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| 1 | Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis显示文摘BACKGROUND The proton pump inhibitors(PPIs),used to reduce gastric acid secretion,represent one of the most widely used pharmaceutical classes in the world.Their consumption as a risk factor for the evolution of severe forms of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been investigated as well as the mortality of these patients.These risks also appear to be linked to the duration and the dosage.On the other hand,several studies have emerged with regard to the protective or therapeutic effects of these drugs.More and more evidence underlines the immunomodulatory and anti-fibrotic role of PPIs.In addition,their ability to alkalize the contents of endosomes and lysosomes serves as an obstacle to the entry of the virus into the host cells.AIM To identify studies on the relationship between the intake of PPIs and coronavirus disease 2019(COVID-19)in patients affected by SARS-CoV-2 infection,with the main objective of evaluating the outcomes related to severity and mortality.METHODS A literature review was performed in November 2020.The MEDLINE/PubMed,Cochrane Library,EMBASE and Google Scholar databases were searched for all relevant articles published in English on this topic.The search terms were identified by means of controlled vocabularies,such as the National Library of Medicine’s MESH(Medical Subject Headings)and keywords.The MESH terms and keywords used were as follows:“COVID-19”,“proton pump inhibitors”,“PPIs”,“SARS-CoV-2”,“outcomes”,“severity”and“mortality”.The inclusion criteria regarding the studies considered in our analysis were:meta-analysis,casecontrol,hospital-based case-control,population-based case-control,retrospective studies,online survey,as well as cohort-studies,while articles not published as full reports,such as conference abstracts,case reports and editorials were excluded.We tried to summarize and pool all the data if available.RESULTS A total of 9 studies were found that described the use of PPIs,of which only 5 clearly reported the severity and mortality data in SARS-CoV-2 patients.Our pooled incidence analysis of severe events did not differ between patients with and without PPIs(odds ratio 1.65,95%confidence interval:0.62-4.35)(P=0.314),or for mortality(odds ratio 1.77,95%confidence interval:0.62-5.03)(P=0.286).CONCLUSION Detailed and larger case studies are needed to accurately understand the role of PPIs in this viral infection. | Maddalena Zippi Sirio Fiorino Roberta Budriesi Matteo Micucci Ivan Corazza Roberta Pica Dario de Biase Claudio Giuseppe Gallo Wandong Hong | 2021 | World Journal of Clinical Cases2021，9，12： | 2 |
| 2 | Analysis of energy saving using natural ventilation in a traditional Italian building 显示文摘 | CARDINALE N MICUCCI M RUGGIERO F | 2003 | Energy and Buildings2003，35，2： | 1 |
| 3 | Comparison of compaction induced by conventional and zero tillage in two soils of the Rolling Pampa of Argentina显示文摘 | M.A Taboada F.G Micucci D.J Cosentino R.S Lavado | 1998 | Soil & Tillage Research1998，，1： | 1 |
| 4 | Analysis of energy saving using natural ventilation in a traditional Italian builing显示文摘 | Cardinal N Micucci M Ruggiero F | 2005 | Energy and Buildings2005，35，： | 1 |
| 5 | Family Succession and Firm Performance :Evidence from Italian Family Firms显示文摘 | Cueculelli M Micucci G | 2008 | Journal of Cor- porate Finance2008，，14： | 1 |
| 6 | Pediatric supracon- dylar humerus fractures显示文摘 | BARATZ M MICUCCI C SANGIMINO M | 2006 | Hand Clin2006，22，1： | 1 |
| 7 | Comparison of compaction induced by conventional and zerotillage in two soils of the RollingPampa of Argentina显示文摘 | Taboada M A Micucci F G Cosentino D J | 1998 | Soil and Tillage Research1998，49，： | 1 |
| 8 | Is ethanol - induced bron- chospasm an inflammation - drivent显示文摘 | Antonicwlli L Micucci C Bonifazi F | 2006 | Allergy2006，61，2： | 1 |
| 9 | Is operative laparoscopy safe in ovarian endometriosis 显示文摘 | Prospero D Micucci F | 2009 | Reprod Biomed Online2009，18，2： | 1 |
| 10 | The producer service sector in Italy:Long-term growth and its local determinants 显示文摘 | VALTER DI GIACINTO GIACINTO MICUCCI | 2009 | Spatial Economic Analysis2009，，4： | 1 |
| 11 | Relationship between ARIA classification and drug treatment in allergic rhinitis and asthma显示文摘 | Antonicelli L Micucci C Voltolini S | 2007 | Allergy2007，62，9： | 1 |
| 12 | Allergic rhinitis and asthma comorbidity:ARIA classification of rhinitis does not correlate with the prevalence of asthma显示文摘 | Antonicelli L Micucci C Voltlini S | 2007 | Clin Exp Allergy2007，37，6： | 1 |
| 13 | A novel case of an adenomyosis-related uterine rupture in pregnancy 显示文摘 | Indraccolo U Iannicco A Micucci G | 2015 | Clin Exp Obstet Gyneco12015，42，6： | 1 |
| 14 | Is ethanol-induced bronchospasm an inflammation-driven event?显示文摘 | Antonicelli L Micucci C Bonifazi F | 2006 | Allergy2006，61，2： | 1 |
| 15 | Analysis of energy saving using natural ventilation in a traditional Italian building显示文摘 | Cardinale N Micucci M Ruggiero F | 2003 | Energy and Buildings2003，35，2： | 1 |
| 16 | Development of a process for the preparation of human serum albumin using chromatio graphic methods显示文摘 | Yap HB Young IF Micucci V | 1993 | Biotechnol of Blood Proteins1993，227，： | 1 |
| 17 | Analysis of energy saving using natural ventilation in a traditional italian building 显示文摘 | CARDINAL N MICUCCI M RUGGIERO F | 2005 | Energy and Buildings2005，35，： | 1 |
| 18 | Development of a process for the preparation of human serum albumin using chromatographic methods显示文摘 | Yap HB Young IF Micucci V | 1993 | Biotechnology of Bood Proteins1993，227，： | 1 |
| 19 | Comparison of compaction induced by conventional and zerotillage in two soils of the Rolling Pampa of Argentina 显示文摘 | Taboada M A Micucci F G Cosentino D J | 1998 | Soil and Tillage Research1998，49，： | 1 |
| 20 | Is operative laparoscopy safe in ovarian endometriosis显示文摘 | Prospero D Micucci F | | 0，，02： | 1 |
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