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| 1 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 2 | Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells显示文摘各种各样的干细胞类型在对待光敏电阻器为他们的潜在的申请被测试了退化疾病,例如视网膜炎 pigmentosa (RP ) 和年龄相关的有斑点的退化(AMD ) 。仅仅胚胎的干细胞(转换字符) 到目前为止被显示了产生恢复光敏电阻器缺乏的老鼠的轻反应的功能的光敏电阻器房间,但是仍然有肿瘤形成的一些担心。在这研究,我们有成功地有教养的 Nestin + Sox2 + Pax6 + multipotent 从成年老鼠视网膜的网膜的干细胞(RSC ) ,它能够生产恢复跟随移植的光敏电阻器缺乏的 rd1 异种老鼠的轻反应的功能的光敏电阻器房间。在他们面对 FGF 和 EGF 为超过 35 个段落被扩展了以后,有教养的 RSC 仍然维持稳定的增长和区别潜力。在合适的区别条件下面,他们能区分进在成年视网膜发现的所有主要网膜的房间类型。更重要地,他们能高效地在优化区别条件下面区分进光敏电阻器房间。直到慢慢地堕落的 rd7 异种的 subretinal 空间的后面的移植看,导出 RSC 的光敏电阻器房间与居民一起集成到视网膜,词法上类似于的内长的光敏电阻器和形成的 synapases 网膜的神经原。当移植了进光敏电阻器缺乏的 rd1 异种老鼠的眼睛时,一个 RP 模型,导出 RSC 的光敏电阻器能部分恢复轻反应,显示那些导出 RSC 的光敏电阻器是功能的。最后,为在移植光敏电阻器的眼睛的肿瘤形成没有证据。因此,这研究证明了从成年视网膜孤立的 RSC 有生产能潜在地恢复光敏电阻器房间的损失在 RP 和 AMD 引起的失去的视觉的功能的光敏电阻器房间的潜力。 | Tianqing Li Michelle Lewallen Shuyi Chen Wei Yu Nian Zhang Ting Xie | 2013 | Cell Research2013，23，6： | 7 |
| 3 | News Keyword Extraction Algorithm Based on Semantic Clustering and Word Graph Model显示文摘The internet is an abundant source of news every day. Thus, efficient algorithms to extract keywords from the text are important to obtain information quickly. However, the precision and recall of mature keyword extraction algorithms need improvement. TextRank, which is derived from the PageRank algorithm, uses word graphs to spread the weight of words. The keyword weight propagation in Text Rank focuses only on word frequency. To improve the performance of the algorithm, we propose Semantic Clustering TextRank(SCTR), a semantic clustering news keyword extraction algorithm based on TextRank. Firstly, the word vectors generated by the Bidirectional Encoder Representation from Transformers(BERT) model are used to perform k-means clustering to represent semantic clustering. Then, the clustering results are used to construct a TextRank weight transfer probability matrix. Finally,iterative calculation of word graphs and extraction of keywords are performed. The test target of this experiment is a Chinese news library. The results of the experiment conducted on this text set show that the SCTR algorithm has greater precision, recall, and F1 value than the traditional TextRank and Term Frequency-Inverse Document Frequency(TF-IDF) algorithms. | Ao Xiong Derong Liu Hongkang Tian Zhengyuan Liu Peng Yu Michel Kadoch | 2021 | Tsinghua Science and Technology2021，26，6： | 7 |
| 4 | Magnetron co-sputtering synthesis and nanoindentation studies of nanocrystalline(TiZrHf)_(x)(NbTa)_(1–x)high-entropy alloy thin films显示文摘Refractory high-entropy alloys(HEAs)possess many useful properties such as high strength and high-temperature stability.So far,most studies on refractory HEAs have been limited to a few well-known compositions and on their coarse-grain bulk forms.Here we fabricate nanocrystalline(TiZrHf)_(x)(NbTa)_(1−x)HEA thin films with a large range of compositions(x=0.07–0.90)by the direct current(DC)magnetron co-sputtering technique and measure their mechanical properties using the nanoindentation method.All the as-deposited HEA thin films show a solid-solution body-centered cubic(bcc)structure.As the compositional ratio(x)increases,the elastic modulus decreases from 153 to 123 GPa,following the trend of the rule of mixture.As x increases,the hardness first decreases from 6.5 GPa(x=0.07)to the lowest value(4.6 GPa,x=0.48)and then increases to the highest value(7.1 GPa,x=0.90),showing a concave trend.The change in hardness might be attributed to the combinational influence caused by the atomic size and modulus effects,as well as the texture effect.The authors also propose a few open questions for future studies on this and related HEA systems. | Changjun Cheng Xiaofu Zhang Michel J.R.Haché Yu Zou | 2022 | Nano Research2022，15，6： | 3 |
