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| 1 | High prevalence of multidrug-resistance in Acinetobacter baumannii and dissemination of carbapenemase-encoding genes bla_(OXA-23-like),bla_(OXA-24-like)and bla_(NDM-1) in Algiers hospitals显示文摘Objective:To assess and characterize antibiotic resistance in Acinetobacter baumannii strains recovered from 5 health-care facilities in Algiers.Methods:Antibiotic susceptibility testing was performed by agar diffusion and agar dilution methods,resistance genes were identified by PCR and sequencing,and molecular typing of isolates was carried out by enterobacterial repetitive intergenic consensus-PCR(ERIC-PCR).Results:Among 125 tested isolates,117(93.6% ) were multidrug-resistant.of which 94(75.2% ) were imipenem resistant.The bla_(ADC)and bla_(OXA-51-like) genes were detected in all isolates,in association with ISAba I sequence in 84% and 8% (imipenem resistant) of isolates,respectively.The bla_(OXA-23-like) and bla_(OXA-24-like)carbapenemase genes were delected in 67.02% and 20.21% of imipenem-resistant isolates,respectively.The bla_(OXA-23-like) gene is linked to ISAba1 or ISAba4 elements.The metallo-β-lactamase NDM-1 gene was found in 10(10.6% ) imipenem-resisianl strains from three hospitals,it is linked to ISAba125 clement in nine strains.Extended spectrum β-lactamases production was not detected.Imipenem and cefotaxime resistance phenolypes could not be transferred to Escherichia coli by conjugation.Outer membrane protein CarO gene was not delected in four imipenem-resisianl isolates.The aac(6')-1b.sul1,sul2,tetA and tetB genes were present in 5.31% .36.17% .77.65% .1.06% and 65.92% of strains,respectively.Class 1 integrons were detected in 23.4% strains.KRIC-PCR typing showed a genetic diversity among bla_(OXA-23-like) and bla_(OXA-24-like) positive strains,while clonality was observed among bla_(NDM-1)positives.Conclusions:This study highlighted the high prevalence of imipenem resistance in Acinetobacter baumannii in Algiers hospitals mediated mainly by bla_(OXA-23-like),bla_(OXA-24-like),and bla_(NDM-1) genes. | Khadidja Khorsi Yamina Messai Moufida Hamidi Houria Ammari Rabah Bakour | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，6： | 20 |
| 2 | Correction of low corneal astigmatism in cataract surgery显示文摘· AIM: To evaluate and compare aspheric toric intraocular lens(IOL) implantation and aspheric monofocal IOL implantation with limbal relaxing incisions(LRI) to manage low corneal astigmatism(1.0-2.0 D) in cataract surgery.· METHODS: A prospective randomized comparative clinical study was performed. There were randomly recruited 102 eyes(102 patients) with cataracts associated with corneal astigmatism and divided into two groups. The first group received toric IOL implantation and the second one monofocal IOL implantation with peripheral corneal relaxing incisions. Outcomes considered were: visual acuity, postoperative residual astigmatism, endothelial cell count, the need for spectacles, and patient satisfaction. To determine the postoperative toric axis, all patients who underwent the toric IOL implantation were further evaluated using an OPD Scan III(Nidek Co, Japan). Follow-up lasted 6mo.· RESULTS: The mean uncorrected distance visual acuity(UCVA) and the best corrected visual acuity(BCVA) demonstrated statistically significant improvement after surgery in both groups. At the end of the follow-up the UCVA was statistically better in the patients with toric IOL implants compared to those patients who underwent implantation of monofocal IOL plus LRI. The mean residual refractive astigmatism was of 0.4 D for the toric IOL group and 1.1 D for the LRI group(P <0.01). No difference was observed in the postoperative endothelial cell count between the two groups.· CONCLUSION: The two surgical procedures demonstrated a significant decrease in refractive astigmatism. Toric IOL implantation was more effective and predictable compared to the limbal relaxing incision. | Pia Leon Marco Rocco Pastore Andrea Zanei Ingrid Umari Meriem Messai Corrado Negro Daniele Tognetto | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 8 |
| 3 | Cationic PLA nan- oparticles for DNA delivery: comparison of three surface polycations for DNA binding, protection and transfection properties 显示文摘 | Munier S Messai I Delair T | 2005 | Colloid Surf B2005，43，： | 1 |
| 4 | Dissemination of ESBL and Qrrr determinants in Enterobacter cloacae in Algeria显示文摘 | Iabadene H Messai Y Ammari H | 2008 | J Antimicrob Chemother2008，62，1： | 1 |
| 5 | Hybrid observer de- sign for switched linear systems using differential Petri net 显示文摘 | HAMDI E MANAMANNI N MESSAI N | 2009 | Non- linear Analysis: Hybrid Systems2009，3，3： | 1 |
| 6 | Design of a robust fault detection based observer for linear switched systems with external disturbances显示文摘 | Belkhiat D E C Messai N Manamanni N | 2011 | Nonlinear Analysis : Hybrid Systems2011，5，2： | 1 |
