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| 1 | Frontiers in antibiotic alternatives for Clostridioides difficile infection显示文摘Clostridioides difficile(C.difficile)is a gram-positive,anaerobic spore-forming bacterium and a major cause of antibiotic-associated diarrhea.Humans are naturally resistant to C.difficile infection(CDI)owing to the protection provided by healthy gut microbiota.When the gut microbiota is disturbed,C.difficile can colonize,produce toxins,and manifest clinical symptoms,ranging from asymptomatic diarrhea and colitis to death.Despite the steady-if not risingprevalence of CDI,it will certainly become more problematic in a world of antibiotic overuse and the post-antibiotic era.C.difficile is naturally resistant to most of the currently used antibiotics as it uses multiple resistance mechanisms.Therefore,current CDI treatment regimens are extremely limited to only a few antibiotics,which include vancomycin,fidaxomicin,and metronidazole.Therefore,one of the main challenges experienced by the scientific community is the development of alternative approaches to control and treat CDI.In this Frontier article,we collectively summarize recent advances in alternative treatment approaches for CDI.Over the past few years,several studies have reported on natural product-derived compounds,drug repurposing,highthroughput library screening,phage therapy,and fecal microbiota transplantation.We also include an update on vaccine development,pre-and probiotics for CDI,and toxin antidote approaches.These measures tackle CDI at every stage of disease pathology via multiple mechanisms.We also discuss the gaps and concerns in these developments.The next epidemic of CDI is not a matter of if but a matter of when.Therefore,being well-equipped with a collection of alternative therapeutics is necessary and should be prioritized. | Matthew Phanchana Phurt Harnvoravongchai Supapit Wongkuna Tanaporn Phetruen Wichuda Phothichaisri Supakan Panturat Methinee Pipatthana Sitthivut Charoensutthivarakul Surang Chankhamhaengdecha Tavan Janvilisri | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 2 | B(i)ological removal of cyanide compounds from electroplating wastewater (EPWW) by sequencing batch reactor (SBR) system显示文摘 | Suntud Sirianuntapiboon Kanidta Chairattanawan Methinee Rarunroeng | 2008 | Journal of Hazardous Materials2008，154，13： | 1 |
| 3 | Fruit processing residues as an alternative fuel for drying in Northern Thailand显示文摘 | Marcus Nagle Kennedy Habasimbi Busarakorn Mahayothee Methinee Haewsungcharern Serm Janjai Joachim Müller | 2010 | Fuel2010，，2： | 1 |
| 4 | The Effects of Working Experience Practicum to Strengthen Students’Self-determination Behaviors in Practicum Subject of Business and Computer Education Major,Faculty of Education,Kasetsart University显示文摘The research purpose was to study the effects of working experience practicum to strengthen students’self-determination behaviours.Research population were 23 students in 3rd year in Business and Computer in Vocational Education Department,Faculty of Education,Kasetsart University who registered to study in Practicum Subject in 2016 academic year.Three research instruments were conducted,including,(1)Practicum Manual,(2)Interview Form,and(3)Focus Group Discussion Sheet.Research instruments were verified by four experts who were in four academic areas,including(1)humanity,(2)psychology,(3)business,and(4)human resource by using content validity method.Interview session was divided by 10 groups of companies in which students did their work for 10 weeks.Focus group was administered to discuss with 23 students and share about working problems and solutions.Qualitative data were analyzed by content analysis method,including data analysing,ordering and grouping,and data linking of working practicum.The research results were shown that students learned to understand benefits and limitations of self-determination behaviors and awareness in the essentials of self-determination in four aspects,including(1)attention and responsibility in working achievements,(2)working diligent and tolerance,(3)self-determination with learning motivation,and(4)self-development.The guidelines to encourage students’self-determination behaviors suggested that students should apply Buddha’s teaching(four-step secret of successful working achievements)to achieve their work and adjust students’real life behaviors.Furthermore,researcher presented the best practice guidelines to promote students’self-determination behaviors,including(1)students should think positively to spend time on hardworking and tolerance,(2)students should develop their work through PDCA(Plan,Do,Check,Action)techniques to adjust their work to do better,(3)students should be promoted with skills of 21st century that are necessary to raise students’self-development through teaching and learning in and out of classroom. | Methinee Wongwanich Rumpagaporn | 2018 | Management Studies2018，6，4： | 0 |
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