| 5 | The Spatial and Temporal Variability of Tropospheric NO_(2) during 2005–14 over China Observed by the OMI显示文摘As improved and accumulated satellite records become available,it is significant to provide up-to-date perspectives on the spatiotemporal signatures of tropospheric nitrogen dioxide(NO2)over China,the knowledge of which is helpful for air pollution control.In this study,the Ozone Monitoring Instrument NO2 dataset for the last 10 years(2005–14)was retrieved to examine multiple aspects of NO2 columns,including distributions,trends,and seasonal cycle.The pattern of average NO2suggests five hotspots with column density higher than 20×1015 molec cm-2:Jing-Jin-Tang;combined southern Hebei and northern Henan;Jinan;the Yangtze River Delta;and the Pearl River Delta.Furthermore,substantial and widespread NO2 growths are distributed over the North China Plain.By contrast,downward trends in NO2 amounts prevail in the megacities of Beijing,Shanghai,and Guangzhou,despite generally high loading levels.Except for the Pearl River Delta,there appears to be temporally consistent behaviors across all regions considered,where NO2 had an abrupt decline during 2008 to 2009,then a drastic increase up to 2013,before beginning to reduce again after 2013.However,the NO2 over the Pearl River Delta is not coevolving with the rest,having experienced a moderate rise from 2005 to 2007,followed by a reduction thereafter.A marked seasonality is apparent,with a maximum in winter and a minimum in summer,regardless of the region.The annual amplitude of NO2 is less pronounced over the Pearl River Delta,whereas the largest range is observed over the combined Southern Hebei and Northern Henan region,induced by enhanced NO2emission in wintertime due to intense domestic heating. | WANG Ting WANG Pu-Cai Francois HENDRICK YU Huan Michel VAN ROOZENDAEL | 2015 | Atmospheric and Oceanic Science Letters2015，8，6： | 2 |
| 6 | AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice显示文摘 | Yu Li Shanqin Xu Maria M. Mihaylova Bin Zheng Xiuyun Hou Bingbing Jiang Ogyi Park Zhijun Luo Etienne Lefai John Y.-J. Shyy Bin Gao Michel Wierzbicki Tony J. Verbeuren Reuben J. Shaw Richard A. Cohen Mengwei Zang | 2011 | Cell Metabolism2011，，4： | 2 |
| 7 | Mesenchymal stromal cells may enhance metastasis of neuroblastoma via SDF-1/CXCR4 and SDF-1/CXCR7 signaling显示文摘 | Ming Ma Jie Yu Ye Ruixia Deng Cathleen Michelle Dee Godfrey Chi-Fung Chan | 2011 | Cancer Letters2011，，1： | 2 |
| 8 | Cohort-based long-term ozone exposure-associated mortality risks with adjusted metrics:A systematic review and meta-analysis显示文摘Long-term ozone(O_(3))exposure may lead to non-communicable diseases and increase mortality risk.However,cohort-based studies are relatively rare,and inconsistent exposure metrics impair the credibility of epidemiological evidence synthetization.To provide more accurate meta-estimations,this study updates existing systematic reviews by including recent studies and summarizing the quantitative associations between O_(3) exposure and cause-specific mortality risks,based on unified exposure metrics.Cross-metric conversion factors were estimated linearly by decadal observations during 1990-2019. | Haitong Zhe Sun Pei Yu Changxin Lan Michelle WLWan Sebastian Hickman Jayaprakash Murulitharan Huizhong Shen Le Yuan Yuming Guo Alexander T.Archibald | 2022 | The Innovation2022，3，3： | 2 |
| 9 | Structural analysis of rubble-pile asteroids applied to collisional evolution显示文摘Solar system small bodies come in a wide variety of shapes and sizes,which are achieved following very individual evolutional paths through billions of years.Nevertheless,some common mechanisms can still be found during these processes,e.g.,rubble-pile asteroids tend towards fluid equilibrium as they are reshaped by external disturbances.This paper focuses on the reshaping process of rubble-pile asteroids driven by meteorite impacts.A mesoscale cluster of solid spheres is employed as the principal model for a rubble-pile asteroid,for which little is actually known about their interior structure.We take this simple model as a rough guide to the qualitative aspects of the reshaping