| 7 | A new computationally efficient CAD system for pulmonary nodule detection in CT imagery显示文摘 | Messay T Hardie R C Rogers S K | | 0，，03： | 1 |
| 8 | Synthesis of 4-aminoantipyrine Schiff bases and their antimicrobial activities显示文摘Various compounds of 4-aminoantipyrine Schiff bases(M1–M12) were synthesized via a condensation reaction of 4-aminoantipyrine with different benzaldehydes through a conventional method of refluxing the mixture for 3–4 h. The synthesized Schiff bases were characterized by using elemental analyses, FT-IR, UV-Vis, Mass, 1 H and 13 C NMR spectroscopy. The antimicrobial activity of the synthesized Schiff bases was investigated against 12 bacterial strains(Mycobacterium smegmatis, Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Staphylococcus epidermidis, Klebsiella pneumonia, Escherichia coli, Enterobacter cloacae, Klebsiella oxytoca, Proteus vulgaris, Enterobacter aerogenes, and Pseudomonas aeruginosa), and antifungal activities were tested against seven fungal strains(Aspergillus flavus, Aspergillus carbonarious, Aspergillus parasiticus, Aspergillus fumigatus, Aspergillus niger, Fusarium verticillioides and Fusarium proliferatum). The antimicrobial activities of the synthesized compounds were compared with standard streptomycin and nalidixic acid. The results obtained from antibacterial assay indicated that M1–M12 inhibited potential growth of Proteus vulgaris with minimum inhibitory concentrations(MICs) ranging from 15.6–250 μg/mL compared with the standard nalidixic acid with an MIC of 500 μg/mL. Moreover, we could conclude that most of the tested compounds experienced mild to low activities at 15.6 μg/mL. Their activities could be attributed to their low concentration s. The antifungal analysis showed that the tested fungi were not sensitive to the prepared Schiff bases at the prepared concentration of 500 μg/mL. Therefore, we recommended further analysis on both cytotoxicity and minimum bactericidal concentration(MBC) to ascertain their potential effects against human cells. | Olatunde S.Oladeji Monisola I.Ikhile Carine M.D.Fotsing Messai Mamo Patrick G.Ndungu Derek T.Ndinteh | 2018 | Journal of Chinese Pharmaceutical Sciences2018，27，11： | 1 |
| 9 | Microenvironmental hypoxia orchestrating the cell stroma cross talk, tumor progression and antitumor response显示文摘 | Noman MZ Messai Y Carre T | 2011 | Crit Rev Immu- nol2011，31，5： | 1 |
| 10 | Hypoxia promotes tumor growth in linking angiogenesis to immune escapte 显示文摘 | Chouaib S Messai Y Couve S | 2012 | Front Imr munol2012，3，： | 1 |
| 11 | Microenvir- onmental hypoxia orchestrating the cell stroma cross talk, tumor progression and anti-tumor response 显示文摘 | Noman MZ Messai Y Carre T | 2011 | Crit Rev Immunol2011，31，5： | 1 |
| 12 | Segmentation of pulmonary nodules in computed tomography using a regression neuralnetwork approach and its application to the lung image database consortium and image database resource initiative dataset显示文摘 | Messay T Hardie R C Tuinstra T R | 2015 | Medical Image Analysis2015，22，1： | 1 |
| 13 | Dissemination of ESBL and Qnr determinants in Enterobacter cloacae in Algeria 显示文摘 | Iabadene H Messai Y Ammari H | 2008 | J Antimicrob Chemother2008，62，1： | 1 |
| 14 | Prevalence and characterization of extended-spectrumβ-1actamases in Klebsiella pneumoniae in Algiers hospitals (Algeria) 显示文摘 | Messai Y Abadene H Benhassine T | 2008 | Pathologie Biologie2008，56，5： | 1 |
| 15 | Incidence and risk fac- tors of vitamin D deficiency in critically ill patients: results from a prospective observational study显示文摘 | Lucidarme O Messai E Mazzoni T etal | 2010 | Intensive Care Med2010，36，9： | 1 |
| 16 | Virulence profiles and antibiotic susceptibility patterns of KlebsieUa pneumoniae strains i- solated from different clinical specimens 显示文摘 | E1 Fertas-Aissani R Messai Y Alouache S | 2012 | Pathol Biol ( Paris )2012，，： | 1 |
| 17 | Cationic PLA nanoparticles for DNA delivery: comparison of three surface polycations for DNA binding, protection and transfection properties 显示文摘 | MUNIER S MESSAI I DELATR T | 2005 | Colloids Surf B Biointerfaces2005，43，34： | 1 |
| 18 | Maximum power point tracking using a GA optimized fuzzy logic controller and its FPGA implementation显示文摘 | Messai A Mellit A Guessoum A | 2011 | Solar Energy2011，85，： | 1 |
| 19 | Integration of quantum cryptography through satellite networks transmission显示文摘 | Skander Aris Abderraouf Messai Male Benslama | 2011 | American Journal of Applied Science2011，8，1： | 1 |
| 20 | A new computationally efficient CAD system for pulmonary nodule detection in CT imagery显示文摘 | Messay T Hardie R C Rogers S K | 2010 | Medical Image Analysis2010，14，： | 1 |
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