA L	2001	Physiol Res2001，50，2：	1
	4	Expression and func- tion of P-glycoprotein in normal tissues: effect on pharma- cokinetics 显示文摘	Staud F Ceckova M Micuda S	2010	Methods Mol Biol2010，596，：	1
	5	Predictive biomarkers inbreast cancer : their value in neoadjuvant chemotherapy 显示文摘	Fuksa L Micuda S Grim J	2012	Cancer Invest2012，30，9：	1
	6	Telomere attrition occurs during ex vivo expansion of human dental pulp stem cells 显示文摘	MOKRY J SOUKUP T MICUDA S	2010	J Biomed Biotechnol2010，，：	1
	7	Predictive biomarkers in breastcancer: their value in neoadjuvant chemotherapy 显示文摘	Fuksa L’Micuda S Grim J	2012	Cancer In-vest2012，30，9：	1
	8	Inhibitory effects of memantine on human cytochrome P450 activities : prediction of in vivo drug interactions 显示文摘	MICUDA S MUNDLOVA L ANZENBACHEROVA E	2004	Eur J Clin Pharmacol2004，60，8：	1
	9	Low Expression of NQO1 Predicts Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Patients Treated with TAC Regimen显示文摘	Grim J Jandík P Slánská I Dolezelová-Brcáková E Fuksa L Ryska A Knízek J Petera J Micuda S Hornychova H	2012	Folia Biologica2012，，5：	1
	10	Telomere attrition occurs during ex vivo expansion of human dental pulp stem cells显示文摘	Mokry J Soukup T Micuda S	2010	J Biomed Biotechnol2010，，：	1
	11	Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats显示文摘AIM To investigate the effect of resveratrol on biliary secretion of cholephilic compounds in healthy and bile duct-obstructed rats. METHODS Resveratrol(RSV) or saline were administered to rats by daily oral gavage for 28 d after sham operation or reversible bile duct obstruction(BDO). Bile was collected 24 h after the last gavage during an intravenous bolus dose of the Mdr1/Mrp2 substrate azithromycin. Bile acids,glutathione and azithromycin were measured in bile to quantify their level of biliary secretion. Liver expression of enzymes and transporters relevant for bile production and biliary secretion of major bile constituents and drugs were analyzed at the m RNA and protein levels using q RT-PCR and Western blot analysis,respectively. The TR-FRET PXR Competitive Binding Assay kit was used to determine the agonism of RSV at the pregnane X receptor. RESULTS RSV increased bile flow in sham-operated rats due to increased biliary secretion of bile acids(BA) and glutathione. This effect was accompanied by the induction of the hepatic rate-limiting transporters for bile acids and glutathione,Bsep and Mrp2,respectively. RSV also induced Cyp7 a1,an enzyme that is crucial for bile acid synthesis; Mrp4,a transporter important for BA secretion from hepatocytes to blood; and Mdr1,the major apical transporter for xenobiotics. The findings were supported by increased biliary secretion of azithromycin. The TR-FRET PXR competitive binding assay confirmed RSV as a weak agonist of the human nuclear receptor PXR,which is a transcriptional regulator of Mdr1/Mrp2. RSV demonstrated significant hepatoprotective properties against BDO-induced cirrhosis. RSV also reduced bile flow in BDO rats without any corresponding change in the levels of the transporters and enzymes involved in RSV-mediated hepatoprotection. CONCLUSION Resveratrol administration for 28 d has a distinct effect on bile flow and biliary secretion of cholephilic compounds in healthy and bile duct-obstructed rats.	Eva Dolezelova Alena Prasnicka Jolana Cermanova Alejandro Carazo Lucie Hyrsova Milos Hroch Jaroslav Mokry Michaela Adamcova Alena Mrkvicova Petr Pavek Stanislav Micuda	2017	World Journal of Gastroenterology2017，23，43：	0

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