processes,and it can reveal,to some degree,the inner workings of rubble-pile asteroids.In our study,numerous possible equilibrium configurations are obtained via Monte Carlo simulation,and the structural stability of these configurations is determined via eigen analysis of the geometric constructions.The eigen decomposition reveals a connection between the cluster’s reactions and the types of external disturbance.Numerical simulations are performed to verify the analytical results.The gravitational N-body code pkdgrav is used to mimic the responses of the cluster under intermittent non-dispersive impacts.We statistically confirm that the stability index I S,the total gravitational potential P G,and the volume of inertia ellipsoid V E show consistent tendency of variation.A common regime is found in which the clusters tend towards crystallization under intermittent impacts,i.e.,only the configurations with high structural stability survive under the external disturbances.The results suggest the trivial non-disruptive impacts might play an important role in the rearrangement of the constituent blocks,which may strengthen these rubble piles and help to build a robust structure under impacts of similar magnitude.The final part of this study consists of systematic simulations over two parameters,the projectile momentum and the rotational speed of the cluster.The results show a critical value exists for the projectile momentum,as predicted by theory,below which all clusters become responseless to external disturbances;and the rotation proves to be significant for it exhibits an“enhancing”effect on loose-packed clusters,which coincides with the observation that several fast-spinning asteroids have low bulk densities. | Yang Yu Derek CRichardson Patrick Michel | 2017 | Astrodynamics2017，1，1： | 2 |
| 10 | Locally transplanted enteric glia improve functional and structural recovery in a rat model of spinal cord injury显示文摘<正>BACKGROUND:We have previously reported that adult enteric glia(EG) facilitate the growth of transected dorsal root axons into the uninjured spinal cord to form functional connections with their targets. OBJECTIVE:The present study investigated the effects of EG on spinal cord function,tissue injury, and axonal regeneration following transplantation into injured rat spinal cords,according to histological and functional outcomes. DESIGN,TIME AND SETTING:A randomized controlled animal experiment was performed at McMaster University,Canada from January 2006 to March 2008. MATERIALS:EG were isolated from rat intestine. METHODS:One week following spinal cord crush,female Wistar rats were injected with an EG suspension(2μL,1×10~5/μL,n=10) or with the same volume of fresh culture medium alone(control animals,n=11).The third group did not receive any injection following laminectomy and served as the sham-operated controls(n=5). MAIN OUTCOME MEASURES:Behavior was tested prior to transplantation and weekly following transplantation,with nine behavioral examinations in total.Open field,hind limb placement response, foot orientation response,and inclined plane test were utilized.Immediately following the final behavioral examination,spinal cord T_9 to L_1 segments were harvested for immunohistochemical and hematoxylin-eosin staining to determine astroglial scarring,axonal regeneration and spinal cord lesion size. RESULTS:Rats with EG transplantation exhibited significantly better locomotor function with reduced tissue damage,compared with the control rats.Cystic cavities were present 2 months after injury in spinal cords from both control groups.In contrast,rats injected with EG did not present with cystic lesions.In addition,the injury site consisted of cellular material and nerve fibers,and axonal regeneration was apparent,with dense labeling of neurofilament-positive axons within the injury site. Moreover,regenerating axons were intimately associated with transplanted EG CONCLUSION:These data indicated that EG enhanced functional improvement,which was associated with reduced tissue damage and axonal regeneration following transplantation into injured spinal cords. | Shucui Jiang Mohammad I. Khan James R. Bain Cai Jiang Christopher R. Hansebout Zesheng Yu Yuqing Liu Michel P, Rathbone | 2009 | Neural Regeneration Research2009，4，9： | 2 |
