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| 1 | THE EFFECTS OF RADIX SALVIAE MILTIORRHIZAE ON LIPID ACCUMULATION OF PEROXIDIZED LOW DENSITY LIPOPROTEIN IN MOUSE PERITONEAL MACROPHAGES ?LIPID ANALYSIS AND MORPHOLOGICAL STUDIES显示文摘Mouse peritoneal macrophages were incubated in DMEM with pox-LDL and Rradlx Salviae Miltiorrhizae (RSM) to investigate the effects of RSM on the internalization of peroxidized low density lipoprotein (pox-LDL) by using lipid analysis and electron microscopy. Lipid peroxide (LPO) concentrations were increased slightly in the medium after incubation of macrophages with normal LDL (n-LDL), while decreased significantly in the media after incubation of macrophages with pox-LDL. In the three groups with pox-LDL, it could be found that there was a dose-dependent decrease of concentrations of LPO and total cholesterol (TCH) in the two RSM groups, and the decrease in the two RSM groups was much greater than in the group without RSM. RSM accelerated a more decrease of LPO than cholesterol contents in the media containing pox-LDL. The ultrastructural studies also showed that RSM induced the accumulation of lipid droplets in the cytoplasm of mouse peritoneal macrophages. The results suggested that RSM could accelerate the phagocytosis and degradation of pox-LDL by macrophages. | 于生元 匡培根 Takemichi Kanazawa Kogo Onodera Hirohumi Metoki Yasaburo Oike | 1998 | Journal of Traditional Chinese Medicine1998，18，4： | 2 |
| 2 | 初产妇和经产妇妊娠期间的诊室和家庭血压显示文摘妊娠高血压可导致分娩时产生严重的并发症,如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法:入选初产妇和经产妇共575名,评估妊娠高血压和先兆子痫的发病率。收集在一家日本产科医院接受产前检查的530名正常血压孕妇的家庭和诊室血压值。诊室血压为产前检查2次测量的血压平均值,参与者妊娠期间每日清晨在家自测血压。 | Ishikuro M Obara T Metoki H Ohkubo T Yamamoto M Akutsu K Sakurai K Iwama N Katagiri M Yagihashi K Yaegashi N Mori S Suzuki M Kuriyama S Imai Y 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，6： | 2 |
| 3 | Prognostic significance of morning surge in blood pressure: which definition, which outcome 显示文摘 | Ohkubo T Metoki H Imai Y | 2008 | Blood Press Monit2008，13，3： | 1 |
| 4 | Diurnal blood pressure variation and car- diovascular prognostic in a community-based study of Ohasama,Japan显示文摘 | Metoki H Ohkubo T Imai Y | 2010 | Hypertens Res2010，3，7： | 1 |
| 5 | Prognostic significance for stroke of a morning presser surge and a nocturnal blood pressure decline显示文摘 | METOKI H OHKUBO T KIKUYA M | | 0，，04： | 1 |
| 6 | Prognostic significance for stroke of a morning pressure and a nocturnal blood pressure decline:The Ohasama study显示文摘 | Metoki H Ohkubo T Kikuya M | 2006 | Hypertension2006，47，： | 1 |
| 7 | Prognosis of 'masked' hypertension and 'white-coat' hypertension detected by 24 h ambulatory blood pressure monitoring:10-year follow-up from the Ohasama study显示文摘 | Kikuya M Metoki H | 2005 | J Am Coll Cardiol2005，46，： | 1 |
| 8 | Effect of nilvadipine on central visual field in retinitis pigmentosa- a 30-month clinical trial 显示文摘 | Nakazawa M Ohguro H Takeuchi K Miyagawa Y Ito T Metoki T | 2011 | Ophthalmologica2011，225，2： | 1 |
| 9 | Prognostic significance for stroke of a morning pressor surge and a nocturnal blood pressure decline : the Ohasama study 显示文摘 | Metoki H Ohkubo T Kikuya M | 2006 | Hypertension2006，47，2： | 1 |
| 10 | Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sexor conventional risk factors for atherosclerosis 显示文摘 | Yamaguchi S Yamada Y Metoki N | 2006 | Int J Mol Med2006，18，5： | 1 |
| 11 | Prognostic significance for stroke of a morning pressor surge and a nocturnal blood pressure decline:the Ohasama study显示文摘 | Metoki H Ohkubo T Kikuya M | 2006 | Hypertension2006，47，2： | 1 |
| 12 | Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia显示文摘 | Ishikawa A Yoshida H Metoki N | 2007 | Neurosci Res2007，59，4： | 1 |
| 13 | Prognosis of 'masked hy-pertension and white-coat* hypertension detected by 24-h ambula-tory blood pressure monitoring 10-year follow-up from the Ohasa-ma study显示文摘 | Ohkubo T Kikuya M? Metoki H | 2005 | J Am Coll Cardiol2005，46，3： | 1 |
| 14 | Prognosis of ' masked' hypertension and 'white-coat' hypertension detected by 24-h ambulatory blood pressure monitoring 10-year follow-up from the Ohasama study 显示文摘 | Ohkubo T Kikuya M Metoki H | 2005 | J Am Coil Cardiol2005，46，3： | 1 |
| 15 | 妊娠期饮酒与妊娠期高血压疾病的关系:日本环境与儿童研究显示文摘该研究在日本环境和儿童研究中调查了母亲孕期饮酒与妊娠期高血压疾病的关系。这是一项全国范围的出生队列研究,共有76940名孕妇被纳入分析。使用两份问卷获得有关怀孕期间饮酒量的信息:T1和T2。T1和T2问卷的平均孕龄分别为(16.5±5.8)和(27.9±3.7)周。饮酒作为暴露,妊娠高血压疾病作为结果,并将可能的混杂因素纳入具有logit连接功能的广义线性混合效应模型中。 | 刘青 叶鹏 Iwama N Metoki H Nishigori H Mizuno S Takahashi F Tanaka K Watanabe Z Saito M Sakurai K Ishikuro M Obara T Tatsuta N Nishijima I Sugiyama T Fujiwara I Kuriyama S Arima T Nakai K Yaegashi N | 2018 | 中华高血压杂志2018，26，11： | 1 |
| 16 | Edaravone inh ibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia 显示文摘 | Ishikawa A Yoshida H Metoki N | 2007 | Neurosci Res2007，59，4： | 1 |
| 17 | Prognosiso 'masked' hypertension and 'white-coat' hypertension detected by 24h ambulatory blood pressure monitoring 10-year follow-up from the Ohasama study显示文摘 | Okhubo T Kikuya M Metoki H | 2005 | J A m Coll Cardio2005，46，3： | 1 |
| 18 | Genetic risk for ischemic and hemorrhagic stroke显示文摘 | Metoki N Yoshida H | 2006 | Arterioscler Thromb Vas Biol2006，26，： | 1 |
| 19 | Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia 显示文摘 | Ishikawa A Yoshida H Metoki N | 2007 | Neurosei Res2007，59，4： | 1 |
| 20 | Elevated plasma brain natriu-retic peptide levels independent of heart disease in acute ischemicstroke:correlation with stroke severity显示文摘 | Tomita H Metoki N Saitoh G | 2008 | Hypertens Res2008，31，9： | 1 |
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