| 11 | Inter-individual differences in the responses to aerobic exercise in Alzheimer’s disease: Findings from the FIT-AD trial显示文摘Background:Despite the strong evidence of aerobic exercise as a disease-modifying treatment for Alzheimer’s disease(AD)in animal models,its effects on cognition are inconsistent in human studies.A major contributor to these findings is inter-individual differences in the responses to aerobic exercise,which was well documented in the general population but not in those with AD.The purpose of this study was to examine inter-individual differences in aerobic fitness and cognitive responses to a 6-month aerobic exercise intervention in community-dwelling older adults with mild-to-moderate dementia due to AD.Methods:This study was a secondary analysis of the Effects of Aerobic Exercise for Treating Alzheimer’s Disease(FIT-AD)trial data.Aerobic fitness was measured by the shuttle walk test(SWT),the 6-min walk test(6MWT),and the maximal oxygen consumption(VO2max)test,and cognition by the AD Assessment Scale-Cognition(ADAS-Cog).Inter-individual differences were calculated as the differences in the standard deviation of 6-month change(SDR)in the SWT,6MWT,VO2max,and ADAS-Cog between the intervention and control groups.Results:Seventy-eight participants were included in this study(77.4±6.3 years old,mean±SD;15.7±2.8 years of education;41%were female).VO2max was available for 26 participants(77.7±7.1 years old;14.8±2.6 years of education;35%were female).The SDR was 37.0,121.1,1.7,and 2.3 for SWT,6MWT,VO2max,and ADAS-Cog,respectively.Conclusion:There are true inter-individual differences in aerobic fitness and cognitive responses to aerobic exercise in older adults with mild-tomoderate dementia due to AD.These inter-individual differences likely underline the inconsistent cognitive benefits in human studies. | Fang Yu Dereck Salisbury Michelle A.Mathiason | 2021 | Journal of Sport and Health Science2021，10，1： | 1 |
| 12 | Fibrin-binding, peptide amphiphile micelles for targeting glioblastoma显示文摘 | Eun Ji Chung Yu Cheng Ramin Morshed Kathryn Nord Yu Han Michelle L. Wegscheid Brenda Auffinger Derek A. Wainwright Maciej S. Lesniak Matthew V. Tirrell | 2014 | Biomaterials2014，，4： | 1 |
| 13 | Site-specific gene insertion mediated by a Cre-loxP-carrying lentiviral vector 显示文摘 | Michel G Yu Y Chang T | 2010 | Mol Ther2010，18，18： | 1 |
| 14 | Dynamic load balancing on web-server systems显示文摘 | Valeria Cardellini Michele Colajanni Philip S Yu | 1999 | IEEE Intemet Computing1999，3，3： | 1 |
| 15 | Crustal motion and block behaviour in SE-Asia from GPS measurements 显示文摘 | MICHEL G W YU Y Q ZHU S Y | 2001 | Earth and Planetary Science Letters2001，187，： | 1 |
| 16 | Dynamic load balancing on Web-server systems显示文摘 | Valeria Cardellini Michele Colajanni Phili PS Yu | 1999 | IEEE Internet Computing1999，3，3： | 1 |
| 17 | Changes in P2X receptor responses of sensory neurons from P2X3-deficient mice显示文摘 | Philip M Yu Z Michelle B | 2001 | Eur J Neurosci2001，14，： | 1 |
| 18 | Dynamicload balancing on Web-Server system显示文摘 | Valeria Cardellini Michele Cohjanni Philip S Yu | 1999 | IEEE Interact Computing1999，3，3： | 1 |
| 19 | Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population‐based study in China显示文摘 | GabriellaAndreotti JinboChen Yu‐TangGao AsifRashid Shih‐ChenChang Ming‐ChangShen Bing‐ShengWang Tian‐QuanHan Bai‐HeZhang Kim N.Danforth Michelle D.Althuis Ann W.Hsing | 2008 | Int J Cancer2008，，10： | 1 |
| 20 | Site-specific gene inser- tion mediated by a Cre-loxP-carrying lentiviral vector显示文摘 | Michel G Yu Y Chang T | 2010 | Mol Ther2010，18，10： | 1 |
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